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DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.

Genetics --- Histology. Cytology --- Molecular biology --- Biology --- biologie --- cytologie --- histologie --- moleculaire biologie --- genexpressie --- enzymen

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This book explores key applications of phage biotechnology and reviews recent advances in phage display technologies. The applications covered were selected on the basis of their significance and representativeness in the field. The small size and enormous diversity of bacteriophages make them ideal candidates for numerous applications across many industries. Since the discovery of phages and the advent of phage display systems, considerable attention has been focused on the development of novel therapeutic and industrial applications. Recent studies combine the genomic flexibility of phages with phage display systems in order to generate modified phages for targeted delivery.

Descriptive organic chemistry --- Chemistry --- Genetics --- Molecular biology --- Biochemical engineering --- bio-engineering --- biochemie --- chemie --- biotechnologie --- moleculaire biologie --- genexpressie

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This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.

Genetics --- Molecular biology --- Human physiology --- Pathological biochemistry --- Pathological endocrinology --- Human medicine --- medische biochemie --- biochemie --- biomedische wetenschappen --- endocrinologie --- fysiologie --- moleculaire biologie --- genexpressie

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This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.

Chemical structure --- Chemistry --- Genetics --- Molecular biology --- Pathological biochemistry --- Human medicine --- moleculaire structuur --- medische biochemie --- biochemie --- biomedische wetenschappen --- eiwitten --- moleculaire biologie --- genexpressie --- proteïnen

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Genetics professor Michelle Murphy loses her husband under mysterious circumstances and without warning, while their brilliant eight-year-old daughter Avalon, adopted in Kazakhstan, stubbornly believes she is a mutant. As if this were not enough, she soon finds herself thrown into the middle of a quickly thickening plot, where the legacy of Genghis Khan meets the hunt for FOXP5, a genetic transcription factor that could herald the dawn of new human species. Initially caught helplessly between well-meaning fellow scientists, the government, and more sinister agents, Michelle eventually takes control with the help of a host of unlikely heroes and finds the courage to confront the decision of whether to save human lives or humanity. The scientific and technical aspects underlying the plot – in particular aspects of FOX proteins, genetic mutations, viruses, and cancer as well as the relation between intelligence and cortical complexity – are introduced and discussed by the authors in an extensive, non-technical appendix. Science writer Wallace Kaufman’s work has appeared in major magazines and newspapers in the U.S., England, and Kazakhstan. After Duke University he earned an M.Litt. from Oxford. His writing has taken him to Central and South America, to European Russia and the coasts of Siberia. He worked in most of Central Asia and served as resident adviser on housing and land reform in Kazakhstan. His books include Invasive Plants: Guide to Identification and the Impacts and Control of Common North American Species (2nd edition, 2013), Coming Out of the Woods - A Memoir (2001), No Turning Back (1994), and The Beaches Are Moving: The Drowning of America's Shoreline, (1979/1983). David Deamer is a Research Professor of Biomolecular Engineering at the University of California, Santa Cruz. He recently published First Life: Discovering the Connections between Stars, Cells, and How Life Began (2011). Deamer's research concerns molecular self-assembly processes related to the origin and evolution of membrane structure. Over the past 25 years, he has been engaged in developing nanoscopic pores in lipid bilayers as a way to sequence DNA. This work came to fruition in 2015 when the first portable nanopore sequencing device was successfully tested by early users. .

Science --- Sociology of health --- Evolution. Phylogeny --- Genetics --- Molecular biology --- Pure sciences. Natural sciences --- Hygiene. Public health. Protection --- Human medicine --- Linguistics --- mutaties --- popularisering wetenschap --- populaire cultuur --- gezondheid --- wetenschap --- geneeskunde --- Europees recht --- moleculaire biologie --- genexpressie