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This volume brings together the skills and protocols of numerous laboratories that are at the heart of investigation into the biology of Tfh cells in both mice and humans. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, T follicular Helper Cells: Methods and Protocols provides scientist with techniques and protocols that have facilitated breakthroughs in Tfh biology and to present them in a way that will enable both new and experienced researchers to continue to move this exciting field forward.
Cell physiology. --- Cell Physiology. --- Cell function --- Cytology --- Physiology
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During the second half of the 20th century, the introduction of a variety of new techniques greatly expanded our knowledge of the structure of nerve and neuroglial cells, and of the organization of the nervous system at the cellular level. This new information has, however, generally been scattered throughout the literature, making it difficult for investigators to gain an overall vision of the discipline. The author has marshalled these scattered data to provide a systematic overview of the field placed within a historical context. He has correlated the major new findings with the classical notions of light microscopy and has integrated them with elements of biochemistry and cell physiology. After the publication of the first edition, the introduction of new microscopies and especially the growth of molecular biology have greatly expanded our knowledge, in particular on the intercellular communication in the nervous system and on the roles of neuroglial cells. These achievements have made a second edition of the book necessary. The fully revised and updated text, together with unique high-quality illustrations of structures of the central and peripheral nervous system, ensure that this new edition will be invaluable for neuroscientists, particularly those involved in cellular neuropathology, neurochemistry, neurophysiology, and molecular neurobiology.
Biomedicine. --- Neurosciences. --- Cell Biology. --- Cell Physiology. --- Neurobiology. --- Medicine. --- Cytology. --- Médecine --- Neurosciences --- Cytologie --- Neurobiologie --- Medicine --- Health & Biological Sciences --- Neurology --- Neurons --- Neuroglia --- Ultrastructure. --- Cell biology. --- Cell physiology. --- Ultrastructure (Biology) --- Cell function --- Cytology --- Physiology --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system
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This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 1 addresses cell polarity and cell migration (front-rear polarity), cell polarity and barrier formation (apico-basal polarity) and neuronal polarity. It particularly focuses on cell polarity at the molecular level and the underlying molecular mechanisms. It also elaborates the common principles and mechanisms that regulate cellular polarization in different cell types and contexts. Both volumes are intended for professors, group leaders and researchers in cell biology as well as medical professionals in the fields of anatomy, cell biology, physiology, pathology and tumor biology.
Life Sciences. --- Cell Physiology. --- Cancer Research. --- Human Physiology. --- Life sciences. --- Oncology. --- Human physiology. --- Cytology. --- Sciences de la vie --- Cancérologie --- Physiologie humaine --- Cytologie --- Cells. --- Polarity (Biology). --- Biology --- Health & Biological Sciences --- Cytology --- Polarity (Biology) --- Cell biology --- Cellular biology --- Cancer research. --- Cell physiology. --- Cells --- Cytologists --- Tissues --- Human biology --- Medical sciences --- Physiology --- Human body --- Tumors --- Cell function --- Cancer research
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This volume explores the cytoskeleton, examining its structural and functional roles and its dysfunctions which often lead to disease. Microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems are thoroughly discussed. The text is organized into four sections, each of which covers specific subtopics. These consist of an introductory chapter followed by topics of current interest and expert-provided contributions which include each topic's key cell and molecular details. Comprehensive yet concise, The Cytoskeleton in Health and Disease presents cutting- edge new knowledge balanced with background information, both of which are readily understandable for the newcomer and for the experienced researcher alike. The book highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. This book will be essential reading for scientists, students, teachers who are interested in expanding their knowledge related to the cytoskeleton for diagnostic, therapeutic or research-based purposes.
Life Sciences. --- Cell Physiology. --- Cell Cycle Analysis. --- Life sciences. --- Cell cycle. --- Cytology. --- Sciences de la vie --- Cycle cellulaire --- Cytologie --- Cytoskeleton --- Microtubules --- Microtubule Proteins --- Microfilament Proteins --- Physiology --- Biopolymers --- Biological Science Disciplines --- Cytoplasmic Structures --- Polymers --- Natural Science Disciplines --- Cytoplasm --- Disciplines and Occupations --- Macromolecular Substances --- Intracellular Space --- Chemicals and Drugs --- Cellular Structures --- Cells --- Anatomy --- Cytology --- Biology --- Health & Biological Sciences --- Cytoskeleton. --- Cell skeleton --- Skeleton, Cell --- Cell physiology. --- Mitotic cycle --- Nuclear cycle (Cytology) --- Biological rhythms --- Cell function
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This book highlights the known associations between the kynurenine pathway and various disease states and also examines the current state of drug development and clinical trials of compounds known to alter tryptophan metabolism. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It explores the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available. This book also: · Combines basic understanding of the role of the kynurenine pathway with translational applications and clinical relevance · Explains the role of the kynurenine pathway in various disease states · Explores ongoing clinical trials using IDO/TDO inhibitors.
Biochemistry --- Chemistry --- Physical Sciences & Mathematics --- Molecular biology. --- Kynurenine --- Life sciences. --- Pathophysiology. --- Biosciences --- Sciences, Life --- Molecular biochemistry --- Molecular biophysics --- Neurochemistry. --- Proteins. --- Enzymology. --- Cell physiology. --- Life Sciences. --- Protein Structure. --- Molecular Medicine. --- Cell Physiology. --- Science --- Biophysics --- Biomolecules --- Systems biology --- Tryptophan --- Enzymes. --- Biochemistry. --- Medicine. --- Neurosciences --- Cell function --- Cytology --- Physiology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymology --- Composition --- Health Workforce --- Proteins . --- Proteids --- Polypeptides --- Proteomics --- Enzymes
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This book consists of 23 essays about prominent people and events in the history of respiratory physiology. It provides a first-hand chronicle of the advancements made in respiratory physiology starting with Galen and the beginnings of Western physiology. The volume covers many aspects of the evolution of this important area of knowledge: pulmonary circulation, Boyle’s Law, pulmonary capillaries and alveoli, morphology, gas exchange and blood flow, mechanics, control of ventilation, and comparative physiology. The book emphasizes societal and philosophical aspects of the history of science. Although it concentrates on physiology, it also describes how cultural movements, such as The Enlightenment, shaped the researchers discussed.
Medicine & Public Health. --- History of Medicine. --- Human Physiology. --- Cell Physiology. --- Pneumology/Respiratory System. --- Evolutionary Biology. --- Medicine. --- Human physiology. --- Pneumology. --- Cytology. --- Evolution (Biology). --- Médecine --- Physiologie humaine --- Cytologie --- Evolution (Biologie) --- Respiratory Function Tests. --- Medicine --- Health & Biological Sciences --- History of Medicine --- Respiratory organs --- Respiration --- Physiology --- History. --- Animal respiration --- Animals --- Breathing --- Ventilation (Physiology) --- Air passages (Anatomy) --- Respiratory system --- Cell physiology. --- Evolutionary biology. --- Diseases. --- Vital signs --- Aerobic exercises --- Breathing exercises --- Cardiopulmonary system --- Human biology --- Medical sciences --- Human body --- Animal evolution --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Cell function --- Cytology --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Health Workforce --- Medicine—History. --- Respiratory organs—Diseases.
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This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.
Engineering. --- Biomedical Engineering. --- Cell Physiology. --- Physics of the Cell. --- Biomaterials. --- Cytology. --- Biomedical engineering. --- Ingénierie --- Cytologie --- Génie biomédical --- Engineering --- Cytology --- Biomedical engineering --- Biomaterials --- Health & Biological Sciences --- Biomedical Engineering --- Obesity --- Molecular aspects. --- Adiposity --- Corpulence --- Fatness --- Overweight --- Cell physiology. --- Biological and Medical Physics, Biophysics. --- Body weight --- Metabolism --- Nutrition disorders --- Disorders --- Biomedical Engineering and Bioengineering. --- Cell function --- Physiology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Medicine --- Biocompatible materials --- Medical materials --- Materials --- Biocompatibility --- Prosthesis --- Biophysics. --- Biological physics. --- Bioartificial materials --- Hemocompatible materials --- Biological physics --- Biology --- Medical sciences --- Physics --- Biomaterials (Biomedical materials)
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Respiratory allergy is constantly encountered and is sharply on the rise, particularly in the two most vulnerable age-groups: young children and seniors. Allergy results in airway hyperactivity and increased airway resistance, with all inflammatory sequelae being ensued. The chapters show how respiratory allergy research is interconnected with other disciplines by discussing neurotransmitter, membrane receptor, and ionic channel mechanisms of allergy and by giving diagnostic and pharmacological cues on desensitization and therapy.
Biomedicine. --- Biomedicine general. --- Allergology. --- Pneumology/Respiratory System. --- Medical Biochemistry. --- Pharmacotherapy. --- Cell Physiology. --- Medicine. --- Allergy. --- Pneumology. --- Biochemistry. --- Cytology. --- Médecine --- Allergie --- Biochimie --- Cytologie --- Respiratory allergy. --- Respiratory organs --- Medical biochemistry. --- Cell physiology. --- Diseases. --- Cell function --- Cytology --- Physiology --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Drugs --- Pharmacology --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Respiratory diseases --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Allergy --- Diseases --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Composition --- Respiratory organs—Diseases. --- Biomedicine, general. --- Health Workforce
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This book covers both the technological development and biomedical applications of NADH fluorescence. Topics covered include perspectives on the history of monitoring NADH fluorescence, the relationship between mitochondrial function and other functions at the tissue level, responses of NADH to physiological and pathophysiological conditions, monitoring of NADH in the human brain and other organs, and metabolism. It also includes an in-depth look at flavoprotein (Fp) fluorescence and NADH in relation to redox state. This is an ideal book for biomedical engineers, researchers, and graduate students interested in learning the biomedical applications of NADH fluorescence. This book also: Covers multisite monitoring of NADH, as well as multiparametric responses of NADH to physiological and pathophysiological conditions, and monitoring of various organs in various animal models Describes the relationship between brain activation (i.e. epileptic activity and cortical spreading depression) and NADH redox state Presents the effects of hypoxia, hyperbaric hyperoxia, and ischemia on brain NADH fluorescence and other tissue physiological parameters About the Author Avraham Mayevsky, Ph.D. is a Professor Emeritus in the Faculty of Life Sciences and the Brain Research Center at Bar Ilan University, Israel. He has published more than two hundred papers in the field of mitochondrial function and tissue physiology in vivo under pathophysiological conditions.
Life Sciences. --- Cell Physiology. --- Optics, Optoelectronics, Plasmonics and Optical Devices. --- Biochemistry, general. --- Medical Biochemistry. --- Life sciences. --- Biochemistry. --- Cytology. --- Sciences de la vie --- Biochimie --- Cytologie --- Biology --- Health & Biological Sciences --- Cytology --- Mitochondria --- Chondriosomes --- Medical biochemistry. --- Cell physiology. --- Optics, Lasers, Photonics, Optical Devices. --- Cell organelles --- Protoplasm --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Cell function --- Physiology --- Composition --- Lasers. --- Photonics. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- New optics --- Optics --- Light amplification by stimulated emission of radiation --- Masers, Optical --- Optical masers --- Light amplifiers --- Light sources --- Optoelectronic devices --- Nonlinear optics --- Optical parametric oscillators
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This atlas provides a detailed insight into the complex structure and organization of cells and tissues, highlights specific cellular and tissue functions, and the dynamics of diverse intracellular processes. Highly informative electron micrographs are complemented by explanatory texts, selected references and schemes. The concept that subcellular organelles provide the structural foundation for fundamental processes of living organisms is emphasized. The first part covers the cellular organelles and changes caused by experiments or occurring under pathological conditions. The second part illustrates by selected examples principles of functional tissue organization and typical changes resulting from experimental induction or pathological situations. The third edition of the atlas, revised and extended by 23 plates, thus provides an invaluable resource for scientists and students of medicine and biological sciences, particularly of histology, cell and molecular biology. Moreover, it will serve as a handy reference guide for diagnostic and research electron microscopy laboratories in clinical, industrial, and academic settings.
Life Sciences. --- Cell Physiology. --- Biological Microscopy. --- Pathology. --- Medical Biochemistry. --- Medical Microbiology. --- Life sciences. --- Microbiology. --- Biochemistry. --- Cytology. --- Microscopy. --- Sciences de la vie --- Microbiologie --- Biochimie --- Pathologie --- Cytologie --- Microscopie --- Biology --- Health & Biological Sciences --- Cytology --- Ultrastructure (Biology) --- Medical microbiology. --- Medical biochemistry. --- Cell physiology. --- Microbial biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Disease (Pathology) --- Diseases --- Medicine --- Medicine, Preventive --- Analysis, Microscopic --- Light microscopy --- Micrographic analysis --- Microscope and microscopy --- Microscopic analysis --- Optical microscopy --- Optics --- Cell function --- Physiology --- Composition --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology
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