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Book
Host-Pathogen Interactions : Methods and Protocols
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ISBN: 1597452041 1588298868 Year: 2009 Publisher: Totowa, NJ : Humana Press : Imprint: Humana,

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In recent decades, infectious diseases, once believed to be fairly contained, have become a vital, resurgent field of research. In Host-Pathogen Interactions: Methods and Protocols, top experts examine the relationship between the host and the pathogen, crucial in the outcome of an infection and the establishment of disease or asymptomatic, commensal colonization by organisms. The step-by-step laboratory methods and protocols of this volume study host-pathogen interaction, with a focus on fungal, bacterial and parasitic pathogens, at a molecular level in order to reveal the mechanisms of infection and to identify the vulnerabilities of the pathogen of interest. Written in the highly successful Methods in Molecular Biology™ series format, the chapters feature brief subject introductions, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Host-Pathogen Interactions: Methods and Protocols serves as an easy entry point for all those investigating the factors responsible for the pathogenicity of microorganisms.


Book
Hepatitis C : Methods and Protocols
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ISBN: 1588299708 1597453943 Year: 2009 Publisher: Totowa, NJ : Humana Press : Imprint: Humana,

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With the development of robust cell-culturing systems capable of Hepatitis C Virus replication and infection, the past decade has witnessed an explosion of innovative research directed at understanding HCV biology in the context of the authentic replicative cycle of the virus. By providing a compilation of cutting-edge research techniques currently in use in HCV labs worldwide, Hepatitis C: Methods and Protocols, Second Edition fully updates the previous edition to reflect this progress which promises to unlock the remaining vital information regarding this human pathogen and its interactions. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Fully updated and comprehensive, Hepatitis C: Methods and Protocols, Second Edition serves as a valuable reference guide for basic and clinical researchers using HCV as a model and striving to better understand this critical disease.


Book
HIV Protocols : Second Edition
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ISBN: 1588298590 1597451703 Year: 2009 Publisher: Totowa, NJ : Humana Press : Imprint: Humana,

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Despite major advances in the treatment of HIV, there are still many areas requiring additional study. These areas include ways to create efficacious, potent antiretrovirals for suppressing viral loads completely without toxic side effects, the definition of unknown drug targets while fine-tuning known targets, and the ability to better understand the interplay between viral and host factors. In HIV Protocols, Second Edition, expert researchers provide clear, state-of-the-art methods for the study of HIV. Directed toward three specific goals, this text aims to document up-to-date protocols for select aspects of HIV biology, to bring together both virological and immunological approaches in a single, convenient volume, and to present a comprehensive account of a range of techniques not available in any existing HIV protocol book. As a volume in the highly successful Methods in Molecular Biology™ series, the chapters include brief introductions to the subject, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections containing priceless tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, HIV Protocols, Second Edition is an ideal guide to the wide array of techniques used in fundamental or applied research into the biology and pathogenesis of HIV-1.


Book
Surgical pathology of the gastrointestinal system : bacterial, fungal, viral, and parasitic infections
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ISBN: 1441908609 1441908625 9786612829499 1441908617 1282829491 Year: 2009 Publisher: New York : Springer,

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Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides a unique diagnostic reference text for the pathologic diagnosis of infectious diseases of the gastrointestinal tract. Written for the practicing surgical pathologist, this text combines the superior illustrations of an atlas with carefully written prose to create a useful diagnostic companion. The text is divided into four sections covering bacterial, fungal, viral, and parasitic infections of the gastrointestinal tract. The descriptive sections of each chapter are organized into short paragraphs for easy reference and include the use of tables to compare and contrast organisms and summarize differential diagnoses. Each chapter is extensively illustrated, and contains prose discussions of diagnostic features, differential diagnoses, brief clinical descriptions, and ancillary tests that help confirm the diagnosis (i.e. immunohistochemistry, special histochemical stains, and molecular diagnostic techniques). Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides pertinent clinical, diagnostic, and epidemiologic information that will be valuable to the practicing surgical pathologist. This volume will also help surgical pathologists gain familiarity with other contributory laboratory tests that are available to help confirm diagnosis.


Book
Antimicrobial drug resistance handbook.
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ISBN: 1603275940 9786612333446 1282333445 1603275959 Year: 2009 Publisher: Totowa, N.J. : Humana,

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The volumes included in Antimicrobial Drug Resistance represent the first comprehensive, multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. The first volume, Antimicrobial Drug Resistance, Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant strains, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of currently available ones. The second volume, Antimicrobial Drug Resistance, Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious disease physician requires input from the clinical microbiologist and infection control specialist to make informed choices for the effective treatment of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious disease physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.


