Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Trypsin. --- Trypsin inhibitors. --- Alkali proteinase --- Trypsase --- Digestive enzymes --- Pancreas --- Serine proteinases --- Antagonists, Trypsin --- Antitrypsin --- Inhibitors, Trypsin --- Trypsin --- Trypsin antagonists --- Enzyme inhibitors --- Secretions --- Antagonists

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Organophosphate compounds, first synthesized in the 1800's, have been used for insecticides, pesticides, and in war and terrorism, such as the 1995 Tokyo subway poisoning. This book provides an in-depth examination of the effects of organophosphates and nerve agents and offers therapeutic and prophylactic countermeasures. Beginning with an overview of milestones in the use of toxic chemicals and chemical warfare agents, the formulae and toxicities of compounds are given, along with tables outlining animal toxicities. Data on various compounds' inhibitions and subsequent accumulations are...

Nerve agents -- Poisoning. --- Organophosphate compounds. --- Organophosphate. --- Enzyme Inhibitors --- Poisons --- Cholinergic Agents --- Anatomy --- Protective Agents --- Enzyme Reactivators --- Weapons of Mass Destruction --- Weapons --- Specialty Uses of Chemicals --- Noxae --- Physiological Effects of Drugs --- Neurotransmitter Agents --- Molecular Mechanisms of Pharmacological Action --- Manufactured Materials --- Pharmacologic Actions --- Chemical Actions and Uses --- Toxic Actions --- Technology, Industry, and Agriculture --- Chemicals and Drugs --- Technology, Industry, Agriculture --- Antidotes --- Cholinesterase Inhibitors --- Chemical Warfare Agents --- Cholinesterase Reactivators --- Nervous System --- Public Health --- Health & Biological Sciences --- Toxicology & Public Health --- Nerve gases. --- Poisons. --- Chemical agents (Munitions) --- Chemical warfare agents --- Chemical weapons --- Chemicals --- Poisonous chemicals --- Poisonous substances --- Toxic chemicals --- Toxic substances --- Toxicants --- Toxics --- Bioactive compounds --- Hazardous substances --- Toxicology --- Nerve agents (Munitions) --- Nerve gas --- Cholinesterase inhibitors --- Gases, Asphyxiating and poisonous --- Neurotoxic agents --- Organophosphorus compounds

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

DNA topoisomerases are present in all living organisms and are essential to maintaining the helical structure of DNA. They are highly relevant for cancer because a number of anti-cancer drugs selectively target two of the human enzymes, DNA topoisomerases I and II. Those drugs convert topoisomerases into cellular poisons by trapping the enzymes as they cleave DNA. The book starts out with a detailed outline of the phyllogeny of the different topoisomerases, continues with recent studies on the crystal structures of the human topoisomerases, and their biochemistry. The following section reviews the chemical biology of the topoisomerase inhibitors used in cancer chemotherapy and the implication of topoisomerases in generating recombinations and DNA damage. The third section summarizes the current use of the various topoisomerase inhibitors in cancer chemotherapy. And finally, the last section includes several chapters describing the DNA repair pathways for topoisomerase-induced DNA damage. This book is intended for students and faculty but also for health care professionals who wish to have a self-contained and up-to-date information on topoisomerases. Chapters have been written by leaders and world reknowned experts in the topoisomerase field.

Cancer -- Chemotherapy. --- DNA topoisomerases -- Inhibitors. --- DNA topoisomerase I --- DNA topoisomerase II --- Cancer --- Natural Science Disciplines --- Therapeutics --- Topoisomerase Inhibitors --- DNA Topoisomerases --- Biology --- Diseases --- Therapeutic Uses --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacologic Actions --- Isomerases --- Enzyme Inhibitors --- Biological Science Disciplines --- Disciplines and Occupations --- Enzymes --- Molecular Mechanisms of Pharmacological Action --- Chemical Actions and Uses --- Enzymes and Coenzymes --- Chemicals and Drugs --- Chemistry --- Neoplasms --- Genetics --- Drug Therapy --- Antineoplastic Agents --- DNA Topoisomerases, Type I --- Topoisomerase I Inhibitors --- Medicine --- Health & Biological Sciences --- Oncology --- Chemotherapy --- DNA topoisomerases. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Topoisomerases, DNA --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Tumors --- Oncology. --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Toxicology