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Under the name of programmed cell death (PCD) are included diverse molecular mechanism of cell suicide which play an essential role in the development of multicellular organisms. The best known PCD mechanism in multicellular organisms is called apoptosis. However, recent studies indicate that PCD is also present in protozoa and unicellular eukaryotes. The eleven chapters of this book give the reader a comprehensive update of the progress in the understanding of the mechanisms of PCD in protozoa. The chapters have been written by experts in this field of research and are arranged following an evolutionary point of view starting with PCD in protists and ending with PCD in ciliated protozoa.

Protozoa --- Physiology. --- Physiology --- Medicine. --- Biomedicine general. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Molecular biology. --- Biomedicine, general. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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Retinal and choroidal angiogenesis are the leading causes of irreversible vision loss in developed countries. For this reason, ocular angiogenesis is an intensely studied process, and the field is advancing at an astounding pace. It has become increasingly difficult to manage the vast amount of information generated by the growing group of interested investigators, thus a resource is needed that distills and summarizes our progress to date. Retinal and Choroidal Angiogenesis provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Renowned academic scientists, pharmaceutical scientists, and clinician-scientists have contributed chapters identifying the cellular and molecular mechanisms of retinal and choroidal angiogenesis; defining animal models of these pathologic processes; or describing the application of current tools, techniques, and theories to disease pathogenesis in humans suffering from conditions characterized by ocular angiogenesis. Additionally, novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. Retinal and Choroidal Angiogenesis emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance. The result is a reference work appealing to ophthalmologists interested in clinical applications, as well as to basic scientists interested in the cellular and molecular mechanisms of angiogenesis, both in the context of ocular and non-ocular conditions.

Choroid --- Eye --- Neovascularization. --- Retina --- Diseases. --- Blood-vessels. --- Angiogenesis --- Blood-vessels --- Growth --- Oncology. --- Oncology  . --- Medicine. --- Cancer Research. --- Molecular Medicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Cancer research. --- Molecular biology. --- Biomedicine, general. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research

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An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles. .

Chemistry. --- Molecular pharmacology --- Molecular biology --- Pharmacology --- Physical sciences --- Toxicology. --- Medicine. --- Neurosciences. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Health Workforce --- Pharmacology. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Drugs.

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Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. With the discovery of key mechanisms that are involved in mediating PCD and in promoting resistance to therapy, design of therapeutic approaches for promoting tumor-selective cell death has risen dramatically. With this book, we give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents. Additionally, this book will be a important educational source for PhD students specializing in cell biology, immunology and MD students interested in Oncology and Cancer Therapeutics.

Apoptosis. --- Cell death. --- Oncology. --- Cytology. --- Medicine. --- Immunology. --- Oncology  . --- Cancer Research. --- Cell Biology. --- Molecular Medicine. --- Tumors --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cancer research. --- Cell biology. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research

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Proteomics --- Biochimie --- Biophysique --- Biologie moléculaire --- Proteomics. --- Biochemistry --- Biophysics --- Technique --- instrumentation. --- methods. --- instrumentation --- methods --- Mechanobiology --- Molecular biology --- Proteins --- Genomics --- Protéomique --- Protéomique. --- Molecular biochemistry --- Molecular biophysics --- Biomolecules --- Systems biology --- Biological physics --- Biology --- Medical sciences --- Physics --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Composition --- Technique.