Book
Emerging issues and controversies in infectious disease
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ISBN: 1441927395 0387848401 9786612002847 1282002848 038784841X Year: 2009 Publisher: New York : Springer,

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This new volume of the "Emerging Infectious Diseases of the 21st Century" series is an up to date, state-of-the-art review on several important infections challenging clinicians, from the general practitioner to the various subspecialists that deals with infections. Topics were chosen to address new emerging issues and controversies in clinical infectious Disease: Issues in Central nervous System Infections Emerging issues in Head & Neck Infections Current issues in Ventilator-associated pneumonia Emerging issues in Pulmonary infections of Cystic fibrosis Re-emergence of childhood respiratory infections in adults New Concepts & emerging issues in sepsis Febrile neutropenia: management issues Emerging issues & trend in Clostriduim difficile colitis Probiotics in Infections Disease Device Related Infections Current concepts of orthopedic implants and prosthetic joint infections Combination antimicrobial therapies.


Book
Management of sepsis : the PIRO approach
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ISBN: 3642101488 3642004784 9786612364679 1282364677 3642004792 Year: 2009 Publisher: Berlin : Springer,

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Sepsis is a very important public health problem. It is widely acknowledged that the severe inflammatory response syndrome/severe sepsis paradigm fails to stratify sepsis patients adequately. This book reviews in detail how sepsis should be managed on the basis of a novel approach to staging. The PIRO (predisposing factors, infection, response, organ dysfunction) model was first proposed at the start of the decade on a theoretical basis and has now been translated into a practical approach for use at the bedside. It is loosely based on the TNM staging system for cancers, with points being allocated to each of the four aforementioned key characteristics of the septic process. The proposed PIRO framework facilitates evaluation of factors that are important in the pathogenesis of severe sepsis and in the development of treatment strategies. This book clearly explains the advantages of the PIRO approach in different settings and will be of value to all practitioners concerned with the management of sepsis.


Book
Infectious disease in the aging : a clinical handbook
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ISBN: 1617379069 1603275339 9786612333453 1282333453 1603275347 Year: 2009 Publisher: Totowa, NJ : Humana Press,

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Because aging is accompanied by a steady decline in resistance to infectious diseases, the diagnosis and treatment of these diseases in the elderly is not only much more complex, but also often quite different from that for younger patients. In Infectious Disease in the Aging: A Clinical Handbook, 2nd Edition, a panel of well-known and highly experienced geriatric physicians and infectious disease experts review the most important common infections affecting the elderly and delineate their well-proven diagnostic, therapeutic, and preventative techniques. Among the illnesses discusses are urinary tract infections, pneumonia, ocular infections, tuberculosis, and fungal and viral infections. There are detailed discussion of sepsis, infective endocarditis, intraabdominal infections, bacterial meningitis, osteomyelitis and septic arthritis, and prosthetic device infections. In addition, this 2nd edition includes new chapters on Herpes zoster, HIV/AIDS, and SARS and West Nile Virus. Comprehensive, informative, and easily accessible, Infectious Disease in the Aging: A Clinical Handbook, 2nd Edition, offers all physicians treating geriatric patients the quickest and most up-to-date guide to understanding, diagnosis, treatment, and prevention of infectious disease problems in the elderly today.


Book
Human papillomavirus : a practical guide for urologists
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ISBN: 3540709738 9786612655890 1282655892 3540709746 Year: 2009 Publisher: Berlin : Springer,

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A guide to the diagnosis and treatment of human papillomavirus (HPV)-related diseases from a urological perspective. With a strong emphasis on the clinical aspects of genital HPV infection, it is suitable for urologists and medical practitioners wishing to acquire or expand their knowledge of urologic diseases caused by HPV.


Book
Dictionary of rheumatology
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ISBN: 3211685847 3211792805 Year: 2009 Publisher: Wien ; New York : Springer,

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Rheumatic Diseases and Osteoporosis are very common diseases. Recently the prevalence of Arthritis among American citizens is documented with 20%. This dictionary provides a comprehensive list of common terms and definitions in clinical rheumatology and osteology. It contains systematical descriptions selected from diseases of the locomotor apparatus, including osteoporosis, and important laboratory findings with special reference to the immunological parameters, which are essential for a correct definition of rheumatologic disorders. Another focus is placed on general principles of the pharmacological treatment, including Biologicals and modern therapy. The book also provides information about the individual disorders from the field of mineral metabolism and metabolic osteopathy’s, and covers basic issues of rheumatic surgery as well as general entries from the fields of physical medicine and physiotherapy, including a system of functional assessment.

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