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Pruning --- Arboriculture --- Ornamental woody plants --- Sustainable development --- Morphogenesis --- plant growth substances --- Hormonal control --- Branching --- Plant habit --- Simulation models

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Veterinary drugs --- Growth factors --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides --- Veterinary materia medica --- Veterinary materia medica and pharmacy --- Veterinary pharmaceuticals --- Veterinary pharmacology --- Veterinary prescriptions --- Analysis.

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Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials on therapeutic compounds are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in research and treatment in this exciting field.

Angiogenesis Inhibitors. --- Neoplasms -- drug therapy. --- Neovascularization inhibitors. --- Neovascularization, Pathologic -- drug therapy. --- Neovascularization inhibitors --- Neoplasms --- Angiogenesis Inhibitors --- Drug Therapy --- Neovascularization, Pathologic --- Therapeutics --- Diseases --- Angiogenesis Modulating Agents --- Metaplasia --- Antineoplastic Agents --- Growth Inhibitors --- Therapeutic Uses --- Growth Substances --- Pathologic Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacologic Actions --- Physiological Effects of Drugs --- Pathological Conditions, Signs and Symptoms --- Chemical Actions and Uses --- Chemicals and Drugs --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Therapeutic use. --- Chemotherapy. --- Angiogenesis inhibitors --- Tumor angiogenesis inhibitors --- Medicine. --- Cancer research. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Tumors --- Haematology --- Internal medicine --- Blood --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antineoplastic agents --- Treatment

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The field of cancer biology and developmental therapeutics is continually evolving as new methodologies are developed and new targets are discovered. Although multiple therapeutics directly target the malignant cells these drugs rarely prevent recurrence of disease or the progression of metastasis. The complex biology of tumors presents challenges in designing treatments that will eliminate the malignant cells as well as the supporting network of vasculature and stroma that allows for the comparison of tumors to developing organs in embryos. In addition to blood vessels and malignant cells, tumors consist of fibroblasts, immune and inflammatory cells, and a myriad of proteins that comprise the extracellular matrix. Effective eradication of malignant disease requires therapeutic strategies that factor in targeting the tumor microenvironment. In the past decade, a new class of anticancer drugs has emerged that interferes with tumor angiogenesis; however the clinical benefit from treatment with the first generation antiangiogenic agents added to the standard of care is often modest. Thus, there remains a critical need to understand the tumor microenvironment and to develop anti-cancer therapies that address this aspect of malignant disease. The first edition of The Tumor Microenvironment is intended to give a current perspective on the role of the tumor microenvironment in malignant progression and detail strategies for novel therapies directed towards the cellular matrix. This book explores the many biological and physiological aspects of the tumor as a tissue and includes chapters on the variety of cells that influence tumor growth and spread as well as the cell-associated and soluble proteins that can promote invasion and metastasis. Several chapters describe endothelial cells and pericytes that form tumor vasculature. Insights into the role of progenitor and stem cells are included. The contribution of the supporting stroma is addressed in addition to cell-cell signaling and cell-matrix interactions. Additional chapters describe the influence of infiltrating cells of the immune system on tumor growth. The Tumor Microenvironment is the definitive text detailing cutting edge research by experts in the field and will be a valued resource in the study of this important area of cancer biology for many years to come.

Cancer cells -- Regulation. --- Cancer cells. --- Cancer invasiveness. --- Carcinogenesis. --- Tumors -- Metabolism. --- Carcinogenesis --- Tumors --- Cancer cells --- Chemistry, Pharmaceutical --- Angiogenesis Modulating Agents --- Cell Physiological Phenomena --- Medicine --- Diseases --- Growth Inhibitors --- Antineoplastic Agents --- Stem Cells --- Investigative Techniques --- Pharmacology --- Therapeutic Uses --- Growth Substances --- Phenomena and Processes --- Chemistry --- Cells --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health Occupations --- Neoplasms --- Angiogenesis Inhibitors --- Tumor Microenvironment --- Drug Discovery --- Pathology --- Neoplastic Stem Cells --- Biological Science Disciplines --- Anatomy --- Physiological Effects of Drugs --- Natural Science Disciplines --- Disciplines and Occupations --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Health & Biological Sciences --- Oncology --- Metabolism --- Growth --- Physiology, Pathological --- Tumors. --- Tumours --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Physiological effect --- Pathology, Cellular --- Cysts (Pathology) --- Oncology. --- Toxicology. --- Poisoning --- Poisons --- Toxicology

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The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.

Cellular signal transduction. --- Metastasis. --- Metastasis --- Cellular signal transduction --- Biochemical Processes --- Cell Physiological Processes --- Biological Science Disciplines --- Neoplastic Processes --- Natural Science Disciplines --- Biochemical Phenomena --- Neoplasms --- Cell Physiological Phenomena --- Pathologic Processes --- Chemical Processes --- Neoplasm Metastasis --- Signal Transduction --- Physiology --- Chemical Phenomena --- Disciplines and Occupations --- Diseases --- Phenomena and Processes --- Pathological Conditions, Signs and Symptoms --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Carcinogenesis --- Research. --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Cancer research --- Pathogenesis --- Dissemination --- Medicine. --- Cancer research. --- Molecular biology. --- Oncology. --- Proteins. --- Cytokines. --- Growth factors. --- Cell biology. --- Medicine & Public Health. --- Cancer Research. --- Molecular Medicine. --- Cytokines and Growth Factors. --- Receptors. --- Cell Biology. --- Pathology --- Genetic toxicology --- Cancer invasiveness --- Cancer of unknown primary origin --- Oncology  . --- Cell receptors. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Cellular immunity --- Immune response --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Tumors --- Regulation --- Health Workforce --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Systems biology