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2014 (65)

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Book
Experiments in the purification and characterization of enzymes : a laboratory manual
Authors: ---
ISBN: 0124095933 0124095445 9780124095441 Year: 2014 Publisher: Amsterdam : Elsevier,

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"Experiments in the Purification and Characterization of Enzymes: A Laboratory Manual provides students with a working knowledge of the fundamental and advanced techniques of experimental biochemistry. Included are instructions and experiments that involve purification and characterization of enzymes from various source materials, giving students excellent experience in kinetics analysis and data analysis. Additionally, this lab manual covers how to evaluate and effectively use scientific data. By focusing on the relationship between structure and function in enzymes, Experiments in the Purification and Characterization of Enzymes: A Laboratory Manual provides a strong research foundation for students enrolled in a biochemistry lab course by outlining how to evaluate and effectively use scientific data in addition to offering students a more hands-on approach with exercises that encourage them to think deeply about the content and to design their own experiments. Instructors will find this book useful because the modular nature of the lab exercises allows them to apply the exercises to any set of proteins and incorporate the exercises into their courses as they see fit, allowing for greater flexibility in the use of the material. Written in a logical, easy-to-understand manner, Experiments in the Purification and Characterization of Enzymes: A Laboratory Manual is an indispensable resource for both students and instructors in the fields of biochemistry, molecular biology, chemistry, pharmaceutical chemistry, and related molecular life sciences such as cell biology, neurosciences, and genetics. Offers project lab formats for students that closely simulate original research projects. Provides instructional guidance for students to design their own experiments . Includes advanced analytical techniques. Contains adaptable modular exercises that allow for the study proteins other than FNR, LuxG and LDH. Includes access to a website with additional resources for instructors"--Page 4 of cover.


Book
Reconstituting the cytoskeleton
Authors: ---
ISBN: 0123979242 0123984807 Year: 2014 Publisher: San Diego, California : Academic Press,

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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers cytoskeletal structure, including such topics as rotational movement of formins studied by fluorescence polarization microscopy, in vitro assembly assays for bacterial actin filaments, and modulators of microtubule plus end growth.Continues the legacy of this premier serial with quality chapters authored by leaders in the fieldCovers cytoskeletal structureContains chapters with such topics as rec


Book
Xylanolytic enzymes
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ISBN: 0128010665 0128010207 9780128010662 9780128010204 Year: 2014 Publisher: Oxford : Academic Press,

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Xylanolytic Enzymes describes the enzyme structure and its interaction with plant cell walls, the properties and production of different enzymes and their application, and the knowledge gathered on the hydrolysis mechanism of hemicellulose. The knowledge gathered about the hydrolysis mechanism of the hemicelluloses, especially xylans, has greatly promoted the rapid application of these enzymes in new areas. Recently there has been much industrial interest in xylan and its hydrolytic enzymatic complex, as a supplement and for the manufacturing of food, drinks, textiles, pulps a


Book
Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
Authors: --- --- ---
ISSN: 21969914 ISBN: 1461491347 1461491355 Year: 2014 Publisher: New York, NY : Springer New York : Imprint: Humana,

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There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development.


Book
Itch : mechanisms and treatment
Authors: ---
ISBN: 1466505435 1466505443 0429098340 Year: 2014 Publisher: Boca Raton : CRC Press,

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Written by leading, internationally-known scholars in itch research and treatment, this volume presents the most current update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cell lymphomas, and systemic diseases such as kidney and liver disease and cancer. The book is designed for basic researchers, clinicians who study and treat itch, pharmaceutical companies interested in developing itch treatments, and anyone else interested in learning about itch--Provided by publisher.


Book
Neurobiology of chemical communication
Author:
ISBN: 1466553413 1466553421 0429162022 Year: 2014 Publisher: Boca Raton : Taylor & Francis,

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The release of pheromones is one of various forms of nonverbal communication many animals use to transmit messages to other members of the same species. Their complex molecular structure allows these chemical messages to contain a great deal of often very specific information. This book provides an overview of recent findings in the field of pheromones and chemical signals in vertebrate and invertebrate species. It includes chapters on how chemical signals work on different species and covers non-mammalian species and mammalian pheremones in general and in particular species.


Book
Oral delivery of insulin
Authors: ---
ISBN: 1908818689 1907568476 0081016255 9781908818683 9781907568473 Year: 2014 Publisher: Cambridge, England : Woodhead Publishing,

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Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and


Book
Interleukins in cancer biology
Authors: ---
ISBN: 0128103256 0128013338 0128011211 130690837X 9780128013335 9781306908375 9780128011218 Year: 2014 Publisher: Boston, MA : Elsevier,

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Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remem


Book
New functional biomaterials for medicine and healthcare
Authors: --- ---
ISBN: 1782422668 178242265X 9781782422662 9781782422655 9781782422655 Year: 2014 Publisher: Philadelphia, PA : Woodhead Pub.,

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Advances in processing technologies and our understanding of materials and their properties have made it possible for scientists and engineers to develop more sophisticated biomaterials with more targeted functionality. This important book provides a concise summary of the latest developments in key types of biomaterials.The book begins with an overview of the use of biomaterials in contemporary healthcare and the process of developing novel biomaterials; the key issues and challenges associated with the design of complex implantable systems are also highlighted. The book then reviews


Book
Polyphenols in plants
Author:
ISBN: 0123984912 012397934X 1306376610 9781306376617 9780123979346 9780123984913 Year: 2014 Publisher: London Academic Press

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Polyphenols play key roles in the growth, regulation and structure of plants and vary widely within different plants. Stress, growth conditions and plant species modify polyphenol structure and content. Techniques to isolate as well as characterize polyphenols are reviewed. As some have adverse effects in mammals their toxicology will be carefully reviewed. Plant scientists and dietary supplement producers will be particularly interested in assessing polyphenol content and factors affecting their composition, to select sources and regulate environmental conditions affecting yield fo

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