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Protease inhibitors. --- Proteolytic enzymes. --- Virus inhibitors. --- Antiviruses --- Antiviral agents --- Viruses --- Peptide hydrolases --- Proteases --- Hydrolases --- Proteolytic enzyme inhibitors --- Proteolytic enzymes --- Enzyme inhibitors --- Inhibitors

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Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition. Contents Structure and Function of the Proteasome Approaches to Model Proteasome Dynamics Comparison of the Dynamics of Proteasome Subtypes Inhibitor Influence on the Catalytic Subunits  Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model  Target Groups Lecturers and students of systems biology, immunology and cell biology Practitioners from the fields of systems biology, immunology and cell biology About the Author Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

Medicine. --- Immunology. --- Bioinformatics. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Proteomics. --- Proteolytic enzymes. --- Bayesian statistical decision theory. --- Bayes' solution --- Bayesian analysis --- Statistical decision --- Peptide hydrolases --- Proteases --- Hydrolases --- Molecular biology --- Proteins --- Cytology. --- Immunobiology --- Life sciences --- Serology --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Data processing

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This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.   Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Medicine. --- Cancer research. --- Human physiology. --- Molecular biology. --- Pharmaceutical technology. --- Biomedicine. --- Human Physiology. --- Molecular Medicine. --- Pharmaceutical Sciences/Technology. --- Cancer Research. --- Proteolytic enzymes. --- Proteolytic enzymes --- Pathophysiology. --- Peptide hydrolases --- Proteases --- Hydrolases --- Oncology. --- Tumors --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Physiology --- Human body --- Health Workforce --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology