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Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, the book has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. * Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions * Includes highly significant topics relevant to basic and translational research, as well as tissue engineering * Emphasizes mechanical input and output of cells

Cells --- Biomechanics. --- Cellular Structures. --- Mechanotransduction, Cellular. --- Mechanical properties.

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About the Series: Advances in Biochemistry in Heath and Disease presents state-of-the-art discussions in cutting-edge biochemical research, offering exciting developments that impact healthcare and disease research. Volumes in the series focus on cross-disciplinary biomedical research and examine various topics in biochemistry, cell biology, molecular biology, and biomedicine. Mitochondria: The Dynamic Organelle Mitochondria: The Dynamic Organelle focuses on the function of the mitochondria and the organelle’s role in cellular pathology. While the traditional function of the mitochondria is metabolic, recent cutting-edge studies have uncovered a central role for mitochondria in cell signaling, cell survival and cell death. Mitochondria: The Dynamic Organelle presents examples of crosstalk between the mitochondria and the rest of the cell, which serve a regulatory role by modulating the levels of key metabolites, ions and oxidants or the activities of key rate-controlling enzymes. Detailed descriptions of the involvement of membrane receptors, channels, enzymes and metabolites in the cardioprotective mechanisms of the mitochondria are provided. This volume also discusses the death pathways that are initiated by the mitochondria. Novel therapeutic interventions are proposed which interfere with the death cascades, thereby rescuing the cell from mitochondria-linked apoptosis and necrotic oncosis. Mitochondria: The Dynamic Organelle is a timely contribution that addresses the reemergence of the mitochondria as a key player in cellular function and pathology. Key topics: Amino acid metabolism Carbohydrate and lipid metabolism Citric acid cycle regulation and metabolite transport Electron transport and oxidative phosphorylation Ischemic preconditioning Mitochondrial apoptosis Mitochondrial DNA damage Mitochondrial permeability transition Mitochondrial ion transporters Necrotic oncosis and mitochondrial dysfunction Peroxisome proliferators-activated receptors (PPARs) Mitochondria: The Dynamic Organelle is essential reading for researchers, molecular and cellular biologists, biochemists, physiologists and pathologists. About the Editors: Stephen W. Schaffer has been a professor of Pharmacology at the University of South Alabama, College of Medicine since 1988. He received training in mitochondrial function from the Johnson Research Foundation at the University of Pennsylvania. His research focuses on the effects of diabetes and angiotensin II on the heart, with a particular emphasis on the effects of mitochondrial DNA damage on the cardiomyocyte. He is a recipient of the Vincenzo Penagia Distinguished Scientist Award and is a fellow of the International Academy of Cardiovascular Sciences. He serves on the editorial board of Amino Acids and Molecular and Cellular Biochemistry and is editor of several books. M.-Saadeh Suleiman is currently a Professor of Cardiac Physiology at the Faculty of Medicine and Dentistry, University of Bristol. He joined the Department of Physiology in Bristol in 1988 and was one of the founders of the Bristol Heart Institute. His research is focused on myocardial protection including the role of mitochondria, and had significant impact on cardiac surgery where he was a member of the team that received the UK Hospital Doctor Award in 2005 for innovative surgery. He was a recipient of a Fulbright Fellowship and in 2003 was awarded a DSc in Physiology from the University of Bristol. He was elected twice to the executive committee of the British Society of Cardiovascular Research (1998-2004).

Life Sciences. --- Biochemistry, general. --- Molecular Medicine. --- Cell Biology. --- Developmental Biology. --- Life sciences. --- Medicine. --- Biochemistry. --- Cytology. --- Developmental biology. --- Sciences de la vie --- Médecine --- Biochimie --- Cytologie --- Biologie du développement --- Mitochondria. --- Mitochondrial pathology. --- Mitochondria --- Mitochondrial pathology --- Cell Death --- Cell Physiological Processes --- Subcellular Fractions --- Organelles --- Cytoplasmic Structures --- Cell Physiological Phenomena --- Cellular Structures --- Cytoplasm --- Phenomena and Processes --- Cells --- Anatomy --- Intracellular Space --- Biochemistry --- Biology - General --- Cytology --- Biology --- Chemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Mitochondrial disorders --- Chondriosomes --- Diseases --- Pathology --- Molecular biology. --- Cell biology. --- Metabolism --- Pathology, Cellular --- Cell organelles --- Protoplasm --- Disorders --- Development (Biology) --- Growth --- Ontogeny --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Cell biology --- Cellular biology --- Cytologists --- Composition --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Medicine --- Biomedical Research. --- Developmental Biology and Stem Cells. --- Research. --- Biological research --- Biomedical research

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Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences. Key Features Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels Uses schematic diagrams to illustrate important concepts in biophysics Written by leading researchers in the area of ion channel investigations.

Biophysics. --- Ion channels. --- Biology --- Health & Biological Sciences --- Cytology --- Ion channels --- Biophysics --- Metabolism --- Electrophysiological Phenomena --- Membrane Transport Proteins --- Biophysical Phenomena --- Nervous System Physiological Phenomena --- Membrane Glycoproteins --- Cell Physiological Phenomena --- Cellular Structures --- Carrier Proteins --- Physiological Phenomena --- Phenomena and Processes --- Metabolic Phenomena --- Cells --- Membrane Proteins --- Physical Phenomena --- Musculoskeletal and Neural Physiological Phenomena --- Proteins --- Anatomy --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Cell Membrane --- Membrane Potentials --- Ion Channels --- Cell Membrane Permeability --- Biological Transport --- Biological physics --- Channels, Ion --- Physics. --- Neurosciences. --- Biotechnology. --- Biochemistry. --- Neurobiology. --- Biological physics. --- Biomedical engineering. --- Biophysics and Biological Physics. --- Biomedical Engineering. --- Animal Biochemistry. --- Medical sciences --- Physics --- Clinical engineering --- Medical engineering --- Bioengineering --- Engineering --- Medicine --- Neurosciences --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Chemical engineering --- Genetic engineering --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Natural philosophy --- Philosophy, Natural --- Physical sciences --- Dynamics --- Composition --- Biological transport, Active --- Ion-permeable membranes --- Membrane proteins --- Biological and Medical Physics, Biophysics. --- Biomedical Engineering and Bioengineering.