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Studies of human movement have proliferated in recent years. This greatly expanded and thoroughly updated reference surveys the literature on the corticospinal control of spinal cord circuits in human subjects, showing how different circuits can be studied, their role in normal movement and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks and changes in patients with CNS lesions. Each chapter concludes with a helpful résumé that can be used independently of the main text to provide practical guidance for clinical studies. The final four chapters bring together the changes in transmission in spinal and corticospinal pathways during movement and how they contribute to the desired movement. This book is essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.

Spinal cord --- Neural circuitry. --- Circuitry, Neural --- Circuits, Neural --- Nerve net --- Nerve network --- Neural circuits --- Neurocircuitry --- Neuronal circuitry --- Electrophysiology --- Nervous system --- Neural networks (Neurobiology) --- Reflexes --- Central nervous system --- Physiology. --- Spinal cord. --- Motor ability. --- Movement disorders. --- Diseases. --- Dyskinesia --- Dyskinesias --- Motor disorders --- Disabilities --- Agility --- Coordination, Muscular --- Dexterity --- Manual dexterity --- Manual skill --- Motor control (Physiology) --- Motor dexterity --- Motor skill --- Motor skills --- Muscular coordination --- Skills, Motor --- Ability --- Movement, Psychology of --- Kinesiology --- Mechanical ability --- Diseases

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Neuronal phase response curves (PRCs) summarize the relationship between the timing of inputs within a neuron’s spike cycle and the consequent shifts in output spike timing.  The form of a neuron’s PRC reflects its mechanism of spike initiation or excitability as well as other influences of membrane conductances on synaptic integration.  PRCs are efficient encapsulations of the input-output processing of individual neurons to single perturbations and are powerful devices for the prediction and interpretation of patterned neuronal network activity including synchronization phenomena in connected networks or populations receiving shared input.  Thus, application of phase response analysis to neural systems targets the interface of neural computation at the cellular and network levels, one of the most critical and expansive gaps in our understanding of the brain.  This volume surveys the diversity of applications of phase response analysis by many of the prominent theoreticians and experimentalists in the Computational Neurosciences.  Readers will find a thorough introduction to the foundational concepts underlying phase response analysis, advanced techniques for accurate estimation of neuronal PRCs, and impactful illustrations of both the cellular underpinnings of the phase response properties of neurons and the power of phase response analysis to explain network behavior.  Throughout the book, the authors use phase response analysis to elucidate a number of neural systems that are current foci of exciting research in the Computational Neurosciences and are at the forefront of our advancing grasp of the complex mechanisms of brain function and dysfunction.

Computational neuroscience. --- Computational neuroscience --- Neurobiology --- Intercellular Junctions --- Electrophysiological Processes --- Models, Biological --- Signal Transduction --- Biological Science Disciplines --- Nervous System --- Cells --- Nervous System Physiological Processes --- Cell Physiological Processes --- Anatomy --- Natural Science Disciplines --- Physiological Processes --- Cell Membrane Structures --- Nervous System Physiological Phenomena --- Biochemical Processes --- Models, Theoretical --- Electrophysiological Phenomena --- Physiological Phenomena --- Cell Physiological Phenomena --- Disciplines and Occupations --- Musculoskeletal and Neural Physiological Phenomena --- Investigative Techniques --- Cell Membrane --- Biochemical Phenomena --- Chemical Processes --- Chemical Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Phenomena and Processes --- Cellular Structures --- Synaptic Transmission --- Synapses --- Nerve Net --- Neurons --- Physiology --- Models, Neurological --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Neuroscience --- Neurology --- Mathematical models --- Computational neurosciences --- Medicine. --- Neurosciences. --- Neurology. --- Biomedicine. --- Computational biology --- Neurosciences --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Medical sciences --- Diseases --- Neurology .