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The use of directed cell models to study the manner in which two or more cells interact has revolutionized our understanding of protein-protein interactions in a complex milieu and has provided an invaluable platform for the identification of new molecules. In Cell-Cell Interactions: Methods and Protocols, highly skilled experts in the development and utilization of cell-cell interaction assays describe in detail their best methods-based approaches, both in vitro and in vivo, for uncovering cellular interactions at the molecular level. The protocols cover a diverse set of cell-cell interaction models in both normal and pathological states, are readily adaptable to nearly any cell type and organ system, and include primary data and outcome analysis. In addition, the protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Insightful to beginners and inspiring to seasoned professionals, Cell-Cell Interactions: Methods and Protocols provides the cutting-edge and versatile laboratory tools needed to gain a basic understanding of cell-cell interactions.

Medicine. --- Molecular Medicine. --- Health Workforce

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Der Aufbau und Betrieb von großen Biomaterialbanken wird zunehmend wichtiger: Materialbanken, die Proben langfristig für medizinisch-wissenschaftliche Analysen verfügbar machen, bieten ein großes Potential für die Klärung drängender Fragen der medizinischen Forschung. Dies gilt besonders, wenn die Proben mit Daten zum Erkrankungsverlauf der jeweiligen Patienten zusammengeführt werden. Die zunehmende Vernetzung in der biomedizinischen Forschung führt auch zum Aufbau übergreifender Daten- und Probensammlungen. Dabei stellt sich eine Vielzahl von rechtlichen und organisatorischen Fragen, für die in Deutschland bisher eine eindeutige Regelung fehlte. Die TMF hat diese Fragen aufgegriffen und in einem interdisziplinären Projekt viele Aspekte geklärt, die den Forschern nun in Form von Handlungsleitfäden und Mustertexten an die Hand gegeben werden. Der vorliegende zweite Band der TMF-Schriftenreihe beleuchtet aus juristischer Sicht die rechtlichen Rahmenbedingungen für den Aufbau und Betrieb von Biomaterialbanken: umfassendes Rechtsgutachten; Zusammenstellung der Rechtsvorschriften; Musterverträge können von der TMF zur Verfügung gestellt werden.

Medical / Research --- Medicine --- Health Workforce --- Medical --- Research

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Medicine --- Medical electronics --- Biomedical engineering --- Measurement --- Health Workforce

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Medicine --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce

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Biomedicine is the dominant organizing framework of modern medicine but it is not the only lens through which health, illness and disease can be understood. This interdisciplinary collection of essays brings together scholars from around the world who seek to probe the boundaries of biomedicine. This book is the outcome of the third global conference on ""Making Sense of: Health, Illness and Disease,"" held at St Catherine's College, Oxford, in July 2004. The papers selected for this volume take a variety of theoretical positions but share an interest in the social study of health, illness and

Medicine --- Health --- Diseases --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Epidemiology --- Pathology --- Sick --- Health Workforce --- Philosophy.