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Kanker --- Cancer in children --- Onderzoek --- België

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This is the first book to be devoted exclusively to rare tumors in children and adolescents, and its aim is to provide up-to-date information on their diagnosis and clinical management. The opening section of the book addresses general issues including epidemiology, risk factors/etiology, biology and genetics, prevention, early detection, and screening. It also discusses solutions to assist in the management of rare tumors, such as international networking and internet platforms, thus providing the reader with access to the developing clinical network for rare tumors in children. In the second section, specific malignancies are described, with practical guidance on diagnostic workup, multimodal therapy, survival outcome, follow-up, and adverse effects. These chapters are organized by site according to the clinician’s approach to the patient. Each chapter includes an introduction to the differential diagnostic assessment of tumors at the site in question, encompassing both frequent and rare tumor types. This approach should enable the clinician to take rare entities into account during the diagnostic assessment, so that the initial diagnostic steps are performed optimally. Each chapter goes on to provide detailed therapeutic guidelines for specific rare tumors. The authors are a multidisciplinary group of specialists who have dedicated themselves to this group of tumors. This well-illustrated book will prove an invaluable source of information for all pediatricians and oncologists faced with the often difficult task of diagnosing and treating rare tumors in the pediatric age group.

Tumors in adolescence. --- Tumors in children. --- Cancer in children --- Diseases --- Age Groups --- Disease Attributes --- Medicine --- Pathologic Processes --- Health Occupations --- Persons --- Pathological Conditions, Signs and Symptoms --- Named Groups --- Disciplines and Occupations --- Pathology --- Rare Diseases --- Neoplasms --- Adolescent --- Child --- Health & Biological Sciences --- Oncology --- Tumors in children --- Cancer in children. --- Diagnosis. --- Childhood cancer --- Pediatric cancer --- Pediatric oncology --- Medicine. --- Oncology. --- Pediatrics. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Paediatrics --- Pediatric medicine --- Children --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Excision --- Treatment --- Health and hygiene --- Oncology  . --- Cancer Therapy. --- Treatment. --- Cancer therapy --- Cancer treatment --- Therapy

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Brain tumors are the most common solid tumor of childhood as well as the leading cause of cancer-related mortality in children. This third volume of the Springer series discussing pediatric cancer focuses on diagnosing, treating, and assessing the future course of malignant brain neoplasms in children. In addition to a general introduction to the principals involved, the material includes vital research in molecular genetics, a major contribution to the molecular characterization of solid tumors, which will define new biomarkers of the disease and identify molecular pathways. Now it has become possible to achieve the goal of targeting new, more effective therapies to minimize the tragedy faced by children. This research features the application of molecular genetics in combating atypical teratoid/rhabdoid tumor (AT/RT), a highly aggressive embryonal CNS tumor that is among the most common malignant neoplasms in children, with a peak occurrence in infants younger than three years old. Contributors also examine the reasons for the common misdiagnosis of AT/RT tumors as other types of CNS tumors. They help resolve this issue by indicating the details of an abnormality in the genetics of AT/RT, which is unique to AT/RT type. The INII gene on chromosome 22q11 is involved in the AT/RT. The presence of this gene and the SMARCB1 is discussed. In addition to discussing these important topics, the volume includes presentations of present and future therapies. The volume also explains AT/RT’s dissemination to the cerebral fluid, the molecular mechanisms underlying the progression of medulloblastoma, and the importance of gamma knife radiosurgery during multimodality management of medulloblastoma/PNET tumors. Other topics discussed include using magnetic resonance imaging for diagnosing retinoblastoma, and mapping the effects of radiotherapy in low-grade glioma in children. Information on alterations in cell-cycle regulators that are influenced by tumor suppressor genes and oncogenes is detailed. Contributors provide recommendations concerning non-narcotic analgesic routines for children recovering from cranial and spinal surgery. The practical knowledge of frontier-expanding research presented leads this authoritative volume to be a compelling addition to the literature.

