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The book recognizes the complexity of biological phenomena under investigation and treats the subject matter with a degree of mathematical rigor. Special attention is given to computer simulations for interpolation and extrapolation of electromechanical and chemoelectrical phenomena, nonlinear self-sustained electromechanical wave activity, pharmacological effects including co-localization and co-transmission by multiple neurotransmitters, receptor polymodality, and drug interactions.

Gastrointestinal system --- Gastro-intestinal system --- Gastrointestinal tract --- GI tract --- Tract, Gastrointestinal --- Tract, GI --- Alimentary canal --- Digestive organs --- Innervation --- Mathematical models. --- Computer simulation. --- Gastrointestinal Motility --- Computer Simulation. --- Gastrointestinal Tract --- Models, Biological. --- physiology. --- innervation.

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Both informative and easy to read Transanal stapling techniques for anorectal prolapse provides a comprehensive review of the current knowledge regarding the modern treatment of anorectal prolapse, with emphasis on stapled haemorrhoidopexy for prolapsing haemorrhoids, and the STARR procedure for obstructed defaecation syndrome. The first transanal stapling technique for the treatment of anorectal prolapse was presented in abstract form in 1998 by Dr A Longo. This described a novel technique for the surgical correction of prolapsing hemorrhoids. The technique has subsequently enjoyed tremendous success due to its benefits in reducing postoperative pain, shortening hospital stay, and achieving an earlier return to normal activities. It is this success that led to the development of the stapled transanal rectal resection (STARR) procedure. The book provides practical guidance in the application of the techniques with criteria for patient selection, tips and tricks for obtaining the best outcomes, and how to avoid and deal with potential complications. The views of the authors are supported by an overview of the evidence base as documented in the medical literature. A further section deals with unresolved issues of controversy and puts forward areas for ongoing research and development. Transanal stapling techniques for anorectal prolapse is aimed at higher surgical trainees who are learning for the first time the complexities of proctological practice, as well as established general surgeons and coloproctologists who encounter the conditions on a frequent basis. The complexities of the pelvic floor are increasingly recognised as demanding a combined approach with gynecologists and urologists, and the book will also appeal to practitioners in these specialities.

Rectum -- Prolapse. --- Rectum -- Surgery. --- Rectum. --- Rectal Prolapse --- Anal Canal --- Surgical Stapling --- Pelvic Organ Prolapse --- Rectal Diseases --- Intestine, Large --- Suture Techniques --- Lower Gastrointestinal Tract --- Wound Closure Techniques --- Intestines --- Prolapse --- Intestinal Diseases --- Gastrointestinal Tract --- Gastrointestinal Diseases --- Surgical Procedures, Operative --- Pathological Conditions, Anatomical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Digestive System Diseases --- Digestive System --- Pathological Conditions, Signs and Symptoms --- Anatomy --- Diseases --- Surgery - General and By Type --- Gastroenterology --- Surgery & Anesthesiology --- Medicine --- Health & Biological Sciences --- Colon (Anatomy) --- Rectum --- Surgery, Operative. --- Surgery. --- Operative surgery --- Surgery --- Surgical techniques --- Technique --- Medicine. --- Internal medicine. --- Pain medicine. --- Medicine & Public Health. --- Colorectal Surgery. --- Internal Medicine. --- Pain Medicine. --- Medicine, Internal --- Surgery, Primitive --- Algiatry --- Rectum—Surgery .

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Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides a unique diagnostic reference text for the pathologic diagnosis of infectious diseases of the gastrointestinal tract. Written for the practicing surgical pathologist, this text combines the superior illustrations of an atlas with carefully written prose to create a useful diagnostic companion. The text is divided into four sections covering bacterial, fungal, viral, and parasitic infections of the gastrointestinal tract. The descriptive sections of each chapter are organized into short paragraphs for easy reference and include the use of tables to compare and contrast organisms and summarize differential diagnoses. Each chapter is extensively illustrated, and contains prose discussions of diagnostic features, differential diagnoses, brief clinical descriptions, and ancillary tests that help confirm the diagnosis (i.e. immunohistochemistry, special histochemical stains, and molecular diagnostic techniques). Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides pertinent clinical, diagnostic, and epidemiologic information that will be valuable to the practicing surgical pathologist. This volume will also help surgical pathologists gain familiarity with other contributory laboratory tests that are available to help confirm diagnosis.

Gastrointestinal system --- Gastro-intestinal system --- Gastrointestinal tract --- GI tract --- Tract, Gastrointestinal --- Tract, GI --- Diseases. --- Pathophysiology. --- Medicine. --- Gastroenterology. --- Infectious diseases. --- Pathology. --- Medicine & Public Health. --- Infectious Diseases. --- Alimentary canal --- Digestive organs --- Emerging infectious diseases. --- Internal medicine --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Gastroenterology .

