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Dog diseases --- Cat diseases --- Digestive system diseases --- Gastrointestinal diseases --- Liver diseases --- Pancreatic diseases --- Biliary tract diseases --- veterinary --- diagnosis --- therapy --- diet therapy

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Liver --- Biliary tract --- Pancreas --- Biliary Tract Diseases. --- Liver Diseases. --- Pancreatic Diseases. --- Diseases --- Diseases. --- Bilious diseases and biliousness --- Biliary tree --- Digestive organs --- Endocrine glands --- Exocrine glands --- Bile --- Abdomen --- Disease, Pancreatic --- Diseases, Pancreatic --- Pancreatic Disease --- Liver Dysfunction --- Disease, Liver --- Diseases, Liver --- Dysfunction, Liver --- Dysfunctions, Liver --- Liver Disease --- Liver Dysfunctions --- Biliary Tract Disease --- Disease, Biliary Tract --- Diseases, Biliary Tract --- Tract Disease, Biliary --- Tract Diseases, Biliary --- Surgery - General and By Type

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Over the past two decades, tremendous advances have been made in the field of cancer drug discovery, particularly in the area of molecular and genetic models and technologies, many of which have been or are beginning to be applied to the drug discovery process for pancreatic cancer. Drug Discovery in Pancreatic Cancer: Models and Techniques offers the latest development in the application of those models and technologies in pancreatic cancer. The authors include experts in their perspective field of research including basic scientists as well as clinicians who work on the frontline in the war against pancreatic cancer and have first-hand experience employing these cutting-edge tools and techniques. The book progresses logically from modeling systems to genomic profiling, proteomic analysis, and pharmacodynamic assays. It features: • Up-to-date survey of many cell lines and animal models of pancreatic cancer and their applications in drug discovery. • Application of fluorescent mouse models in pancreatic cancer drug discovery. • Utility of cutting-edge genomics, proteomics, epigenomics, and glycomics methodologies for molecular target identification and validation. • Discussion of microRNA profiling and high throughput RNAi screening for pancreatic cancer drug discovery. • Broad screening technologies for proteins and nucleic acids using tissue microarrays and CGH arrays. • Development of pharmacodynamic endpoint assays for targeted therapeutics. Comprehensive and practical Drug Discovery in Pancreatic Cancer: Models and Techniques offers both basic and clinical scientists who are interested in pancreatic cancer an up-to-date review and assessment of models and technologies being applied in drug discovery for pancreatic cancer. The true premise of this book is to provide a guide for drug discovery and evaluation, with consideration of various modeling systems and the methods for screening/profiling responses to these compounds. It is the Editors intent to stimulate new thought in this area of research as a means of generating much improved drug efficacy for greater survival and quality of life for patients battling pancreatic cancer.

Cancer -- Molecular aspects. --- Pancrea -- Cancer -- Chemotherapy. --- Pancrea --- Cancer --- Investigative Techniques --- Endocrine Gland Neoplasms --- Pancreatic Diseases --- Chemistry, Pharmaceutical --- Digestive System Neoplasms --- Models, Biological --- Models, Genetic --- Drug Discovery --- Pancreatic Neoplasms --- Digestive System Diseases --- Neoplasms by Site --- Endocrine System Diseases --- Pharmacology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry --- Models, Theoretical --- Diseases --- Natural Science Disciplines --- Biological Science Disciplines --- Neoplasms --- Disciplines and Occupations --- Medicine --- Oncology --- Health & Biological Sciences --- Chemotherapy --- Molecular aspects --- Pancreas --- Chemotherapy. --- Molecular aspects. --- Medicine. --- Cancer research. --- Pharmacology. --- Oncology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Digestive organs --- Endocrine glands --- Exocrine glands --- Oncology  . --- Toxicology. --- Chemicals --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Drugs --- Pharmacy --- Cancer research --- Physiological effect

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The human pancreas has vital roles in the regulation of glucose homeostasis and digestion and its dysfunction leads to pancreatic disease as diabetes and pancreatitis. Recent researches have highlighted the novel roles of a local renin-angiotensin system (RAS) in the pancreas and its clinical relevances; its inapprporiate activation leads to pancreatic endocrine and exocrine disease, notably type 2 diabetes. As such, manipulation of the overactive RAS may improve pancreatic islet cell function, cell mass and insulin sensitivity, as well as enhancing the growth and differentiation of pancreatic stem cells. Blockade of the RAS may be protective against pancreatitis and pancreatic cancer. The research outcome of current progress on the RAS in the pancreas should provide an alternative approach to preventing and treating, as well as curing pancreatic disease. This book discusses the progress of research on the renin-angiotensin system in the pancreas from the science to the bedside, providing a timely review of this expanding area. It consists of ten interrelated chapters covering subjects as: – Structure, physiology and disease of the pancreas – Biochemistry and physiology of the pancreatic renin-angiotensin system – RAS in diabetes, stem cells and pancreatitis This book is of special value to basic and clinical scientists, clinicians, graduate students, as well as novices in this field.  .

Pancreas. --- Renin-angiotensin system. --- Renin-angiotensin system --- Pancreas --- Research --- Digestive System --- Digestive System Diseases --- Hemodynamics --- Metabolism --- Diseases --- Science --- Anatomy --- Cardiovascular Physiological Processes --- Metabolic Phenomena --- Biomedical Research --- Renin-Angiotensin System --- Pancreatic Diseases --- Natural Science Disciplines --- Cardiovascular Physiological Phenomena --- Phenomena and Processes --- Disciplines and Occupations --- Circulatory and Respiratory Physiological Phenomena --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Angiotensins --- Renin --- Kidneys --- Physiology. --- Pathophysiology. --- Angiotensin --- Medicine. --- Human physiology. --- Diabetes. --- Gastroenterology. --- Biomedicine. --- Biomedicine general. --- Human Physiology. --- Internal medicine --- Digestive organs --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Aspartic proteinases --- Juxtaglomerular apparatus --- Neuropeptides --- Oligopeptides --- Peptide hormones --- Health Workforce --- Gastroenterology . --- Biomedicine, general.