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Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.
Enzyme kinetics --- Pharmacological Phenomena --- Metabolic Phenomena --- Enzymes and Coenzymes --- Computing Methodologies --- Kinetics --- Investigative Techniques --- Phenomena and Processes --- Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemicals and Drugs --- Information Science --- Biochemical Phenomena --- Chemical Phenomena --- Mathematical Computing --- Enzymes --- Pharmacokinetics --- Models, Theoretical --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Animal Biochemistry --- Biology - General --- Mathematical models --- Data processing --- Mathematical models. --- Data processing. --- Dynamics, Enzyme --- Enzyme dynamics --- Kinetics, Enzyme --- Life sciences. --- Bioinformatics. --- Biomathematics. --- Life Sciences. --- Computational Biology/Bioinformatics. --- Mathematical and Computational Biology. --- Chemical kinetics --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Mathematics
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