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Lung cancer is the leading cause of cancer related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery. The primary audience for this book are physicians involved in the management of lung cancer in the clinic, clinical investigators and basic scientists focused on lung cancer research, cancer biologists investigating mechanisms of metastasis, pharmaceutical and biotechnology industry professionals with an interest in development of metastasis-targeted diagnostics and therapeutics, and graduate students and postdoctoral fellows in cancer biology programs.
Biomedicine. --- Cancer Research. --- Oncology. --- Medicine. --- Médecine --- Cancérologie --- Lungs --- Metastasis. --- Lung Neoplasms. --- Neoplasm Metastasis. --- Cancer. --- Oncology . --- Tumors --- Cancer research. --- Cancer research --- Lung Neoplasms --- Neoplasm Metastasis
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With the devastating complication of cancer cells becoming simultaneously resistant to many structurally and mechanistically unrelated drugs, the efficacy of chemotherapeutic management of cancer often becomes severely limited. In Multi-Drug Resistance in Cancer, leading researchers in the field provide comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance protein, to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The extensive volume also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression, as well as techniques for detection and imaging of drug transporters, methods for investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Multi-Drug Resistance in Cancer offers a state-of-art collection of reviews and methods for both basic and clinician investigators who are interested in the vital study of cancer multi-drug resistance mechanisms and reversal strategies.
Oncology . --- Oncology. --- Drug interactions. --- Cancer Research. --- Drug Resistance.
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Allergies are caused by a person’s own IgE antibodies directed against innocuous antigens like pollen or house dust mites. Interestingly, several studies have examined the relation between allergies or level of IgE and malignancies and have found an inverse association suggesting a natural role of IgE in cancer immunosurveillance. Is it thus possible that IgE immunoglobulins could have a beneficial function against cancer besides their harmful function in allergy? If so, can we exploit this beneficial function for the development of new cancer therapies? Could oncologists learn from allergists and vice versa? This book attempts to explore step by step these interesting questions, opening a novel science field: AllergoOncology. AllergoOncology by definition aims to reveal the function of IgE-mediated immune responses against cancer cells in order to enhance the understanding of its biology and to develop novel IgE-based treatment options against malignant diseases. Cancer and IgE: Introducing the Concept of AllergoOncology opens new avenues towards IgE antibodies as key effector molecules able to confer protection against cancer development and progression. This affinity-matured class of antibody, belonging to Th2-mediated immunity, uses an exquisite panel of potent effector cells which can eradicate malignant cells. Importantly, IgE is also capable of binding to professional antigen presenting cells thereby enhancing the presentation of cancer antigens and leading to a significant anti-tumor immune response. Based on its anti-tumor efficacy, which has been shown in vitro and in preclinical models, IgE can be potentially used in human in the context passive and active cancer immunotherapy. In summary, this book, which is the first of its class, is a comprehensive volume about the evolving new field AllergoOncology.
Cancer --- Immunoglobulin E. --- IgE --- Cancer therapy --- Cancer treatment --- Carcinogenesis --- Immunological aspects. --- Treatment. --- Therapy --- Immunological aspects --- Medicine. --- Cancer research. --- Immunology. --- Oncology. --- Biomedicine. --- Cancer Research. --- Immunoglobulins --- Allergy --- Anti-immunoglobulin autoantibodies --- Oncology . --- Tumors --- Immunobiology --- Life sciences --- Serology --- Cancer research
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Over the last few years, the methods for analyzing cancer-related genes on a molecular level have changed rapidly. The advent of incredible new technology, such as automated sequencing, has served as a catalyst for many advances in the area of gene profiling, and has enabled the research community to investigate populations of cells in a given tissue. Cancer Gene Profiling: Methods and Protocols examines the world of cancer gene profiling in light of these new advances, providing highly developed microarray techniques alongside modern methods for arraying tissues and proteomics. Chapters bring together the experiences of leading scientists in each method of profiling, providing a clear overview of the ground-breaking techniques used to perform these experiments effectively. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and state-of-the-art, Cancer Gene Profiling: Methods and Protocols is a fundamental guidebook for researchers in the field of cancer gene profiling, as well as for those individuals in the area of biomedical/translational research.
