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In Nederland worden veel initiatieven ontwikkeld om de opleiding tot klinisch onderzoeker verder te professionaliseren. Methodologie en regelgeving, ook nationaal, worden steeds complexer waardoor het doen van trials een steeds professionelere activiteit wordt. De tijden dat een arts-assistent naast zijn klinische werk nog een klinische studie erbij deed zijn definitief voorbij. Alleszins reden om een Nederlandstalig handboek over dit onderwerp uit te geven.Dit Handboek farmaceutische geneeskunde probeert op een beknopte wijze enkele van de meest relevante zaken rondom clinical trials te verhelderen. De systematische benadering draagt bij tot inzicht in het complete beeld van het geneesmiddel, zowel op gebied van mensgebonden onderzoek, als op het terrein van wet- en regelgeving en kwaliteit.
Pharmacology. Therapy --- klinisch onderzoek (farmacologie) --- farmacologie --- geneesmiddelen
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Comprehensive Guide to Education in Anesthesia is the first single-source volume on the current practice of teaching and learning in this specialty which has long been at the forefront of innovation in medical education. It is edited by one of the great anesthesiology educators in the United States and brings together contributions from leading educators from across the US covering all aspects of anesthesiology education, from medical school and post-graduate training to board certification and continuing medical education. Topics include best educational practices, closed claim analysis, giving feedback to superiors, residency and fellowship training and requirements, maintenance of certification, the role of simulation, interacting with other specialties, community and global outreach, and more. The book conveys the unique nature of the specialty and is aimed at medical students contemplating a career in anesthesiology, residents and fellows, educators, and administrators.
Anesthesiology --- farmacologie --- anesthesie
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There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development.
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Loco-regional anesthesia presents definite advantages in almost all surgical branches, since it couples a perfect anesthesia with a long postoperative analgesia. This discipline is constantly developing thanks to new drugs and new techniques. In the last decade the advent of ultrasound guided regional anesthesia has extended the study from the anatomic room to the virtual but real “in corpore viri” ecographic image thus increasing the success rate of this type of anesthesia. Together with electrostimulation, it has definitely increased the success rate of loco-regional anesthesia. Nonetheless, though supported by new fundamental tools, it is of the utmost importance for anesthesiologists to have a deep knowledge of the brachial plexus and of the topographic anatomy, on which the two first chapters are focused. Featuring a total of 16 chapters and more than 140 color illustrations, the volume provides a detailed coverage of this technique, thus representing a very useful tool for specializing students as well anesthesiologists in their daily clinical practice.
Anesthesiology --- farmacologie --- anesthesie
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35238084
verpleegkundig beroep --- farmacologie --- Nursing --- Pharmacology. Therapy --- geneesmiddelen --- Farmacologie (geneesmiddelenleer) --- 615 --- 605.51 --- medicatie --- verpleegkunde --- Farmacologie. Farmaceutische wetenschappen --- Geneesmiddelen --- Geneesmiddel
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Al vijftien jaar is Praktische psychofarmacologie het Nederlandstalige standaardwerk over farmacotherapie bij psychiatrische patiënten. Meer dan 15.000 exemplaren vonden in deze periode hun weg naar psychiaters, apothekers, huisartsen en andere medische hulpverleners. Deze vijfde, herziene druk is geactualiseerd en uitgebreid met de laatste inzichten op basis van uitgebreid wetenschappelijk literatuuronderzoek. Praktische psychofarmacologie behandelt systematisch de stappen en overwegingen bij het voorschrijven van geneesmiddelen. Deze praktijkgerichte leidraad verdient een plaats in de basisbibliotheek van elke medische professional die te maken krijgt met de behandeling van psychiatrische aandoeningen.
Psychofarmaca. --- geneesmiddeleninformatie --- farmacologie --- Psychiatry --- Pharmacology. Therapy --- psychofarmaca
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The past 50 years have witnessed the growth and evolution of clinical electrophysiology from a field whose goals were simply to understand of the mechanisms of arrhythmia to one of significant therapeutic impact. The development and refinement of implantable devices and catheter ablation have made non-pharmacological therapy a treatment of choice for most arrhythmias encountered in clinical practice. Cardiac Arrhythmias: From Basic Mechanism To State-of-the-Art Management provides an electrophysiologic approach to arrhythmias predicated on the hypothesis that a better understanding of the mechanisms of arrhythmias will lead to more successful and rationally chosen therapy. It encompasses the anatomy of arrhythmias, diagnostic methods, comorbid diseases, and the treatment of all forms of cardiac arrhythmias. It discusses modern ablation and mapping techniques, while reviews the methodology required to define the mechanism and site of origin of arrhythmias, so that safe and effective therapy can be chosen. It will thus be of interest to all involved in the management of these patients, from clinical cardiac electrophysiologists themselves to clinical cardiologists, interventionalists, cardiac surgeons, emergency medicine physicians and researchers in basic cardiac science.
Pathology of the circulatory system --- farmacologie --- cardiologie
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The book presents more than 60 real-life cases which together memorably and succinctly convey the depth and breadth of clinical anesthesiology. Each chapter includes a case summary, questions, lessons learned, and selected references. Tables and distinctive visual synopses of key teaching points enhance many chapters. The cases have been selected by Dr. Benumof from the Morbidity and Mortality (M & M) conferences of the Department of Anesthesiology, University of California, San Diego, which he has moderated the last several years, and residents and junior faculty have crafted them into the chapters of this book. Structured in a novel way, the UCSD Anesthesiology M&Ms maximize teaching and learning, and these cases bring that experience right to the reader’s finger tips. Case coverage of respiration- and circulation-related problems, obstetrics, neurology, pain and regional anesthesia, pediatrics, outpatient surgery, and special topics Resource for anesthesiology and critical care medicine trainees Review tool for board certification or recertification Fun reading – valuable lessons!
Anesthesiology --- farmacologie --- anesthesie --- intensieve zorgen --- vroedkunde
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