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Gastric cancer is one of the most common tumors worldwide. It has a heterogeneous milieu, where the genetic background, tumor immunology, oxidative stress, and microbial infections are key players in the multiple stages of tumorigenesis. These diverse factors are linked to the prognosis of the gastric cancer and the survival of gastric cancer patients. This book is appropriate for scientists and students in the field of oncology, gastroenterology, molecular biology, immunology, cell biology, biology, biochemistry, and pathology. This authoritative text carefully explains the fundamentals, providing a general overview of the principles followed by more detailed explanations of these recent topics efficiently. The topics presented herein contain the most recent knowledge in gastric cancer concerning the oncogenic signaling, genetic instability, the epigenetic aspect, molecular features and their clinical implications, miRNAs, integrin and E-cadherin, carbohydrate-associated-transferases, free radicals, immune cell responses, mucins, Helicobacter-pylori, neoadjuvant and adjuvant therapy, prophylactic strategy for peritoneal recurrence, and hepatic metastasis.

Stomach --- Cancer. --- Oncology

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This book is a comprehensive overview of invited contributions on Helicobacter pylori infection in gastritis and gastric carcinogenesis. The first part of the book covers topics related to the pathophysiology of gastric mucosal defense system and gastritis including the gastroprotective function of the mucus, the capsaicin-sensitive afferent nerves and the oxidative stress pathway involved in inflammation, apoptosis and autophagy in H. pylori related gastritis. The next chapters deal with molecular pathogenesis and treatment, which consider the role of neuroendocrine cells in gastric disease, DNA methylation in H. pylori infection, the role of antioxidants and phytotherapy in gastric disease. The final part presents the effects of cancer risk factors associated with H. pylori infection. These chapters discuss the serum pepsinogen test, K-ras mutations, cell kinetics, and H. pylori lipopolysaccharide, as well as the roles of several bacterial genes (cagA, cagT, vacA and dupA) as virulence factors in gastric cancer, and the gastrokine-1 protein in cancer progression.

Gastritis. --- Stomach --- Gastroenteritis --- Inflammation --- Diseases --- Hepatology

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endoscopy --- gastroenterology & hepatology --- diagnostic imaging --- therapeutic endoscopy --- Enteroscopy --- Gastroscopy --- Endoscopy, Digestive System. --- Enteroscopy. --- Gastroscopy. --- Intestinal endoscopy --- Digestive System Endoscopic Surgery --- Endoscopic, Digestive System, Surgery --- Endoscopic, Digestive System, Surgical Procedure --- Procedure, Digestive System, Endoscopic, Surgical --- Procedure, Endoscopic, Digestive System, Surgical --- Procedures, Digestive System, Endoscopic, Surgical --- Procedures, Endoscopic, Digestive System, Surgical --- Surgery, Digestive System Endoscopic --- Surgery, Endoscopic, Digestive System --- Surgical Procedure, Endoscopic, Digestive System --- Digestive System Endoscopic Surgical Procedures --- Esophagogastroduodenoscopy --- Surgical Procedures, Endoscopic, Digestive System --- Digestive System Endoscopies --- Digestive System Endoscopy --- Endoscopies, Digestive System --- Esophagogastroduodenoscopies --- Gastroscope and gastroscopy --- Endoscopy --- Intestines --- Stomach --- Examination --- Gastroenterology --- Endoscopy, Digestive System