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This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Ethics and addiction --- Pharmacology. Therapy

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Ethics and addiction --- Psychiatric nursing --- verslaving --- drugs

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Ethics and addiction --- Social policy --- Biotechnology

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Veterinary Toxicology is a unique single reference that teaches the basic principles of veterinary toxicology to any student at the DVM, MS or PhD level and will continue to serve as a clinical reference for practicing veterinary toxicologists, poison control centers, marine biologists, environmentalists, and animal scientists. While most comparable texts are primarily directed toward the field of human toxicology, this is the one text needed to thoroughly prepare future veterinarians on the newest approaches for diagnosing poisoning cases in all animals from chemicals and plants of a diverse nature as a result of inadvertent, accidental, or malicious intents. Many chapters are provided on topics not covered in any previous books such as target organ toxicity, radiation and radioactive materials, FDA regulatory issues, and ethics in veterinary toxicology. * Problem solving strategies are offered for treatment as well as in-depth knowledge of the basic mechanisms of veterinary toxicology. * For the first time the specifics of the effects toxins have on different animals and the resulting condition is discussed. For example, acetaminophen affects dogs by causing liver damage but causes red blood cell damage in cats. * Provides a comprehensive coverage of chemical terrorism, epidemiology, regulatory issues and the law making this text extremely timely.

Ethics and addiction --- Toxicology --- Veterinary pharmacology --- Veterinary medicine

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Ethics and addiction --- Social policy --- Hygiene. Public health. Protection --- Toxicology