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Human physiology --- Physiology --- Cell Physiological Phenomena --- Physiology. --- Cell Physiological Phenomena. --- 612 --- Cell Physiological Phenomenon --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Cells --- Fysiologie --- physiology --- Cell Physiological Process --- Cell Physiological Processes --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Human biology --- Medical sciences --- Human body

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Molecular biology --- Cell physiology --- Electron microscopy --- Cell physiology. --- Electron microscopy. --- Molecular biology. --- Microscopie électronique. --- Microscopie. --- Maladie. --- Aspect moléculaire. --- Microscopy, Electron. --- Electron Microscopy --- Molecular biochemistry --- Molecular biophysics --- Cell function --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Microscopy --- Cytology --- Physiology --- Molecular Biology --- Cell Physiology --- Microscopy, Electron --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiological Processes --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetic Phenomena --- physiology --- Molecular Biology. --- Cell Physiological Phenomena.

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Lipid rafts-discrete regions in cell membranes that are rich in cholesterol and sphingolipids-are emerging not only as pivotal command and control centers for cellular signaling processes, but also as central to a wide array of human diseases, including immune disorders, diabetes, cardiovascular disease, and Alzheimer's disease. In Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine, multidisciplinary experts offer cutting-edge reviews of our current understanding of these membrane microdomains and their physiological and pathological roles. Here, readers will discover how lipid rafts change in cells over time and how they respond to various environmental signals, how cholesterol modulates the signaling function of lipid rafts, and how lipid rafts, the extracellular matrix, and the cell cytoskeleton structurally interact. Also described are the role of lipid rafts in learning, memory, and cancer, and as portals for endocytic uptake of an anticancer- and apoptotic alkyl-lysophospholipid. The authors also present emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and that alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. They also describe techniques for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts. Comprehensive and insightful, Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine offers researchers a multidisciplinary review of the latest basic, translational, and clinical research that promises to transform our understanding microdomain signaling mechanisms.

Membrane Microdomains --- Apoptosis --- Lipids --- Signal Transduction --- Synapses --- Membrane lipids --- Cellular signal transduction --- Lipides membranaires --- Transduction du signal cellulaire --- pathology --- physiology --- metabolism --- Apoptosis. --- Cellular signal transduction. --- Membrane lipids. --- Metabolism --- Physiology --- Lipid Metabolism --- Pathology --- Biochemical Processes --- Nervous System --- Cell Membrane Structures --- Metabolic Phenomena --- Chemicals and Drugs --- Cell Death --- Cell Physiological Processes --- Medicine --- Intercellular Junctions --- Biological Science Disciplines --- Phenomena and Processes --- Natural Science Disciplines --- Biochemical Phenomena --- Cell Membrane --- Cell Physiological Phenomena --- Chemical Processes --- Health Occupations --- Anatomy --- Cellular Structures --- Disciplines and Occupations --- Chemical Phenomena --- Cells --- Cytology --- Animal Biochemistry --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Life sciences. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Membranes (Biology)

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Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.

Neoplasms --- Cell Death --- Gene Therapy --- Receptors, Tumor Necrosis Factor --- Apoptosis --- Cell receptors --- Cancer --- Cellular signal transduction --- Apoptose --- Récepteurs cellulaires --- Transduction du signal cellulaire --- immunology --- therapy --- methods --- Molecular aspects --- Aspect moléculaire --- Kanker --- Kanker ; moleculaire aspecten --- Apoptosis. --- Cancer -- Molecular aspects. --- Cell receptors. --- Cellular signal transduction. --- Biological Therapy --- Genetic Engineering --- Diseases --- Investigative Techniques --- Cell Physiological Processes --- Receptors, Cytokine --- Cell Physiological Phenomena --- Receptors, Immunologic --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Techniques --- Therapeutics --- Receptors, Cell Surface --- Phenomena and Processes --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Methods --- Medicine --- Biology --- Health & Biological Sciences --- Cytology --- Oncology --- Molecular aspects. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Binding sites (Biochemistry) --- Cell membranes --- Cell death

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In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field. It became a memorable event in an illustrious series of International Symposia on Cell Volume and Signaling. This series, started by Professors Vladimir Strbák, Florian Lang and Monte Greer in Smolenice, Slovakia in 1997 and continued by Professors Rolf Kinne, Florian Lang and Frank Wehner in Berlin in 2000, is projected for 2005 in Copenhagen to be hosted by our colleague, Professor Else Hoffmann and her team. We dearly miss Monte Greer to whom this symposium was dedicated and addressed so eloquently by Vladimir Strbák in his Dedication to Monte. Monte and I became friends in Smolenice and had begun to discuss the 2003 meeting only a few days before his tragic accident in 2002. There are others who were not with us, and we missed them, too. We would not have been able to succeed in this event without the unflagging support of our higher administration at Wright State University, the NIDDKD of the National Institute of Health, and the Fuji Medical System (see Acknowledgments).

Cells -- Morphology -- Congresses. --- Cellular signal transduction -- Congresses. --- Cellular signal transduction --- Cells --- Symporters --- Cell Physiological Phenomena --- Cell Death --- Membrane Glycoproteins --- Peptides --- Proteins --- Membrane Transport Proteins --- Cell Physiological Processes --- Biochemical Processes --- Cytoplasmic Structures --- Biological Factors --- Amino Acids, Peptides, and Proteins --- Membrane Proteins --- Phenomena and Processes --- Biochemical Phenomena --- Cytoplasm --- Chemical Processes --- Ion Pumps --- Chemicals and Drugs --- Carrier Proteins --- Chemical Phenomena --- Intracellular Space --- Cellular Structures --- Anatomy --- Ion Channels --- Intercellular Signaling Peptides and Proteins --- Signal Transduction --- Cytoskeleton --- Sodium-Potassium-Chloride Symporters --- Cell Size --- Apoptosis --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Animal Biochemistry --- Morphology --- Life sciences. --- Human physiology. --- Molecular biology. --- Neurosciences. --- Cell biology. --- Neurobiology. --- Life Sciences. --- Cell Biology. --- Human Physiology. --- Molecular Medicine. --- Life Sciences, general. --- Neurosciences --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Neural sciences --- Neurological sciences --- Medical sciences --- Nervous system --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Human biology --- Physiology --- Human body --- Biosciences --- Sciences, Life --- Science --- Organisms --- Cytology --- Cytology. --- Medicine. --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians