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Cell Physiology. --- Electron microscopy. --- Microscopy, Electron --- Methods.

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A comprehensive guide to the revolutionary area of systems biology and its application in cell culture engineering, this volume presents an overall picture of the current topics central to structural and functional genomics, proteomics, metabolomics and bioinformatics, including such hot topics as RNAi, metabolic engineering and unfolded protein response. It includes reviews of the cellular response of environmental modulation such as low temperature and osmolarity, critical assessments of the applications of metabolomics and fluxomics approaches, examination of the utility of modulation of key genes and a presentation of a theory of chemical organisation which provides a new view of the system's structure. The clearly written chapters by experts in the field describe methods applicable to investigating the unique facets of cell culture. The book should be of interest to all those working in cell culture development and drug discovery in pharmaceutical and biotechnology companies as well as in academic institutions. It provides an invaluable resource for students and researchers in biotechnology, cell culture, genomics and bioinformatics.

Cell physiology. --- Biological systems. --- Biosystems --- Systems, Biological --- Biology --- System theory --- Systems biology --- Cell function --- Cytology --- Physiology --- Philosophy

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Exocytosis is a fundamental cellular process that is used by eukaryotic cells to release a variety of biological compounds including peptide hormones and neurotransmitters or to insert specific lipids and proteins in the plasma membrane. In recent years, a multidisciplinary approach promoted an extraordinary progress in the understanding of the molecular mechanisms regulating exocytosis. This led to the discovery of a large number of components belonging to the machinery that governs the fusion of secretory vesicles with plasma membranes in different cell systems, including neuronal and endocrine cells. The basic machinery required for vesicle fusion turned out to be well conserved through evolution from yeast to man. So far, because of the large number of components involved, understanding of the molecular basis of exocytosis has remained the privilege of a relatively small group of specialists. This book, written by recognized experts in the field aims at clarifying for a non-specialist audience the role of the key players in the exocytotic process not only in neuronal and endocrine cells but also in a variety of other relevant cell systems. The book represents a unique collection of up-to-date reviews that will introduce researchers and students to the forefront of this rapidly moving and fascinating field.

Exocytosis. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Reverse pinocytosis --- Cell physiology --- Cytology. --- Neurobiology. --- Neurosciences. --- Cell Biology. --- Neurosciences --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Cell biology.

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Cell motility is a fascinating example of cell behavior which is fundamentally important to a number of biological and pathological processes. It is based on a complex self-organized mechano-chemical machine consisting of cytoskeletal filaments and molecular motors. In general, the cytoskeleton is responsible for the movement of the entire cell and for movements within the cell. The main challenge in the field of cell motility is to develop a complete physical description on how and why cells move. For this purpose new ways of modeling the properties of biological cells have to be found. This long term goal can only be achieved if new experimental techniques are developed to extract physical information from these living systems and if theoretical models are found which bridge the gap between molecular and mesoscopic length scales. Cell Motility gives an authoritative overview of the fundamental biological facts, theoretical models, and current experimental developments in this fascinating area.

Cells --- Motility. --- Cell motility --- Cell movement --- Cellular movement --- Motility of cells --- Biomechanics --- Cell physiology --- Movement --- Cytology. --- Biomedical engineering. --- Human physiology. --- Biological and Medical Physics, Biophysics. --- Cell Biology. --- Biomedical Engineering and Bioengineering. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Biophysics. --- Biological physics. --- Cell biology. --- Biological physics --- Physics

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Sports ophthalmology --- Sensation --- Ocular Physiological Processes --- Light Signal Transduction --- Medicine --- Nervous System Physiological Processes --- Signal Transduction --- Psychophysiology --- Health Occupations --- Ocular Physiological Phenomena --- Psychological Phenomena and Processes --- Nervous System Physiological Phenomena --- Cell Physiological Processes --- Biochemical Processes --- Disciplines and Occupations --- Phenomena and Processes --- Biochemical Phenomena --- Psychiatry and Psychology --- Cell Physiological Phenomena --- Chemical Processes --- Musculoskeletal and Neural Physiological Phenomena --- Chemical Phenomena --- Vision, Ocular --- Sports Medicine --- Health & Biological Sciences --- Ophthalmology & Optometry --- Medicine, Sport --- Medicine, Sports --- Sport Medicine --- Psychology, Sports --- Physical Conditioning, Human --- Light Signal Transduction, Visual --- Ocular Vision --- Visual Light Signal Transduction --- Visual Phototransduction --- Visual Transduction --- Vision --- Phototransduction, Visual --- Transduction, Visual --- Eye --- Ophthalmology --- Visual Perception --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Molecular Biology --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiology --- System Physiology, Nervous --- Nervous System --- Eye Physiology --- Ocular Physiologic Process --- Ocular Physiological Concepts --- Ocular Physiological Phenomenon --- Ocular Physiological Process --- Physiology of the Eye --- Physiology, Ocular --- Visual Physiology --- Ocular Physiologic Processes --- Ocular Physiology --- Concept, Ocular Physiological --- Concepts, Ocular Physiological --- Ocular Physiological Concept --- Phenomena, Ocular Physiological --- Phenomenon, Ocular Physiological --- Physiologic Process, Ocular --- Physiologic Processes, Ocular --- Physiological Concept, Ocular --- Physiological Concepts, Ocular --- Physiological Process, Ocular --- Physiological Processes, Ocular --- Physiology, Eye --- Physiology, Visual --- Process, Ocular Physiologic --- Process, Ocular Physiological --- Processes, Ocular Physiologic --- Processes, Ocular Physiological --- Health Professions --- Health Occupation --- Health Profession --- Profession, Health --- Professions, Health --- Occupations --- Mind-Body Relationship (Physiology) --- Physiologic Psychology --- Physiological Psychology --- Psychology, Physiologic --- Mind-Body Relations (Physiology) --- Psychology, Physiological --- Mind Body Relations (Physiology) --- Mind Body Relationship (Physiology) --- Mind-Body Relation (Physiology) --- Mind-Body Relationships (Physiology) --- Physiologic Psychologies --- Psychologies, Physiologic --- Relation, Mind-Body (Physiology) --- Relations, Mind-Body (Physiology) --- Relationship, Mind-Body (Physiology) --- Relationships, Mind-Body (Physiology) --- Psychosomatic Medicine --- Mind-Body Relations, Metaphysical --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Cell Signaling --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Health Workforce --- Phototransduction --- Signal Transduction, Light --- Transduction, Light Signal --- Photoreceptors, Plant --- Organoleptic --- Sensory Function --- Function, Sensory --- Functions, Sensory --- Sensations --- Sensory Functions --- Perception --- Sports medicine --- physiology