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Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.
Oxidation, Physiological. --- Oxidation. --- Autoxidation --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Toxicology. --- Chemistry. --- Cytology. --- Pharmacology/Toxicology. --- Chemistry/Food Science, general. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Physical sciences --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Cell biology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive text on the subject. This book is unique, due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. I hope this book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research.
Oxidation, Physiological. --- Carcinogenesis. --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Pathogenesis --- Oncology. --- Oncology . --- Human genetics. --- Medicine. --- Toxicology. --- Cancer Research. --- Human Genetics. --- Molecular Medicine. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Genetics --- Heredity, Human --- Physical anthropology --- Tumors --- Toxicology --- Health Workforce --- Cancer research. --- Molecular biology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Physiological effect
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