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This book describes the diverse roles that growth factors and cytokines play in skeletal muscle. The extracellular environment has profound effects on the biology of skeletal muscle. The soluble portion of this environment includes a rich milieu of growth factors and cytokines which have been shown to regulate virtually all facets of the response of skeletal muscle to external stimuli, whether it be exercise induced metabolic shifts, remodeling in response to trauma or loading of the ongoing pathology associated with neuromuscular disease. The chapters included in this work illustrate growth factors that directly affect skeletal muscle cells and those which influence non-muscle cells that contribute to the biology of skeletal muscle as a whole tissue. The current state of the art, with the advent of systems biology, allows for the delineation of signaling networks which are regulated by suites of growth factors. This is in stark contrast to early more traditional studies, which only examined the effects of isolated growth factors on the activity of skeletal muscle precursor cells in tissue culture. The work presented in this volume ranges from reviewing and analyzing the roles of individual growth factors in detail, to the complex interplay of multiple soluble factors in the control of muscle functional, and dysfunctional states. The material covered in this volume will particularly suit readers from a range of research fields spanning general muscle biology and physiology, and those working on diseases and conditions affecting skeletal muscle both directly and indirectly.

Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Muscles --- Musculoskeletal system. --- Muscle cells. --- Regeneration. --- Myocytes --- Locomotor system --- Musculo-skeletal system --- Skeletomuscular system --- Cells --- Cytokines. --- Human physiology. --- Biochemistry. --- Cytokines and Growth Factors. --- Human Physiology. --- Medical Biochemistry. --- Human biology --- Medical sciences --- Physiology --- Human body --- Cellular immunity --- Immune response --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Regulation --- Composition --- Muscle, Skeletal. --- Intercellular Signaling Peptides and Proteins. --- Growth Factors --- Paracrine Peptide Factors --- Paracrine Protein Factors --- Peptide Factors, Paracrine --- Paracrine Communication --- Peptide Hormones --- Anterior Tibial Muscle --- Gastrocnemius Muscle --- Muscle, Voluntary --- Plantaris Muscle --- Skeletal Muscle --- Soleus Muscle --- Muscle, Anterior Tibial --- Muscle, Gastrocnemius --- Muscle, Plantaris --- Muscle, Soleus --- Muscles, Skeletal --- Muscles, Voluntary --- Skeletal Muscles --- Tibial Muscle, Anterior --- Voluntary Muscle --- Voluntary Muscles --- Growth factors. --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides