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Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs. These volumes represent a comprehensive guide to prodrugs and will guide the reader through the current status of the prodrug concept and its many applications and to highlight its many successes in overcoming formulation and delivery of problematic drugs.

Pharmacology. Therapy --- farmacologie --- toxicologie

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Il processo di identificazione è per una droga vegetale di enorme importanza ai fini dell'efficacia e sicurezza della stessa. Infatti la risposta terapeutica e gli effetti indesiderati sono fortemente condizionati dall'identificazione della droga e dalla presenza di contaminanti botanici. Il testo si compone di due parti; la prima sintetizza gli aspetti diagnostici che indirizzano verso il riconoscimento della droga vegetale, mentre la seconda descrive gli aspetti macro- e microscopici della droga ed i saggi chimici e farmacologici che consentono con certezza l'identificazione della stessa. Infine, l'ultima parte riporta alcuni esempi di cromatogrammi e di tracciati di organi isolati. Il volume sarà utile agli studenti e a tutti coloro che, per la loro attività professionale, devono identificare le droghe vegetali ed evidenziare eventuali corpi vegetali estranei.

Pharmacology. Therapy --- farmacologie

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E. Bettiol, S. Clement, K.H. Krause, and M.E. Jaconi: Embryonic and Adult Stem-Cell Derived Cardiomyocytes: Lessons from in vitro Models N. Toda, K. Ayajiki: Phylogenesis of Constitutively Formed Nitric Oxide in Non-Mammals S. Huang and J. Wikswo: Dimensions of Systems Biology S. C. Sinha and S.R. Sprang: Structures, Mechanism, Regulation and Evolution of Class III Nucleotidyl Cyclases

Human physiology --- farmacologie --- fysiologie

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Pharmacology. Therapy --- farmacologie --- toxicologie

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Human physiology --- farmacologie --- fysiologie