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The effective management of Cardiac remodeling(CR), remains a major challenge. Heart failure remains the leading cause of death in industrialized countries. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising agents were found to decrease mortality in patients recovering from myocardial infarction. Cardiac remodeling is defined as molecular and interstitial changes, manifested clinically by changes in size, mass , geometry and function of the heart in response to certain aggression. Initially, ventricular remodeling aims to maintain stable cardiac function in situations of aggression.

Fibrosis --- Heart Failure --- Physiology --- Inflammation --- Cardiac Remodeling

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Cardiac arrest. --- Arrest, Cardiac --- Cardiopulmonary arrest --- Heart arrest --- Sudden cardiac death --- Heart --- Heart failure --- Diseases

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Sympathetic overactivity is associated with the development of hypertension. Renal denervation (RDN) prevents or delays hypertension in a variety of animal models, which laid the groundwork for the introduction of RDN as a clinical therapy in humans. In 2007, a novel, minimally invasive RDN ablation catheter was first trialled in hypertensive patients, with a 93% success rate of lowering blood pressure for at least three years post-RDN. However, a large scale, sham-controlled clinical trial (Symplicity HTN -3) failed to show reductions in BP greater than sham. The aim of this research topic was to evaluate the efficacy and safety of RDN, to explore the contribution of both afferent and efferent renal nerve activity to hypertension and non-hypertension disorders, and to stimulate future research to better understand the function of the renal nerves and the effects of RDN by highlighting gaps in knowledge.

atherosclerosis --- heart failure --- renal denervation --- renal sympathetic nerves --- kidney disease --- hypertension

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This book provides a road map for defining the care of acute heart failure (HF) patients in the short stay or observation unit setting. Supported by the Society of Cardiovascular Patient Care, it presents a description of the problem, defines the measures of success, elucidates the implementation of interventions required to be successful, and provides the tools to insure quality HF management. Fully updated and revised, the Third Edition discusses administrative and regulatory issues relating to HF management; pathophysiology and demographics of acute HF; emergency medical services and emergency department assessment and treatment of acute HF; admission, treatment, and disposition of acute heart failure in observation units; complications and future research; and resources such as clinical pathways, algorithms, and patient education tools that can be directly utilized in various healthcare settings. Short Stay Management of Acute Heart Failure, Third Edition, is an essential guide for cardiologists, emergency physicians, and hospital administrators, as well as for institutions wishing to be recognized as quality heart failure centers. .

Pathology of the circulatory system --- Human medicine --- spoedgevallen --- cardiologie --- Hospitals --- Heart failure --- Congestive heart failure --- Cardiac failure --- Cardiac insufficiency --- Failure, Heart --- Insufficiency, Cardiac --- Heart --- Cardiac arrest --- Benevolent institutions --- Infirmaries --- Health facilities --- Emergency services --- Diseases --- Cardiology. --- Emergency medicine. --- Emergency Medicine. --- Medicine, Emergency --- Medicine --- Critical care medicine --- Disaster medicine --- Medical emergencies --- Internal medicine

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This book is a comprehensive overview of heart failure and cardiac transplantation and integrates scientific and clinical information about the physiology, pathophysiology, diagnosis, and treatment of this disorder. Organized into five parts, it reviews the history and basic mechanisms of heart failure; etiology of heart failure; heart failure disease progression; advanced therapies for heart failure; and cardiac transplantation. The book presents basic concepts in the physiology, molecular biology, pathology, and epidemiology of the normal and failing heart; known causes of heart failure, such as right heart failure, valvular cardiomyopathy, molecular mechanisms of sarcomeric cardiomyopathies, and neuromuscular cardiomyopathy; cardiorenal syndrome; neurohormonal activation; cardiac resynchronization, ventricular assist devices; regenerative mechanisms; orthotopic heart transplantation; early and late management of the post-transplant patient; heart transplantation and antibody-mediated rejections; heart-lung transplantation; and cardiac xenotransplantation. Featuring contributions from leaders in the fields of heart failure, cardiac transplantation, cardiac pathology, and cardiovascular molecular research, Congestive Heart Failure and Cardiac Transplantation is a valuable compendium for cardiologists, cardiothoracic surgeons, researchers, trainees, and students. .

Medicine. --- Cardiology. --- Cardiac surgery. --- Thoracic surgery. --- Surgical transplantation. --- Medicine & Public Health. --- Transplant Surgery. --- Thoracic Surgery. --- Cardiac Surgery. --- Congestive heart failure. --- Heart --- Transplantation. --- Heart transplantation --- Heart transplants --- Transplants, Heart --- Heart failure --- Surgery --- Transplantation of organs, tissu. --- Surgery. --- Cardiac surgery --- Open-heart surgery --- Thoracic surgery --- Thoracic surgeons --- Internal medicine --- Diseases --- Medical transplantation --- Organ transplantation --- Organ transplants --- Organs (Anatomy) --- Surgical transplantation --- Tissue transplantation --- Tissues --- Transplant surgery --- Transplantation surgery --- Transplants, Organ --- Preservation of organs, tissues, etc. --- Procurement of organs, tissues, etc. --- Transplantation