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This work deals with the enormous complexity of cancer in a simple way: definitions, origins, triggering factors and the prospects of treatment. Recurring questions that are sometimes contradictory are dealt with in a simple, informal way. It is an accessible book for anyone who has the disease, his/her relatives or anyone who is interested in the subject.

Cancer --- Research. --- Cancer research --- Cancer. --- Treatment.

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Emerging as an important new volume in the renowned Cancer Drug Discovery and Development™ series, Deoxynucleoside Analogs in Cancer Therapy expertly summarizes the current status of development and application of deoxynucleoside analogs. Authoritative up-to-date reviews are presented by scientists well known in their specific areas and all contributions include valuable sound advice on structure and topics. Organized into several sections, the first part covers general aspects of drug uptake and metabolism and explains how novel technology has enabled a rapid expansion of this field. The second part is concerned with a number of specific drugs including cytarabine, gemcitabine, troxacitabine, clofarabine and Ara-G. The final section covers pharmacokinetics, prodrugs, and specific applications such as radiosensitization, gene therapy, and the use of deoxynucleoside analogs as tracers. Throughout Deoxynucleoside Analogs in Cancer Therapy, the focus is on novel aspects of deoxynucleoside analogs in the clinical context, as well as on unexpected targets of these compounds, such as their specific activity against cell cycle-dependent kinases or oncogenes. The wealth of information presented here can be used to design rational combinations aimed at inhibiting various cellular signaling pathways, or combining inhibition of various targets. Deoxynucleoside Analogs in Cancer Therapy has been designed specifically to facilitate such an interaction between various fields.

Deoxyribonucleotides --- Antineoplastic agents. --- Cancer --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Ribonucleotides, Deoxy --- Therapeutic use. --- Chemotherapy. --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Drugs --- Nucleotides --- Antineoplastic agents --- Chemotherapy --- Treatment

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apid progress in the understanding of carcinogenesis and pathology of epitheUal skin cancer has led to new strategies for the prevention Rand treatment of these malignancies. The goal of this volume is to comprehensively cover in a highly readable overview our present knowledge of pathogenetic mechanisms and molecular biology of Basal Cell and Squamous Cell Carcinomas. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in epidemiology, histology, photobiology, immunology, cytogenetics, and molecular pathol­ogy to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for clinicians and scientists interested in the biology of Basal Cell and Squamous Cell Carcinomas. The chapters are written by authors who are experts in their respective research areas, and I am gratefixl for their willingness to contribute to this book. I would also like to express my thanks to Ron Landes, Cynthia Conomos, Sara Lord and all the other members of the Landes Bioscience staff for their expertise, diligence and patience in helping me complete this work. Jorg Reichrathy Prof, Dn med. CHAPTER 1 The Epidemiology of Basal Cell and Squamous Cell Carcinoma Hao Wang and Thomas L.

Skin --- Basal cell carcinoma --- Squamous cell carcinoma --- Cancer --- Genetic aspects. --- SCC (Oncology) --- Squamous cell cancer --- Basal cell cancer --- Basal cell epithelioma --- Epithelioma, Basal cell --- Foot cell carcinoma --- Rodent ulcer --- Oncology. --- Oncology  . --- Pathology. --- Cancer Research. --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Cancer research. --- Cancer research

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Since Bailey and Cushing (1926), all brain tumor classifications have been called histogenetic. The nosographic position that the tumor types progressively acquired in the classification systems derived from the resemblance of tumor cells to those of the cytogenesis, modified whenever new information became available from different biological research fields and especially from molecular genetics. Classically, on the basis of the rough correspondence between the mature/immature aspect of tumor cells and the benign/malignant biological behavior of the tumors, the histological labels contained a prognostic significance. The supposed origin of the tumors was thus a factor for prognosis. Later on, with the concept of anaplasia (Cox, 1933; Kernohan et al., 1949) new criteria were introduced for establishing the malignancy grades of tumors. Immunohistochemistry and later molecular genetics further refined the prognostic diagnoses, substantially increasing the opportunities to recognize the cell origin of tumors, beside revealing the pathogenetic mechanisms. Prognoses became more accurate, as required by the greater and more targeted possibilities of therapy.

Brain --- Tumors. --- Pathophysiology. --- Cerebrum --- Mind --- Central nervous system --- Head --- Oncology. --- Neurosciences. --- Pathology. --- Neurosurgery. --- Neurology. --- Medicine. --- Cancer Research. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Medicine --- Nervous system --- Neuropsychiatry --- Nerves --- Neurosurgery --- Disease (Pathology) --- Diseases --- Medicine, Preventive --- Neural sciences --- Neurological sciences --- Neuroscience --- Tumors --- Surgery --- Health Workforce --- Cancer research. --- Neurology . --- Biomedicine, general. --- Cancer research

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Convertases are widely expressed activating enzymes involved in various physiological and pathological processes. The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting. The book will be of interest to basic researchers as well as clinicians. It will also interest those working in the cancer research area and the pharmaceutical industry, who are looking for new strategies in cancer therapy. Finally, this book is also a useful reference for researchers and clinicians pursuing research on growth factors, adhesion molecules, proteases and their implications in the processes of tumor progression, angiogenesis and metastasis.

Cancer --- Enzyme inhibitors --- Carcinogenesis --- Treatment. --- Therapeutic use. --- Molecular aspects. --- Genetic aspects. --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Molecular carcinogenesis --- Pathology, Molecular --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Inhibitors, Enzyme --- Metabolic inhibitors --- Chemical inhibitors --- Cancer therapy --- Cancer treatment --- Pathogenesis --- Antagonists --- Inhibitors --- Therapy --- Oncology. --- Oncology  . --- Chemistry. --- Cancer Research. --- Chemistry/Food Science, general. --- Physical sciences --- Tumors --- Cancer research. --- Cancer research