Oncology . --- Oncology. --- Gene expression. --- Cancer Research. --- Gene Expression. --- Tumors --- Genes --- Genetic regulation --- Expression
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Over the past two decades, spectacular advances have been made in our understanding of the molecular genetics of cancer, leading to the pursuit of identifying genes that, when mutated, result in an increased susceptibility to the disease. In Cancer Susceptibility: Methods and Protocols, experts in the field bring together the most recent technological developments for identifying and screening cancer susceptibility genes. Divided into two clear sections, the book begins with gene identification, which updates and informs scientists working at identifying novel cancer susceptibility genes, while the second part deals with mutation screening technologies that aid scientists and clinicians working to translate this knowledge into the clinic. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Susceptibility: Methods and Protocols is a timely collection that seeks to provide researchers with the tools to predict and combat this terrible disease.
Oncology . --- Oncology. --- Human genetics. --- Cancer Research. --- Human Genetics. --- Tumors --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology
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La th matique du survivorship, en plein essor dans les pays anglo-saxons, int gre des dimensions multiples comme la recherche clinique, l pid miologie, les sciences humaines et sociales, l'education sanitaire. En France, les premiers programmes de recherche commencent voir le jour. Cet ouvrage collectif, r dig par des specialistes d'horizons vari s, se propose de faire le point sur les diff rents probl mes rencontr?'s au cours des ann es qui suivent le traitement des tumeurs solides localis es de l'adulte. Il s'adresse tous les praticiens impliqu?'s dans la prise en charge des cancers et de leu
Cancer --- Patients. --- Research. --- Cancer research --- Cancer patients --- Cancer survivors --- Survivors, Cancer
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Cancer --- Health maintenance organizations --- Health facilities --- Research --- Citizen participation. --- Cancer Research Network (Organization)
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Cancer --- Health maintenance organizations --- Health facilities --- Research --- Citizen participation. --- Cancer Research Network (Organization)
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Omics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in cancer research. The development of high-throughput technologies that permit the solution of deciphering cancer from higher dimensionality will provide a knowledge base which changes the face of cancer understanding and therapeutics. This is the first book to provide such a comprehensive coverage of a rapidly evolving area written by leading experts in the field of omics. It complies and details cutting-edge cancer research that covers the broad advances in the field and its application from cancer-associated gene discovery to drug target validation. It also highlights the potential of using integration approach for cancer research. This unique and timely book provides a thorough overview of developing omics, which will appeal to anyone involved in cancer research. It will be a useful reference book for graduate students of different subjects (medicine, biology, engineering, etc) and senior scientists interested in the fascinating area of advanced technologies in cancer research. Readership: This is a precious book for all types of readers – cancer researchers, oncologists, pathologists, biologists, clinical chemists, pharmacologists, pharmaceutical specialists, biostatisticians, and bioinformaticists who want to expand their knowledge in cancer research.
Cancer -- Research -- Technological innovations. --- Cancer -- Research. --- Medical -- Oncology. --- Medicine. --- Cancer --- Diseases --- Computational Biology --- Science --- Genetics --- Biology --- Natural Science Disciplines --- Biological Science Disciplines --- Disciplines and Occupations --- Genomics --- Research --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Technological innovations --- Technological innovations. --- Research. --- Cancer research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Cancer research. --- Human genetics. --- Proteomics. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Human Genetics. --- Tumors --- Oncology. --- Molecular biology --- Proteins --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biomedicine, general. --- Health Workforce
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Cancer genetics has revolutionized the practice of medicine as inherited genetic information helps predicts which individuals are at risk of developing various forms of cancer. Furthermore, somatically acquired genetic changes help identify therapeutic targets for patients with several common tumor types such as breast and colon cancer. Cancer Genetics reviews seminal discoveries such as genetic susceptibility to gastric cancer, ethical issues related to cancer genetics, the role of common variants in the development of breast cancer, novel genetic findings related to neuroblastoma, and the role of constitutively decreased TGF-beta signaling, which is emerging as one of the most common causes of colorectal cancer. The book has been written for all clinicians and researchers interested in cancer genetics, including oncologists, genetic counselors and cancer researchers both in academia and in industry. "Genetic alterations are a fundamental component of all cancers. This text highlights critical issues relevant for both basic scientists and clinicians. Recognized thought leaders in the field discuss current knowledge and future challenges." - Steven T. Rosen, M.D., Series Editor.
Cancer -- Genetic aspects. --- Cancer. --- Neoplasms -- genetics. --- Cancer --- Genetics --- Neoplasms --- Diseases --- Biology --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Oncology --- Medicine --- Health & Biological Sciences --- Genetic aspects --- Genetic aspects. --- Cancer genetics --- Medicine. --- Cancer research. --- Human genetics. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Human Genetics. --- Cancer genes --- Oncology . --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Cancer research
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