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The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorder

Neuropathology --- Neurosciences --- Neurology --- History

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Neurosciences --- Anatomy --- Neurology

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Die Entstehungsbedingungen der Schizophrenie, einer meist chronisch verlaufenden psychobiologischen Erkrankung, unter der mindestens 1% der Weltbevölkerung leidet, sind trotz intensiver Forschungen nach wie vor unbekannt. Die vorliegende Monographie legt ein Erklärungsmodell der Schizophrenie vor, wobei sich die molekulare Hypothese auf die Störung der Hirnfunktionen übertragen lässt und davon die schizophrenen Symptome sowie das Wirklichkeitserleben dieser Patienten abgeleitet werden kann. Ferner kann die Theorie des Verlustes der Selbstgrenzen zumindest auf der molekularen Ebene experimentell überprüft werden. Zum besseren Verständnis des schizophrenen Wirklichkeitserlebens wird der Verlust der Selbstgrenzen auch durch psychologische, physiktheoretische, philosophische, kommunikationstheoretische und psychologische Konzepte erklärt. Besonders beeindruckend sind die Fallbeispiele. Da die Theorie experimentell überprüfbar ist, ist ein völlig neuer Ansatz der Behandlung der Schizophrenie möglich.

Psychiatry. --- Neurosciences. --- Psychopharmacology. --- Molecular biology. --- Biological psychology. --- Psychiatry. --- Neurosciences. --- Psychopharmacology. --- Molecular Medicine. --- Biological Psychology.

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Although numerous genomic studies of stroke have examined such factors as stroke inheritance, chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain injury, repair, and recovery, much work to determine the precise role of gene function in human neurological pathophysiology remains ahead. In Stroke Genomics: Methods and Reviews, leading experts in the field explore the pragmatic application of the tools of genomic and molecular biology research to the treatment of stroke. Providing the reader with cutting-edge reviews of clinical and preclinical genomics, the authors relate changes in gene expression to physiological end points-such as functional imaging paradigms-to produce a more holistic approach in which molecular biology goes hand in hand with stroke pathophysiology. Topics of special interest include stem cell transplantation, gene therapy, clinical gene/gene interaction studies, and cytokine drug discovery. Readily reproducible techniques are provided, along with ancillary methods (imaging, animal models, human genetic study design, and transgenic animal production) that can be effectively applied to gene discovery. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Stroke Genomics: Methods and Reviews shows how to successfully design, execute, and interpret preclinical and clinical molecular biological studies of stroke, work that will greatly advance its understanding, as well as rapid development of the next generation of stroke therapeutics.

Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system

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Preface 1. Introduction: A Voyage Across Time 2. An Ancient Egyptian Physician: The Dawn of Neurology 3. Hippocrates: The Brain as the Organ of the Mind 4. Galen: The Birth of Experimentation 5. Andreas Vesalius: The New ""Human"" Neuroanatomy 6. Rene Descartes: The Mind-Body Problem 7. Thomas Willis: The Functional Organization of the Brain 8. Luigi Galvani: Electricity and the Nerves 9. Franz Joseph Gall: The Cerebral Organs of Mind 10. Paul Broca: Cortical Localization and Cerebral Dominance 11. David Ferrier and Edward Hitzig: The Experimentalists Map the Cerebral Cortex 12. Je

Neurosciences --- Brain --- Physicians --- History --- Research --- physiology --- history --- Geschiedenis van de psychologie --- History. --- handboeken en inleidingen --- handboeken en inleidingen. --- Cerveau --- Système nerveux --- Neurosciences - History --- Brain - Research - History --- Brain - physiology --- Neurosciences - history --- Dimension historique --- Methode de recherche