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Connexins: A Guide is a practical and valuable reference and text covering a wide scope of information about the connexin family of membrane channel proteins. The editors and contributing authors intend for this cutting-edge work to be informative to scientists wishing to learn about the field, as well as to those who are active researchers in this area. Connexins: A Guide masterfully addresses specific needs of the scientific community; it is a comprehensive and comprehensible narrative of the uncommonly diverse connexin field, making previously hard-to-find information easily accessible, while also presenting intelligible insights into the extensive experimental methods and conceptual frameworks necessary to appreciate and understand the important roles that connexin channel proteins play in health and disease.

Cytology. --- Human physiology. --- Toxicology. --- Connexins --- Membrane Transport Proteins --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Animal Biochemistry --- Cytology --- Connexins. --- Membrane proteins. --- Life sciences. --- Pharmacology. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Pharmacology/Toxicology. --- Human Physiology. --- Membranes (Biology) --- Membrane proteins --- Gap junctions (Cell biology)

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HANDBOOK OF MODERN BIOPHYSICS Series Editor Thomas Jue, PhD Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-science students or researchers can learn fundamental concepts and the application of new techniques in addressing biomedical challenges. Chapters explicate the conceptual framework of the physics formalism and illustrate the biomedical applications. With the addition of problem sets, guides to further study, and references, the interested reader can continue to explore independently the ideas presented. Volume II: Biomembrane Frontiers: Nanostructures, Models, and the Design of Life Editors: Roland Faller, PhD, Thomas Jue, PhD, Marjorie L. Longo, PhD, and Subhash H. Risbud, PhD In Biomembrane Frontiers: Nanostructures, Models, and the Design of Life, prominent researchers have established a foundation for the study of biophysics related to the following topics: Perspectives: Complexes in Liquids, 1900–2008 Molecular Theory Applied to Lipid Bilayers and Lipid–Protein Interactions Membrane Elasticity and Mediated Interactions in Continuum Theory: A Differential Geometric Approach Structure and Dynamics of Lipid Monolayers: Theory and Applications Multiscale Modeling of Supported Lipid Bilayers Collective Dynamics in Lipid Membranes: From Pore Formation to Flip-Flops Spatiotemporal Organization of Spin-Coated Supported Model Membranes Nanopore Analysis of Nucleic Acids: Single-Molecule Studies of Molecular Dynamics, Structure, and Base Sequence Complex Applications of Simple FRAP on Membranes Punching Holes in Membranes: How Oligomeric Pore-Forming Proteins and Lipids Cooperate to Form Aqueous Channels in Membranes Morphogens, Membranes and Mechanotransduction in Articular Cartilage Lifecycle of a Lipoprotein from a Biophysical Perspective Targeting Apolipoproteins in Magnetic Resonance Imaging About the Editors The editors are internationally recognized biomembrane experts and have published extensively on the structure, dynamics, and function of model and cellular membranes. Roland Faller is an Associate Professor and the Joe & Essie Smith Endowed Chair in the Department of Chemical Engineering & Materials Science at the University of California Davis. He develops and uses modern molecular simulation techniques for soft condensed matter systems, particularly biomembranes. Thomas Jue is a Professor in the Department of Biochemistry and Molecular Medicine at the University of California Davis. He develops and applies magnetic resonance techniques to study biochemical regulation in vivo. Marjorie L. Longo is a professor in the Department of Chemical Engineering and Materials Science at the University of California Davis. She applies microscopy techniques to study surface and transport properties of lipid bilayers and monolayers. Subhash H. Risbud is the Blacutt-Underwood Distinguished Professor of Materials Science in the Department of Chemical Engineering and Materials Science at the University of California at Davis and a Visiting Professor at Stanford University. His group develops new materials for nano- and biotechnology. The materials include glasses, ceramics, and nanoporous substrates for biological membranes.

