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Aimed at ""drug discoverers"" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation,

Molecular neurobiology. --- Nervous system --- Diseases. --- Medical neurology --- Nerves --- Neurologic disorders --- Neurological disorders --- Neuropathology --- Neurology --- Molecular neurology --- Molecular biology --- Neurobiology --- Diseases --- Molecular aspects

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Motor Neuron Disease in Adults reviews new information as it applies to all aspects of motor neuron disease (ALS, PLS, PMA). The choice of articles is for those that use evidence-based methods to ensure that the new information is solid and advances the topic or issue. The book can be used by anyone who provides any type of care to ALS patients. In particular, neurologists will find the latest information on diagnosis and management, as well as new information on genetics and frontotemporal lobe involvement. Allied health providers will find useful information for their discipline. Patients wi

Nervous system --- Neurology. --- Amyotrophic lateral sclerosis. --- ALS (Disease) --- Gehrig's disease --- Lateral sclerosis --- Lou Gehrig's disease --- Motor neurone disease --- Sclerosis, Amyotrophic lateral --- Motor neurons --- Neuromuscular diseases --- Medicine --- Neuropsychiatry --- Medical neurology --- Nerves --- Neurologic disorders --- Neurological disorders --- Neuropathology --- Neurology --- Diseases. --- Diseases

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This concise text delivers a basic introduction to neurology and is designed for use by medical students during their rotation in neurology and related disciplines. Updated and expanded, this second edition follows the same order as the first, starting with how to approach a patient with a neurologic problem followed by the latest information on the phenomenology, pathophysiology and symptoms of common adult and pediatric neurologic diseases.  Supplementing the learning experience are clinical cases that begin each chapter and videos of examples ranging from how to perform the normal neurologic exam to abnormal exam findings.    Easy-to-read and richly illustrated, Fundamentals of Neurologic Disease, 2nd Edition is an invaluable resource for anyone seeking to learn the fundamentals of neurology.

Medicine & Public Health. --- Primary Care Medicine. --- Neurology. --- Internal Medicine. --- Medicine. --- Internal medicine. --- Emergency medicine. --- Médecine --- Médecine interne --- Neurologie --- Médecine d'urgence --- Neurology --- Nervous system --- Public Health --- Health & Biological Sciences --- Public Health - General --- Diseases --- Diseases. --- Medical neurology --- Nerves --- Neuropathology --- Primary care (Medicine). --- Medicine --- Neuropsychiatry --- Neurologic disorders --- Neurological disorders --- Medicine, Internal --- Medicine, Emergency --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Neurology . --- Primary medical care --- Medical care

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Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use.

Neurosciences --- Nervous system --- Drug development. --- Development of drugs --- Drugs --- New drug development --- Medical neurology --- Nerves --- Neuropathology --- Neural sciences --- Neurological sciences --- Neuroscience --- Research. --- Diseases. --- Development --- Diseases --- Pharmacology --- Pharmacy --- Neurologic disorders --- Neurological disorders --- Neurology --- Medical sciences --- NEUROSCIENCE/General --- BIOMEDICAL SCIENCES/General --- Strüngmann Forum Reports --- translational neuroscience --- diagnostics --- biomarkers

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Optical coherence tomography (OCT) provides tissue morphology imagery at much higher resolution than other imaging modalities such as MRI or ultrasound, and the machines are comparatively cheaper. It is an easy technique to perform; is non-ionizing, and therefore safe. These benefits are driving a rapid transformation of OCT, from its principal application as a research tool, into an extension of the 'neurological examination' in routine office practice. Originally used in assessing the severity of tissue damage and prognosis of multiple sclerosis and various neuro-ophthalmic conditions, OCT is increasingly used in other neurological disorders such as Parkinson's disease, ALS, and Alzheimer's disease. This book is the first comprehensive review of the use of OCT in neurological diseases. The coverage includes a description of the technique and its utilization in a variety of neurologic conditions. Essential reading for neurologists, neuro-ophthalmologists, and neuroradiologists wanting an introductory account of the clinical applications of OCT.

Medicine. --- Nervous system diseases -- Diagnosis. --- Nervous system diseases -- Treatment. --- Tomography, Optical coherence. --- Diseases --- Tomography, Optical --- Tomography --- Diagnostic Imaging --- Diagnostic Techniques and Procedures --- Diagnosis --- Nervous System Diseases --- Tomography, Optical Coherence --- Medicine --- Health & Biological Sciences --- Neurology --- OCT Tomography --- Optical Coherence Tomography --- Coherence Tomography, Optical --- Tomography, OCT --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Diagnose --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Disease --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Diagnostic Testing --- Testing, Diagnostic --- Sensitivity and Specificity --- Imaging, Diagnostic --- Imaging, Medical --- Medical Imaging --- Radiologic and Imaging Nursing --- Image Processing, Computer-Assisted --- Tomographies --- Anatomy, Cross-Sectional --- Optical Tomography --- diagnosis --- methods --- Nervous system --- Central nervous system --- Diagnosis. --- Tomography. --- Nervous system, Central