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Breast --- Biochemical markers. --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Biochemistry --- Indicators (Biology) --- Cancer --- Treatment.

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Biochemical markers. --- Biomedical engineering. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Biochemistry --- Indicators (Biology)

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Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care. The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine. It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.

Life sciences. --- Gene expression. --- Gene therapy. --- Proteomics. --- Life Sciences. --- Gene Expression. --- Gene Therapy. --- Neuropsychiatry --- Biochemical markers. --- Research --- Methodology. --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Behavioral neurology --- Biochemistry --- Indicators (Biology) --- Biological psychiatry --- Neurology --- Molecular biology --- Proteins --- Therapy, Gene --- Genetic engineering --- Therapeutics --- Genes --- Genetic regulation --- Expression

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The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

Medicine. --- Human physiology. --- Molecular biology. --- Cardiology. --- Biomedicine. --- Molecular Medicine. --- Human Physiology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Heart --- Internal medicine --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Physiology --- Human body --- Diseases --- Cardiovascular system --- Biochemical markers. --- Molecular aspects. --- Pathophysiology. --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Indicators (Biology) --- Circulatory system --- Vascular system --- Blood --- Circulation

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General biochemistry --- Human medicine --- Kidneys --- Biochemical markers. --- Kidney Diseases --- Biomarkers. --- Diseases --- Molecular diagnosis. --- Biochemical Marker --- Biologic Marker --- Biologic Markers --- Clinical Marker --- Immune Marker --- Immune Markers --- Immunologic Marker --- Laboratory Marker --- Marker, Biochemical --- Marker, Biological --- Marker, Clinical --- Marker, Immunologic --- Marker, Laboratory --- Marker, Serum --- Marker, Surrogate --- Serum Marker --- Surrogate End Point --- Surrogate End Points --- Surrogate Endpoint --- Surrogate Endpoints --- Surrogate Marker --- Viral Marker --- Biochemical Markers --- Biological Markers --- Biomarker --- Clinical Markers --- Immunologic Markers --- Laboratory Markers --- Markers, Biochemical --- Markers, Biological --- Markers, Clinical --- Markers, Immunologic --- Markers, Laboratory --- Markers, Serum --- Markers, Surrogate --- Markers, Viral --- Serum Markers --- Surrogate Markers --- Viral Markers --- Biological Marker --- End Point, Surrogate --- End Points, Surrogate --- Endpoint, Surrogate --- Endpoints, Surrogate --- Marker, Biologic --- Marker, Immune --- Marker, Viral --- Markers, Biologic --- Markers, Immune --- Molecular Probes --- Endophenotypes --- Biologic markers --- Biological markers --- Biomarkers --- Biochemistry --- Indicators (Biology) --- Abdomen --- Urinary organs --- Nephrology --- Disease, Kidney --- Diseases, Kidney --- Kidney Disease --- Renal Replacement Therapy