Cancer in children. --- Neoplasms by Histologic Type --- Age Groups --- Neoplasms --- Persons --- Diseases --- Named Groups --- Neoplasms, Germ Cell and Embryonal --- Child --- Neoplasms, Complex and Mixed --- Medicine --- Health & Biological Sciences --- Oncology --- Childhood cancer --- Pediatric cancer --- Medicine. --- Cancer research. --- Oncology. --- Pediatrics. --- Primary care (Medicine). --- Pediatric surgery. --- Biomedicine. --- Cancer Research. --- Primary Care Medicine. --- Pediatric Surgery. --- Tumors in children --- Emergency medicine. --- Oncology  . --- Surgery. --- Surgery, Primitive --- Tumors --- Medicine, Emergency --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Paediatrics --- Pediatric medicine --- Children --- Health and hygiene --- Pediatric surgery --- Surgery, Pediatric --- Primary medical care --- Medical care --- Cancer research --- Treatment

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Pediatric Cancer: Teratoid/Rhabdoid, Brain Tumors, and Glioma   ·                  Epilepsy prognosis and treatment ·                  Symptoms of tumors in children ·                  Diagnostic imaging technology   This second volume in the Pediatric Cancer series edited by Professor M.A. Hayat presents a general introduction to the principles of diagnosis and treatment of children with brain tumors.   *Cancer is the leading cause of death by disease among U.S. children between infancy and age 15. Approximately 11,210 new cases of pediatric cancer are expected to be diagnosed in children 0–14 years of age in 2011.   A complete resource for researchers in the symptoms of tumors in children, epilepsy prognosis and treatment and diagnostic imaging technology, this volume presents and discusses:   ·        Molecular characterization of solid tumors, ·        The role of molecular pathways providing putative targets for new therapies. ·        High resolution magic angle spinning NMR spectroscopy, to determine metabolic profiles for small pieces of intact tissue and whole cells in culture, ·        The differences between adult and pediatric brain tumors, ·        The role of tumor suppressor genes and oncogenes in the development and progression of human malignancies, ·        Various neuroradiological imaging modalities in children with leukemia,   This volume also examines in detail the results of clinical trials using radiotherapy in pediatric brain tumors, such as medulloblastoma, ependymoma, craniopharyngioma, low-grade glioma, high-grade glioma, brainstem glioma, and germ cell tumors.   Aimed at researchers and medical oncologists, Pediatric Cancer volume 2, will also be of interest to medical technicians, pharmaceutical companies and of course, medical libraries.   Professor M.A. Hayat is Distinguished Professor at the Department of Biology, Kean University NJ, USA.     *National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services http://www.cancer.gov/aboutnci/servingpeople/cancer-statistics/snapshots  .

Cancer in children. --- Age Groups --- Neoplasms, Neuroepithelial --- Central Nervous System Neoplasms --- Neoplasms, Complex and Mixed --- Neoplasms, Germ Cell and Embryonal --- Brain Diseases --- Neuroectodermal Tumors --- Persons --- Nervous System Neoplasms --- Neoplasms, Glandular and Epithelial --- Central Nervous System Diseases --- Neoplasms by Histologic Type --- Neoplasms --- Named Groups --- Nervous System Diseases --- Neoplasms, Nerve Tissue --- Neoplasms by Site --- Diseases --- Adolescent --- Child --- Brain Neoplasms --- Glioma --- Teratoma --- Rhabdoid Tumor --- Infant --- Medicine --- Health & Biological Sciences --- Oncology --- Teratocarcinoma. --- Brain --- Gliomas. --- Tumors. --- Teratoid carcinoma --- Medicine. --- Cancer research. --- Radiology. --- Oncology. --- Pediatric surgery. --- Surgical oncology. --- Biomedicine. --- Cancer Research. --- Pediatric Surgery. --- Imaging / Radiology. --- Surgical Oncology. --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Pediatric surgery --- Surgery, Pediatric --- Children --- Tumors --- Radiological physics --- Physics --- Radiation --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Excision --- Treatment --- Nervous system --- Surgery. --- Radiology, Medical. --- Oncology  . --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Surgery, Primitive