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Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest.  In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response. This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).

Bones -- Cancer -- Treatment. --- Bones -- Cancer. --- Protease inhibitors --- Enzyme Inhibitors --- Proteins --- Medicine --- Pathologic Processes --- Receptors, Cell Surface --- Hydrolases --- Enzymes --- Amino Acids, Peptides, and Proteins --- Molecular Mechanisms of Pharmacological Action --- Pathological Conditions, Signs and Symptoms --- Health Occupations --- Membrane Proteins --- Enzymes and Coenzymes --- Pharmacologic Actions --- Disciplines and Occupations --- Chemicals and Drugs --- Diseases --- Chemical Actions and Uses --- Peptide Hydrolases --- Receptors, Proteinase-Activated --- Protease Inhibitors --- Pathology --- Carrier Proteins --- Inflammation --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Therapeutic use --- Proteolytic enzymes. --- Peptide hydrolases --- Proteases --- Medicine. --- Immunology. --- Infectious diseases. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Infectious Diseases. --- Cytology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Immunobiology --- Life sciences --- Serology

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Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.

Antineoplastic agents. --- Multiple myeloma -- Chemotherapy. --- Multiple myeloma -- Treatment. --- Multiple myeloma --- Antineoplastic agents --- Hemostatic Disorders --- Boron Compounds --- Heterocyclic Compounds, 1-Ring --- Paraproteinemias --- Acids, Noncarboxylic --- Lymphoproliferative Disorders --- Peptide Hydrolases --- Therapeutics --- Therapeutic Uses --- Neoplasms, Plasma Cell --- Enzyme Inhibitors --- Multienzyme Complexes --- Enzymes --- Hydrolases --- Blood Protein Disorders --- Organic Chemicals --- Heterocyclic Compounds --- Acids --- Immunoproliferative Disorders --- Pharmacologic Actions --- Hemorrhagic Disorders --- Multiprotein Complexes --- Vascular Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Inorganic Chemicals --- Molecular Mechanisms of Pharmacological Action --- Neoplasms by Histologic Type --- Boronic Acids --- Multiple Myeloma --- Antineoplastic Agents --- Drug Therapy --- Proteasome Endopeptidase Complex --- Protease Inhibitors --- Pyrazines --- Chemicals and Drugs --- Immune System Diseases --- Hematologic Diseases --- Macromolecular Substances --- Chemical Actions and Uses --- Cardiovascular Diseases --- Neoplasms --- Enzymes and Coenzymes --- Diseases --- Hemic and Lymphatic Diseases --- Medicine --- Health & Biological Sciences --- Oncology --- Treatment --- Chemotherapy --- Treatment. --- Chemotherapy. --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Kahler's disease --- Plasma cell myeloma --- Medicine. --- Cancer research. --- Pharmacology. --- Oncology. --- Apoptosis. --- Medicine & Public Health. --- Cancer Research. --- Pharmacology/Toxicology. --- Drugs --- Cancer --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Tumors --- Oncology  . --- Toxicology. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Cell death --- Drug effects --- Medical pharmacology --- Medical sciences --- Pharmacy --- Cancer research --- Physiological effect