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The book consists of 31 chapters, divided into six parts. Each chapter is written by one or several experts in the corresponding area. The scope of the book varies from the DNA damage response and DNA repair mechanisms to evolutionary aspects of DNA repair, providing a snapshot of current understanding of the DNA repair processes. A collection of articles presented by active and laboratory-based investigators provides a clear understanding of the recent advances in the field of DNA repair.

DNA repair. --- Deoxyribonucleic acid repair --- Repair, DNA --- Repair mechanisms in DNA --- Biochemical genetics --- Antimutagens --- Medical genetics

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The DNA of mammalian cells is constantly under assault from both endogenous and exogenous sources.  Ionizing radiation is one of the most important sources of genomic injury because of its ability to inflict substantial cellular damage that is both therapeutic as well as mutagenic.  Mammalian cells have evolved an impressive array of DNA damage response mechanisms that are called upon to respond to and repair radiation-induced DNA injury that allow cells to survive with DNA fidelity intact.  Contemporary oncologic research and patient management demand a thorough understanding of these DNA damage response processes as well as some of the important environmental conditions like hypoxia in which cells exist such that strategies that subvert these survival processes can be considered and exploited for therapeutic gain. Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins.  The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury.   The authors have done a wonderful job in providing meaningful reviews, with appropriate detail and scope for both the well informed reader as well as the novice looking for new information.  Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

DNA damage -- Radiation effects. --- DNA damage. --- DNA repair -- Radiation effects. --- Neoplasms -- Radiotherapy. --- Signal transduction -- Radiation effects. --- DNA damage --- Genetic Processes --- Biochemical Processes --- Radiation --- Therapeutics --- Diseases --- Cell Physiological Processes --- Chemical Processes --- Cell Physiological Phenomena --- Genetic Phenomena --- Biochemical Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Electromagnetic Phenomena --- Physical Phenomena --- Chemical Phenomena --- Phenomena and Processes --- DNA Repair --- DNA Damage --- Neoplasms --- Signal Transduction --- Radiation Effects --- Radiotherapy --- Biology --- Medicine --- Health & Biological Sciences --- Genetics --- Oncology --- Cancer --- Radiotherapy. --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Treatment --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect