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Liver Pathology covers the key entities and diagnoses that pathologists see in daily practice, focusing on the salient H&E histopathology of each entity with concise descriptions of clinical features, differential diagnosis, and references for further study. It provides the opportunity for correlation with clinical data and radiologic and laboratory findings that are essential to correct diagnosis of non-neoplastic disease and correlation with morphologic and immunohistochemical features in the case of neoplastic liver disease. The book presents information in a bulleted format with H&E illust
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Liver. --- Liver Diseases. --- Gastroenterology. --- Hepatology --- Liver Dysfunction --- Disease, Liver --- Diseases, Liver --- Dysfunction, Liver --- Dysfunctions, Liver --- Liver Disease --- Liver Dysfunctions --- Livers --- Liver --- Diseases. --- Diseases --- Alternative treatment.
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Drs. Busuttil and Klintmalm present Transplantation of the Liver, 3rd Edition, which has been thoroughly revised to offer you the latest protocols, surgical approaches, and techniques used in this challenging procedure. Encompassing today's expert knowledge in the field, this medical reference book is an ideal single source for authoritative, up-to-date guidance on every imaginable aspect of liver transplantation. Understand today's full range of transplantation techniques with complete step-by-step descriptions of each, and access the background information and management options for each hepatic disease entity. Take advantage of detailed discussions of everything from pathophysiology and patient and donor selection, to transplantation anesthesia and operative procedures; immunosuppression; postoperative care; and ethical issues.
Liver Transplantation --- Liver Diseases --- surgery --- Liver --- Transplantation. --- Surgery.
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This book presents the most recent advances in the field of liver diseases and surgery, including the remarkable advances in Hepatitis C therapy, liver tumors, injuries, cysts, resections, transplantation, and preoperative management of patients with liver diseases. The editors are the dean and vice deans of the National Liver Institute, Menoufia University, a dedicated international center of excellence and a leading medical institution in the Middle East for the diagnosis and management of liver diseases and advanced training and research in hepatobiliary sciences. The authors are leading experts from four continents across the globe (North America, Europe, Asia, and Africa). In other words, the book team reflects an international dream team of experts in the area of liver diseases.
Liver --- Diseases. --- Hepatology
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Liver Cirrhosis --- Liver Cirrhosis --- Liver Diseases --- Liver --- Foie --- therapy. --- diagnosis. --- complications. --- Cirrhosis. --- Cirrhose
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Hepatology at a Glance is an accessible, illustrated introduction to this increasingly important specialty. This brand new title helps the reader to develop a solid understanding of liver disease, and to recognise, diagnose and treat all types of routinely encountered liver and biliary disorders. It covers key areas such as the development, structure and function of the liver, transplantation, surgery and nutrition. Common cases of liver disorders and scenario, and the management of rarer diseases and disorders in special patient groups such as the pregnant are included. Hepatology at a Glance: Is a unique and concise resource on hepatology created for junior medical staff, Maintains a practical emphasis, with advice on history, examination and clinical testing, Includes clinical scenarios, with self-assessment questions and full explanations to answers, Follows the curriculum set by and with the support of the British Society of Gastroenterology, Includes a companion website at www.ataglanceseries.com/hepatology featuring 30 MCQs. Providing guidance on all vital aspects of the specialty, Hepatology at a Glance is a succinct and accessible summative resource to enable a thorough understanding of the field.
Hepatology. --- Liver --- Diseases.
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"Operative Techniques in Hepato-Pancreatico-Biliary Surgery was produced with the intent to be truly unique and thus essential to surgeons in training, fellowship, and practice. Particular attention is devoted to the rapid evolution of the field of HPB surgery to minimally invasive and robotic approaches. As endoscopic and catheter-based therapies now complement or replace operative approaches, renowned authors from the fields of gastroenterology and radiology provide chapters specifically written for surgeons in the context of multidisciplinary care. Hepato-pancreatico-biliary system operative planning and execution requires a thorough understanding of complex, often variable anatomy and is now routinely based upon cross-sectional imaging of 3-dimensional space. Addressing this challenge was the charge to each author; the result is a liberal use of imaging and intra-operative photography supported by exceptional, consistent artwork. When alternative approaches to those of the author are viable, they are included"--
Liver --- Biliary tract --- Pancreas --- Surgery. --- Diseases.