Lipoproteins -- Congresses. --- Membrane Lipids -- Congresses. --- Membrane Proteins -- Congresses. --- Membranes -- Congresses. --- Membranes (Biology). --- Nanostructures -- Congresses. --- Membranes (Biology) --- Manufactured Materials --- Proteins --- Lipids --- Tissues --- Publication Formats --- Membrane Lipids --- Membrane Proteins --- Congresses --- Lipoproteins --- Nanostructures --- Membranes --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Publication Characteristics --- Technology, Industry, and Agriculture --- Anatomy --- Technology, Industry, Agriculture --- Biology --- Cytology --- Health & Biological Sciences --- Biochemistry. --- Biomedical engineering. --- Cytology. --- Physics. --- Cell biology --- Cellular biology --- Clinical engineering --- Medical engineering --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Natural philosophy --- Philosophy, Natural --- Composition --- Cell biology. --- Biophysics. --- Biological physics. --- Biophysics and Biological Physics. --- Biochemistry, general. --- Cell Biology. --- Chemistry --- Medical sciences --- Physical sciences --- Dynamics --- Cells --- Cytologists --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Biological and Medical Physics, Biophysics. --- Biological physics --- Physics

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Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.

Drug receptors. --- G proteins. --- Ligands (Biochemistry). --- G proteins --- Ligands (Biochemistry) --- Drug receptors --- Investigative Techniques --- Proteins --- Chemistry, Pharmaceutical --- Cell Physiological Processes --- Metabolic Phenomena --- Laboratory Chemicals --- Receptors, Cell Surface --- Biochemical Processes --- Natural Science Disciplines --- Amino Acids, Peptides, and Proteins --- Biochemical Phenomena --- Membrane Proteins --- Specialty Uses of Chemicals --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Pharmacology --- Chemical Processes --- Phenomena and Processes --- Cell Physiological Phenomena --- Chemicals and Drugs --- Chemical Phenomena --- Biological Science Disciplines --- Chemical Actions and Uses --- Chemistry --- Drug Discovery --- Ligands --- Metabolism --- Receptors, G-Protein-Coupled --- Signal Transduction --- Receptors, Drug --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neurology --- Animal Biochemistry --- Drugs --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Receptors --- Medicine. --- Human physiology. --- Neurosciences. --- Pharmacology. --- Neurology. --- Neurobiology. --- Biomedicine. --- Pharmacology/Toxicology. --- Human Physiology. --- Cell receptors --- Membrane proteins --- Biochemistry --- Toxicology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Nervous system --- Neuropsychiatry --- Neurosciences --- Chemicals --- Poisoning --- Poisons --- Neural sciences --- Neurological sciences --- Neuroscience --- Diseases --- Toxicology --- Neurology . --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect

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Tumor necrosis factor (TNF) superfamily is a rapidly growing family of cytokines that interacts with a corresponding superfamily of receptors. Ligand-receptor interactions of this superfamily are involved in numerous biological processes ranging from hematopoiesis to pleiotropic cellular responses, including activation, proliferation, differentiation, and apoptosis. The particular response depends on the receptor the cell type, and the concurrent signals received by the cell. Worldwide interest in the TNF field surged dramatically early in 1984 with the cloning and defining of the profound cellular effects of the first member of this family, TNFa. Subsequently, the major influence of TNFa on the development and functioning of the immune system was established. Today, over 20 human TNF ligands and their more than 30 corresponding receptors have been identified. Few receptors still remain orphans. What has emerged over the years is that most TNF ligands bind to one distinct receptor and some of the TNF ligands are able to bind to multiple TNF receptors, explaining to some extent the apparent disparity in the number of TNF receptors and ligands. Yet, in spite of some redundancy in TNF ligand/receptor interactions, it is clear that in vivo spatial, temporal, and indeed cell- and tissue-specific expression of both ligands and their receptors are important factors in determining the precise nature of cellular physiological and pathological processes they control. Therapeutic Targets of the TNF Superfamily presents the state-of-the art account on the role of TNF superfamily members in the pathogenesis and their use in current intervention of cancers and autoimmune disease. This text will be highly valuable for investigators to understand the disease processes regulated by TNF superfamily members and to develop effective therapeutics. A view into the future, inspired by the comprehensive work presented in this volume, predicts that researchers studying TNF superfamily members will continue to make rapid progress in identifying relevant components to the disease process and new therapeutic strategies to target many human diseases including cancers, autoimmune disease and others.

