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Following a transmural myocardial infarctions (MI), the resultant dilated, aneurismal ventricle can make patient management difficult in those ineligible for cardiac transplantation. This mechanical complication leads to refractory heart failure and continues to be a persisting problem for clinical management in both the developed and developing countries of the world. It continues to exist despite improvements in door to needle time for primary coronary interventions. There has been increased interest in potential surgical techniques involved in the palliation of ventricular pathology post-MI. The process of cardiac remodeling has been studied extensively, and recent surgical techniques for ventricular restoration have proven late adverse remodeling. Surgical techniques for ventricular restoration of these adversely remodeled ventricles aimed at restoring a near normal ventricular geometry consequently have a continuing role in the management of this difficult subset of patients. Ventricular Geometry in Post-Myocardial Infarction Aneurysms: Implications for Surgical Ventricular Restoration provides cardiac surgeons and cardiologists a definitive perspective of optimal surgical ventricular restoration in patients with advanced heart failure due to large ventricular aneurysms following transmural myocardial infarctions. The authors review normal and abnormal cardiac anatomy following post myocardial infarction and physiology, with focus on the evolution of surgical techniques aimed at establishing an ellipsoid ventricular shape, resulting in near-normal physiological hemodynamics evident at long term.
Cardiovascular Diseases -- surgery. --- Cardiovascular Surgical Procedures. --- Cardiovascular system -- Diseases -- Surgery. --- Chest -- Surgery. --- Heart -- Surgery. --- Heart --- Ventricular Dysfunction --- Ventricular Function --- Myocardial Ischemia --- Pathological Conditions, Anatomical --- Heart Diseases --- Cardiovascular Physiological Processes --- Cardiovascular System --- Vascular Diseases --- Pathological Conditions, Signs and Symptoms --- Cardiovascular Physiological Phenomena --- Cardiovascular Diseases --- Anatomy --- Diseases --- Circulatory and Respiratory Physiological Phenomena --- Phenomena and Processes --- Myocardial Infarction --- Heart Ventricles --- Ventricular Dysfunction, Left --- Ventricular Remodeling --- Ventricular Function, Left --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Coronary heart disease --- Ventricular aneurysms. --- Surgery. --- Left ventricle --- Pathophysiology. --- Medicine. --- Cardiology. --- Cardiac surgery. --- Medicine & Public Health. --- Cardiac Surgery. --- Medicine/Public Health, general. --- Cardiopulmonary system --- Cardiovascular system --- Chest --- Aneurysms --- Surgery --- Internal medicine --- Cardiac surgery --- Open-heart surgery --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce
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This volume of the Subcellular Biochemistry series is devoted to the aggregation and fibrillogenesis of the amyloid-forming peptides and proteins, including emphasis on oligomer formation as well as fibril formation. The diverse topics included here are presented within 22 chapters, covering many of the relevant topics from both a basic science and clinical perspective. The authorship of these chapters is thoroughly international, with authoritative contributions from active researchers. Fundamental structural and cellular studies using many different technical approaches are presented, leading through to clinical and therapeutic aspects of the amyloid diseases, considered from both pharmaceutical and natural product view points. It is hoped that this book will be of use to both biomedical scientists and clinicians wishing to keep abreast of this rapidly advancing field, of direct importance to the understanding of cerebral neurodegenerative disease and systemic amyloid disease.
Amyloid. --- Amyloidosis -- Diagnosis. --- Amyloidosis -- Treatment. --- Amyloidosis. --- Amyloid beta-protein --- Aggregation (Chemistry) --- Amyloidosis --- Proteins --- Proteostasis Deficiencies --- Biophysical Processes --- Multiprotein Complexes --- Pathological Conditions, Anatomical --- Biochemical Processes --- Cell Movement --- Physical Processes --- Metabolic Diseases --- Cell Physiological Processes --- Amino Acids, Peptides, and Proteins --- Macromolecular Substances --- Biochemical Phenomena --- Chemical Processes --- Biophysical Phenomena --- Pathological Conditions, Signs and Symptoms --- Nutritional and Metabolic Diseases --- Diseases --- Chemical Phenomena --- Physical Phenomena --- Chemicals and Drugs --- Cell Physiological Phenomena --- Phenomena and Processes --- Protein Folding --- Plaque, Amyloid --- Amyloid --- Cell Aggregation --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Metabolism --- Disorders. --- Protein metabolism disorders --- Amyloid degeneration --- Medicine. --- Entomology. --- Biomedicine. --- Biomedicine general. --- Medicine/Public Health, general. --- Lymphoproliferative disorders --- Disorders --- Insects --- Zoology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general. --- Medicine --- Biology --- Invertebrates. --- Medical sciences. --- Biomedical Research. --- Invertebrate Zoology. --- Health Sciences. --- Research. --- Invertebrata --- Animals --- Biological research --- Biomedical research --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical
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