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Since the first liver transplants, improving immunosuppressive therapy and reducing the incidence of acute rejection have saved many lives. However, some patients develop de novo cancer after liver transplantations, the most commons are skin cancer and post-transplant lymphoproliferative disorder. Their incidence is higher in transplant patients than in the general population. The occurrence of de novo cancer depends on the risk factors to which patients are exposed. A major risk factor is immunosuppression. The stronger the immunosuppression , the greater the risk of developing de novo cancer. Minimizing immunosuppression has a great interest in the medical field which is to reduce the risk of de novo cancer becoming a major cause of mortality in transplant recipients. Other immunosuppressive medications with anti-tumor activity will be introduced in the future to address this important issue . Depuis les premières transplantations hépatiques, l'amélioration des traitements immunosuppresseurs et la réduction de l'incidence des rejets aigus ont permis de sauver beaucoup de vies. Cependant , certains patients développent un cancer de novo après la transplantation hépatique, les plus courants sont le cancer cutané et le syndrome lymphoprolifératif post-transplantation. Leur incidence est beaucoup plus élevée chez les patients transplantés que dans la population générale. L'appar ition du cancer de novo dépend des facteurs de risques auxquels sont exposés les patients. Un des facteurs de risques majeur est l'immunosuppression . Plus fort est l'immunosuppression , plus grand est le risque de développer un cancer de novo. Minimiser l'immunosupp resion a un grand interêt dans le domaine médical, il s'agit de diminuer le risque de cancer de novo devenu une cause importante de mortalié chez les receveurs transplantés. D'autres médications immunosuppresives ayant une activité anti-tumorale seront introduites dans le futur pour faire face à ce problème important.
Liver Transplantation --- Skin Neoplasms --- Lymphoproliferative Disorders
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La stéatose hépatique non alcoolique (NAFLD), manifestation hépatique du syndrome métabolique, peut évoluer vers une stéatohépatite non alcoolique (NASH) caractérisée par des lésions hépatiques (stéatose, inflammation et fibrose). Il manque à ce jour des agents thérapeutiques pour lutter contre la NASH et ses comorbidités. L’activation de TGRS, un récepteur aux acides biliaires, semble être une piste prometteuse. Son activation augmente la dépense énergétique via la régulation de la thermogenèse et améliore l’homéostasie glucidique via la stimulation de la sécrétion de GLP1 dans l’intestin. Le but de ce travail est de déterminer si l’activation de TGRS via un agoniste spécifique, l’INT 777, améliore le phénotype des souris foz/foz, un bon remède animal pour l’étude de la NASH. Des souris foz/foz et WT ont été nourries avec un régime normal ou riche en graisse (HFD) pendant 1 ou 4 semaines respectivement. Elles ont reçu l’INT 777 ou le vecteur (méthylcellulose) par gavage. Les résultats préliminaires montrent que l’administration de l’INT777, chez les souris sous HFD, a tendance à augmenter l’expression des gènes liés à la thermogenèse, tels qu’UCP1 et DIO2 dans le tissu adipeux brun. Cette augmentation de la thermogenèse n’est pas associée à une perte de poids chez les souris WT ou foz/foz recevant l’INT777. De plus, les souris foz/foz sous HFD, l’INT777 tend à améliorer leur tolérance au glucose, associée à une légère augmentation de l’expression de GLP1 dans le jéjunum. Une nouvelle expérience est nécessaire pour déterminer si l’activation des RGR5 permet d’améliorer le phénotype des souris foz/foz.
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Gastroenterology --- Hepatology --- Gastrointestinal Diseases. --- Liver Diseases.
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