Tumor necrosis factor --Agonists --Therapeutic use. --- Tumor necrosis factor. --- Tumor necrosis factor --- Autoimmune Diseases --- Tumor Necrosis Factors --- Receptors, Tumor Necrosis Factor --- Neoplasms --- Inflammation --- Drug Therapy --- Immune System Diseases --- Diseases --- Intercellular Signaling Peptides and Proteins --- Pathologic Processes --- Cytokines --- Receptors, Cytokine --- Therapeutics --- Pathological Conditions, Signs and Symptoms --- Peptides --- Biological Factors --- Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Immunologic --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Receptors, Cell Surface --- Membrane Proteins --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Agonists --- Therapeutic use --- Therapeutic use. --- Cachectin --- Lymphotoxin --- TNF (Immunology) --- Medicine. --- Immunology. --- Biomedicine. --- Biomedicine general. --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Glycoproteins --- Growth factors --- Macrophages --- Biomedicine, general. --- Health Workforce

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The evolution in our understanding of Opioid receptors and their subtypes is intimately linked to the development of new pharmacological treatments for diseases and disorders as diverse as addiction, self-injurious behavior, pain, cancer, inflammation, eating disorders, traumatic injury, pruritis and movement disorders. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent efforts from leading international scientists and clinicians making use of the latest information emerging from the study of the opioid-receptor system. The authors use a variety of experimental and clinical approaches involving the fields of molecular biology, biochemistry, anatomy, pharmacology, behavioral neuroscience and psychiatry to illustrate rapidly developing experimental and therapeutic areas. Highlights include characterization of opioid receptors, chemistry and pharmacology of opiod antagonists for various receptor subtypes (Mu, Kappa, and Delta), discussion of therapeutic uses of opiod antagonists and exploration of innovative approaches to therapeutic drug delivery. Opioid Receptors and Antagonists: From Bench to Clinic offers a comprehensive view of recent work on opiod antagonist applications and uses in various clinical treatments. Emphasis is placed on disorders of the reward system. This volume serves as reference while also illuminating prospects for future research.

Endorphins. --- Endorphins --- Opioids --- Nervous system --- Peptides --- Central Nervous System Agents --- Mental Disorders --- Investigative Techniques --- Chemistry, Pharmaceutical --- Receptors, Neuropeptide --- Neuropeptides --- Therapeutics --- Receptors, G-Protein-Coupled --- Diseases --- Physiological Effects of Drugs --- Sensory System Agents --- Pharmacologic Actions --- Chemistry --- Therapeutic Uses --- Amino Acids, Peptides, and Proteins --- Receptors, Neurotransmitter --- Psychiatry and Psychology --- Receptors, Cell Surface --- Pharmacology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Peptide --- Peripheral Nervous System Agents --- Nerve Tissue Proteins --- Chemicals and Drugs --- Natural Science Disciplines --- Proteins --- Chemical Actions and Uses --- Membrane Proteins --- Biological Science Disciplines --- Disciplines and Occupations --- Narcotic Antagonists --- Receptors, Opioid --- Substance-Related Disorders --- Drug Discovery --- Drug Therapy --- Opioid Peptides --- Drug Delivery Systems --- Health & Biological Sciences --- Human Anatomy & Physiology --- Pharmacy, Therapeutics, & Pharmacology --- Animal Biochemistry --- Receptors --- Antagonists --- Chemotherapy --- Antagonists. --- Receptors. --- Chemotherapy. --- Opioid receptors --- Endorphin receptors --- Morphine receptors --- Narcotic receptors --- Opiate receptors --- Medicine. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Organs (Anatomy) --- Neurosciences --- Opioid peptides