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Our gut is colonized by numerous bacteria throughout our life, and the gut epithelium is constantly exposed to foreign microbes and dietary antigens. Thus, the gut epithelium acts as a barrier against microbial invaders and is equipped with various innate defense systems. Resident commensal and foreign invading bacteria interact intimately with the gut epithelium and can impact host cellular and innate immune responses. From the perspective of many pathogenic bacteria, the gut epithelium serves as an infectious foothold and port of entry for disseminate into deeper tissues. In some instances when the intestinal defense activity and host immune system become compromised, even commensal and opportunistic pathogenic bacteria can cross the barrier and initiate local and systematic infectious diseases. Conversely, some highly pathogenic bacteria, such as those highlighted in this book, are able to colonize or invade the intestinal epithelium despite the gut barrier function is intact. Therefore, the relationship between the defensive activity of the intestinal epithelium against microbes and the pathogenesis of infective microbes becomes the basis for maintaining a healthy life. The authors offer an overview of the current topics related to major gastric and enteric pathogens, while highlighting their highly evolved host (human)-adapted infectious processes. Clearly, an in-depth study of bacterial infectious strategies, as well as the host cellular and immune responses, presented in each chapter of this book will provide further insight into the critical roles of the host innate and adaptive immune systems and their importance in determining the severity or completely preventing infectious diseases. Furthermore, under the continuous threat of emerging and re-emerging infectious diseases, the topic of gut-bacteria molecular interactions will provide various clues and ideas for the development of new therapeutic strategies.

Bacterial diseases --Molecular aspects. --- Gastrointestinal system --Diseases. --- Molecular microbiology. --- Bacterial diseases --- Gastrointestinal system --- Molecular microbiology --- Adaptive Immunity --- Bacterial Infections --- Intestines --- Immunity, Innate --- Microbiology --- Bacterial Infections and Mycoses --- Gastrointestinal Tract --- Biology --- Immunity --- Immune System Phenomena --- Diseases --- Digestive System --- Biological Science Disciplines --- Natural Science Disciplines --- Phenomena and Processes --- Anatomy --- Disciplines and Occupations --- Microbiology & Immunology --- Health & Biological Sciences --- Molecular aspects --- Bacterial diseases. --- Infections. --- Bacterial infections --- Gastro-intestinal system --- Gastrointestinal tract --- GI tract --- Tract, Gastrointestinal --- Tract, GI --- Medicine. --- Immunology. --- Medical microbiology. --- Molecular biology. --- Biomedicine. --- Medical Microbiology. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Communicable diseases --- Medical bacteriology --- Pathogenic bacteria --- Alimentary canal --- Digestive organs --- Microbiology. --- Microbial biology --- Microorganisms --- Health Workforce --- Medicine --- Biomedical Research. --- Research. --- Biological research --- Biomedical research

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Transanal Endoscopic Microsurgery: Principles and Techniques is the first book to present a complete review of an exciting developing technology. Cancer of the rectum remains a significant health problem, despite the increasing improvement of survival rates. The improvement in patient care comes from many sources: more accurate preoperative staging, aggressive neoadjuvant therapy and improved surgical techniques. Surgical extirpation continues to be the cornerstone of curative treatment of this potentially lethal disease. Transanal endoscopic microsurgery (TEM) is a technique for the performance of local excision by way of a binocular magnified operating system. Comparative trials demonstrate significantly better oncologic results for rectal cancer treated by TEM compared to conventional local excision. TEM provides a technically superior method for excision of rectal polyps and select early rectal cancers, with lower costs and fewer complications when compared to conventional approaches. The editors and chapter authors of Transanal Endoscopic Microsurgery: Principles and Techniques are the world’s leading experts on TEM and their collective clinical experience is reflected in the practically oriented approach in every chapter. The text will prove to be an asset to any colorectal or general surgeon’s library.

Rectum --Cancer --Surgery. --- Rectum --Endoscopic surgery. --- Rectum --- Rectal Neoplasms --- Endoscopy, Gastrointestinal --- Microsurgery --- Methods --- Surgical Procedures, Operative --- Endoscopy, Digestive System --- Colorectal Neoplasms --- Investigative Techniques --- Micromanipulation --- Intestine, Large --- Endoscopy --- Intestinal Neoplasms --- Rectal Diseases --- Diagnostic Techniques, Digestive System --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Intestines --- Lower Gastrointestinal Tract --- Digestive System Surgical Procedures --- Diagnostic Techniques, Surgical --- Gastrointestinal Tract --- Gastrointestinal Neoplasms --- Diagnostic Techniques and Procedures --- Intestinal Diseases --- Surgical Procedures, Minimally Invasive --- Digestive System --- Gastrointestinal Diseases --- Digestive System Neoplasms --- Diagnosis --- Digestive System Diseases --- Neoplasms by Site --- Anatomy --- Diseases --- Neoplasms --- Surgery - General and By Type --- Surgery & Anesthesiology --- Health & Biological Sciences --- Cancer --- Surgery --- Endoscopic surgery --- Endoscopic surgery. --- Microsurgery. --- Endosurgery --- Minimal access surgery --- Minimally invasive surgery --- MIS (Minimally invasive surgery) --- Operative endoscopy --- Surgical endoscopy --- Medicine. --- Surgery. --- Medicine & Public Health. --- Colorectal Surgery. --- General Surgery. --- Medical microscopy --- Surgery, Operative --- Colon (Anatomy) --- Surgery, Primitive --- Medicine --- Rectum—Surgery .