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Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Adenosine -- Receptors. --- Pharmacokinetics. --- Purinergic P1 Receptor Antagonists. --- Receptors, Purinergic P1 -- therapeutic use. --- Adenosine --- Receptors, Purinergic --- Kinetics --- Pharmacological Phenomena --- Purinergic Antagonists --- Metabolic Phenomena --- Receptors, G-Protein-Coupled --- Physiological Phenomena --- Biochemical Phenomena --- Phenomena and Processes --- Purinergic Agents --- Receptors, Cell Surface --- Receptors, Neurotransmitter --- Neurotransmitter Agents --- Membrane Proteins --- Chemical Phenomena --- Physiological Effects of Drugs --- Molecular Mechanisms of Pharmacological Action --- Proteins --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Chemical Actions and Uses --- Chemicals and Drugs --- Receptors, Purinergic P1 --- Pharmacokinetics --- Purinergic P1 Receptor Antagonists --- Health & Biological Sciences --- Human Anatomy & Physiology --- Animal Biochemistry --- Pharmacy, Therapeutics, & Pharmacology --- Receptors --- Receptors. --- Drug kinetics --- Drugs --- Kinetics, Drugs --- Adenocard --- Adenoscan --- Medicine. --- Human physiology. --- Pharmacology. --- Cell biology. --- Biomedicine. --- Pharmacology/Toxicology. --- Human Physiology. --- Cell Biology. --- Chemical kinetics --- Pharmacology --- Purine nucleosides --- Ribonucleosides --- Metabolism --- Toxicology. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Human biology --- Medical sciences --- Physiology --- Human body --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect