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"Bone Metastases: A Translational and Clinical Approach" serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume: describes the molecular and cellular mechanisms involved in the formation of bone metastases, comments on the role of angiogenesis, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.

Bone metastasis. --- Bones -- Cancer. --- Bone metastasis --- Neoplastic Processes --- Bone Diseases --- Neoplasms by Site --- Neoplasms --- Pathologic Processes --- Musculoskeletal Diseases --- Diseases --- Pathological Conditions, Signs and Symptoms --- Bone Neoplasms --- Neoplasm Metastasis --- Medicine --- Health & Biological Sciences --- Oncology --- Bones --- Cancer. --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Medicine. --- Cancer research. --- Oncology. --- Biomedicine. --- Cancer Research. --- Metastasis --- Cancer --- Oncology  . --- Tumors --- Cancer research

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L’osteoporosi è una complessa condizione patologica che può presentarsi in tutte le fasce di età, alla cui insorgenza concorrono molteplici fattori. Ne deriva pertanto la necessità di una rigorosa conoscenza eziopatogenetica fondamentale, oltre che clinica e diagnostica. Le conoscenze sempre più avanzate nel campo del metabolismo osseo, della clinica e farmacologia, hanno condizionato e reso necessario un adeguamento tecnico da parte dei medici specialisti ed in particolare del radiologo, in passato focalizzato sul solo aspetto diagnostico e oggi sempre più proiettato verso nuove prospettive di studio. L’opera si articola in sei parti distinte: dalla biologia, istologia e fisiopatologia del tessuto osseo (Parte I) si passa alla semeiotica, epidemiologia, fattori di rischio e prevenzione dell’osteoporosi (Parte II) e successivamente alla fisiopatologia, genetica e clinica dell’osteoporosi e delle malattie metaboliche dell’osso (Parte III). Di significativo impatto risulta la Parte IV, focalizzata sui diversi aspetti diagnostici dell’osteoporosi (diagnostica clinica, radiologica e di medicina nucleare) e resa ancora più preziosa da un’eccellente iconografia, quanto mai dimostrativa e scelta con rigorosa cura. Nella Parte V e nella Parte VI vengono infine trattati rispettivamente la terapia e le complicanze ortopediche e riabilitazione fisica. Si tratta di un testo chiaro, caratterizzato da una bibliografia precisa e aggiornata e da un’iconografia curata nei minimi particolari, da cui traspaiono l’esperienza e l’elevata capacità didattica degli Autori, sicuramente utile e interessante per tutti coloro che nell’ambito della propria attività professionale hanno necessità di approfondire le tematiche inerenti l’osteoporosi e le malattie del metabolismo osseo.

Bones -- Diseases -- Diagnosis. --- Bones -- Imaging. --- Joints -- Diseases -- Diagnosis. --- Joints -- Imaging. --- Skeleton --- Connective Tissue --- Bone Diseases --- Musculoskeletal Diseases --- Musculoskeletal System --- Tissues --- Diseases --- Anatomy --- Bone and Bones --- Bone Diseases, Metabolic --- Osteoporosis --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Osteoporosis. --- Bones --- Metabolism --- Disorders. --- Metabolic bone disease --- Medicine. --- Radiology. --- Endocrinology. --- Metabolic diseases. --- Rheumatology. --- Orthopedics. --- Medicine & Public Health. --- Imaging / Radiology. --- Diagnostic Radiology. --- Metabolic Diseases. --- Vitamin D deficiency --- Radiology, Medical. --- Orthopaedics --- Orthopedia --- Surgery --- Internal medicine --- Hormones --- Connective tissues --- Joints --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Endocrinology . --- Radiological physics --- Physics --- Radiation