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Revealing the molecular basis of aging has been one of the most challenging aspects of medical science, and now the epigenetics of aging is in a Renaissance phase. This seminal work covers the fascinating role of epigenetics in aging, ranging from basic epigenetic processes of aging to epigenetic drugs that may intervene in allow aging and age-related diseases. Epigenetics of Aging presents in-depth analyses of DNA methylation, histone modifications, RNA alterations, and chromosomal defects that impact the aging process. It also includes detailed essays describing the impact of epigenetics on aging, the epigenetics of age-related diseases, and future directions and perspectives on the epigenetics of aging. With chapters authored by leading researchers in the field, this seminal book on the epigenetics of aging: -Ranges from basic science to clinical practice -Describes the importance of epigenetics in numerous diseases of aging such as cancer, Alzheimer’s disease, immune defects, and osteoporosis -Includes the role of epigenetics in premature aging diseases such as progeria -Highlights emerging aspects of epigenetics in aging, such as polycomb group genes and noncoding RNAs -Covers sirtuins, chromatin alterations, and the role of epigenetic drift in aging -Describes the impact of the environment and diet in modulating epigenetic processes during aging Epigenetics of Aging is the first book in this exponentially expanding field, and will be an indispensable source of information for those with interests in epigenetics and/or aging. This authoritative core textbook for advanced students or medical scientists and practitioners details the fascinating and revolutionary field of the epigenetics of aging and covers the most recent advances that impact the longevity of living organisms.

Aging -- Genetic aspects. --- Epigenesis. --- Genetic regulation. --- Aging --- Epigenesis --- Genetic regulation --- Biochemical Processes --- Gene Expression Regulation --- Methylation --- Biology --- Genetic Processes --- Biological Science Disciplines --- Growth and Development --- DNA Methylation --- Genetics --- Epigenesis, Genetic --- Physiology --- Alkylation --- Chemical Processes --- Genetic Phenomena --- Natural Science Disciplines --- Biochemical Phenomena --- Physiological Processes --- Disciplines and Occupations --- Phenomena and Processes --- Chemical Phenomena --- Physiological Phenomena --- Metabolism --- Metabolic Phenomena --- Medicine --- Human Anatomy & Physiology --- Pathology --- Health & Biological Sciences --- Genetic aspects --- Developmental biology. --- Genetic aspects. --- Development (Biology) --- Medicine. --- Cancer research. --- Human genetics. --- Pharmacology. --- Biomedicine. --- Human Genetics. --- Cancer Research. --- Pharmacology/Toxicology. --- Growth --- Ontogeny --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Heredity, Human --- Human biology --- Physical anthropology --- Toxicology --- Epigenesis, Genetic. --- genetics. --- x physiology. --- DNA Methylations --- Methylation, DNA --- Methylations, DNA --- Methyl CpG Binding Domain --- Genomic Imprinting --- Gene Silencing --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect

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From the early days when RNA interference was a strange artifact in worms to the 2006 Noble Prize received by Fire and Mello and the current clinical trials, the field of RNA interference has grown at a breakneck pace. In RNA Interference: From Biology to Clinical Applications, expert contributors provide an overview of the most current science and protocols that span the biological disciplines from detailed nucleic acid chemistry, to pharmacology, to the manipulation of signal transduction pathways. Divided into three distinct sections, this volume delves into the physiology of RNA interference, RNA interference in the laboratory and siRNA delivery, and preclinical and clinical issues associated with the use of RNAi-inducing agents as drugs in order to stimulate new questions and offer the tools necessary to start addressing those questions. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and inspiring, RNA Interference: From Biology to Clinical Applications aims to promote and motivate innovation by reviewing what has been done, providing details of how it has been done, and encouraging speculation on what the future may hold.

RNA editing --- Small interfering RNA --- Gene silencing --- RNA Interference --- Gene Silencing --- Epigenesis, Genetic --- Gene Expression Regulation --- Genetic Processes --- Genetic Phenomena --- Phenomena and Processes --- Microbiology & Immunology --- Animal Biochemistry --- Genetics --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Gene Silencing. --- RNA Interference. --- RNA editing. --- Gene silencing. --- ARN --- Inactivation génétique --- Edition --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Gene Inactivation --- Inactivation, Gene --- Silencing, Gene --- Co-Suppression --- Cosuppression --- Posttranscriptional Gene Silencing --- RNA Silencing --- RNAi --- Gene Silencing, Post-Transcriptional --- Post-Transcriptional Gene Silencing --- Co Suppression --- Gene Silencing, Post Transcriptional --- Gene Silencing, Posttranscriptional --- Gene Silencings, Posttranscriptional --- Interference, RNA --- Post Transcriptional Gene Silencing --- Post-Transcriptional Gene Silencings --- Silencing, Post-Transcriptional Gene --- Gene inactivation --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- Scan RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- Editing, RNA --- Messenger RNA editing --- mRNA editing --- Immunology. --- Medical laboratories. --- Laboratory Medicine. --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Immunobiology --- Life sciences --- Serology --- Medicine --- Biomedical Research. --- Biological research --- Biomedical research --- Health Workforce --- Research.