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Noyau cellulaire --- nucleus --- Numération cellulaire --- Cell counting --- Chromatine --- Chromatin --- Séquence nucléotidique --- Nucleotide sequence --- Cytogénétique --- cytogenetics --- 577.112 --- Proteins --- 577.112 Proteins
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Epigenesis --- Genomics --- Chromatin --- DNA --- Chromatin. --- DNA. --- Epigenesis. --- Genomics. --- Epigenesis, Genetic. --- Comparative Genomics --- Comparative Genomic --- Genomic, Comparative --- Genomics, Comparative --- Human Genome Project --- Genome --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation --- Genome research --- Genomes --- Molecular genetics --- Embryology --- Evolution (Biology) --- Genetics --- Deoxyribonucleic acid --- Desoxyribonucleic acid --- Thymonucleic acid --- TNA (Nucleic acid) --- Deoxyribose --- Nucleic acids --- Genes --- Chromosomes --- Nucleoproteins --- Research --- Épigénèse --- Génomique --- Chromatine --- ADN
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The Greek word apoptosis was used first by Hippocrates as a synonyme of dislocations of the bones, structural changes related to tissue, by Marcus Aurelius in political and social context as failure and decline. The physician Galen extended the medical meaning of apoptosis to wound healing and inflammation. Apoptosis, or cell suicide is an integral part of life cycle of plants and animals indicated by the loss of 140-190g (50-70 billion) cells each day in the human adult, amounting to the body weight in one year. The growing interest in apoptosis is indicated by the number of scientific publications since the 1990s which is now more than 140,000 and will exceed 160,000 by the end of 2008. The unique feature of this book is the use of synhronized and reversibly permeabilized cells allowing to visualize the dynamic nature of chromatin condensation through transitory chromatin and chromosomal forms including changes upon genotoxic treatment, which were not seen earlier. The chromatin condensation process is illustrated from string (DNA) to rope (chromosomes) in more than 160 figures. The interdisciplinary nature of studies summarized in the book facilitate the global view of readers interested in the higher order structure of nucleic acids. The wealth of additional information will attract a wide population of readers. The natural audience engaged in DNA research such as genetics, cell biology, biochemistry, molecular biology will find that it contains essential material.
Apoptosis. --- Chromatin. --- Apoptosis --- Chromatin --- Nucleoproteins --- Chromosome Structures --- Cell Death --- Genetic Structures --- Proteins --- Chromosomes --- Cell Physiological Processes --- Intranuclear Space --- Amino Acids, Peptides, and Proteins --- Cell Physiological Phenomena --- Genetic Phenomena --- Cell Nucleus Structures --- Chemicals and Drugs --- Phenomena and Processes --- Cell Nucleus --- Intracellular Space --- Cellular Structures --- Cells --- Anatomy --- Biology --- Biology - General --- Cytology --- Health & Biological Sciences --- DNA --- Research. --- Deoxyribonucleic acid --- Desoxyribonucleic acid --- Thymonucleic acid --- TNA (Nucleic acid) --- Medicine. --- Cancer research. --- Oncology. --- Cell biology. --- Microscopy. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Biological Microscopy. --- Deoxyribose --- Nucleic acids --- Genes --- Cell death --- Oncology . --- Cytology. --- Analysis, Microscopic --- Light microscopy --- Micrographic analysis --- Microscope and microscopy --- Microscopic analysis --- Optical microscopy --- Optics --- Tumors --- Cell biology --- Cellular biology --- Cytologists --- Cancer research
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Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times. The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease. The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum.
Medicine. --- Epigenesis --- Genomics --- Chromatin --- DNA --- Animal Anatomy & Embryology --- Cytology --- Zoology --- Biology --- Health & Biological Sciences --- Epigenesis. --- Genomics. --- Genome research --- Genomes --- Research --- Biomedicine. --- Biomedicine general. --- Molecular genetics --- Embryology --- Evolution (Biology) --- Genetics --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general.
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