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Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research presents current state-of-the-art findings relevant to cellular and molecular functions of polyamines, as well as providing the underlying conceptual basis and knowledge regarding potential therapeutic-targeting polyamines and polyamine metabolism leading to the development of new therapeutic approaches for cancers and other diseases. Divided into four main parts that include polyamines in signal transduction of cell proliferation; polyamines in cellular signaling of apoptosis, carcinogenesis, and cancer therapy; polyamines in cell motility and cell-cell interactions; and polyamine homeostasis and transport, these topics are addressed by internationally recognized experts in their respective fields. This timely guide provides the whole picture of polyamines-past, present, and potential future, and offers a wealth of information regarding basic knowledge and current progress on cellular functions of polyamines and their potential clinical applications in cancer therapy. For investigators in the fields of polyamines, physiology, pharmacology, and cancer research, Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research serves as a foundation based on research and addresses the potential for subsequent applications in clinical practice.

Histology. Cytology --- farmacologie --- cytologie --- histologie

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Step-by-step, practical guidance for the acquisition, manipulation, and use of cell sources for tissue engineering

Tissue engineering is a multidisciplinary field incorporating the principles of biology, chemistry, engineering, and medicine to create biological substitutes of native tissues for scientific research or clinical use. Specific applications of this technology include studies of tissue development and function, investigating drug response, and tissue repair and replacement. This area is rapidly becoming one of the most promising treatment options for patients suffering from tissue failure.

Written by leading experts in the field, Culture of Cells for Tissue Engineering offers step-by-step, practical guidance for the acquisition, manipulation, and use of cell sources for tissue engineering. It offers a unique focus on tissue engineering methods for cell sourcing and utilization, combining theoretical overviews and detailed procedures.

Features of the text include:

Easy-to-use format with a two-part organization
Logically organized—part one discusses cell sourcing, preparation, and characterization and the second part examines specific engineered tissues
Each chapter covers: structural and functional properties of tissues, methodological principles, culture, cell selection/expansion, cell modifications, cell seeding, tissue culture, analytical assays, and a detailed description of representative studies
End-of-chapter features include useful listings of sources for reagents, materials, and supplies, with the contact details of the suppliers listed at the end of the book
A section of elegant color plates to back up the figures in the chapters

Culture of Cells for Tissue Engineering gives novice and seasoned researchers in tissue engineering an invaluable resource. In addition, the text is suitable for professionals in related research, particularly in those areas where cell and tissue culture is a new or emerging tool.

Histology. Cytology --- weefselcultuur --- cytologie --- histologie

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Mitochondrial DNA is one of the most explored genetic systems because of what it can tell us about the human past. This volume takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents the global picture of human mitochondrial DNA variation. It takes a critical look at the field, flagging the problems, as well as the successes, and always placing the mitochondrial phylogeny centre stage.

Histology. Cytology --- General biochemistry --- biochemie --- cytologie --- histologie

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Histology. Cytology --- Immunology. Immunopathology --- immunologie --- cytologie --- histologie

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Histology. Cytology --- General biochemistry --- biochemie --- cytologie --- histologie