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"During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli. Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels. Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological conditions. With chapters contributed by renowned experts in the field, Neurobiology of TRP Channels contains a state- of- the- art overview of our knowledge of TRP channels, ranging from structure to their functions in organismal physiology.? Features: Contains chapters on the roles of several TRP ion channels with a diversity of physiological functions, providing a complete picture of the widespread importance of these proteins. Presents an overview of the structure of TRP channels, including the roles of these proteins in different physiological processes. Discusses the roles of TRP channels in pathophysiological processes, further highlighting their importance. Features several full color illustrations to allow the reader better comprehension of TRP channels.A volume in the Frontiers in Neuroscience series"--Provided by publisher.

TRP channels. --- Membrane proteins. --- Ion channels. --- Neurobiology. --- Biochemistry.

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This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry.

Notch proteins. --- Medicine. --- Cancer research. --- Immunology. --- Biomedicine. --- Cancer Research. --- Membrane proteins --- Notch genes --- Oncology. --- Tumors --- Immunobiology --- Life sciences --- Serology --- Cancer research

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This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians. What sets TRPCs apart from other subfamilies in TRPs is that their activation, stimulated by a membrane receptor-phospholipid C (PLC) cascade, contributes to the slow and sustained elevation of intracellular free calcium. Calcium ions, one of the most important types of second messengers, mediate a variety of physiological functions in the brain, including progenitor cell proliferation, dendritic formation, synaptic transmission and neuronal survival. All TRPCs except TRPC7 have been found in various regions of the brain, including the cerebrum, cerebellum, forebrain and hippocampus. This book provides students and investigators with comprehensive information on the regulation, function and potential of TRPCs and brain diseases in order to attract more attention to this field.

Medicine. --- Cancer research. --- Neurosciences. --- Pharmacology. --- Biochemistry. --- Biomedicine. --- Biochemistry, general. --- Cancer Research. --- Pharmacology/Toxicology. --- Brain --- TRP channels. --- Pathophysiology. --- Diseases. --- Brain diseases --- Transient receptor potential channels --- TRP proteins --- Cerebrum --- Mind --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Physiological effect --- Psychology, Pathological --- Ion channels --- Membrane proteins --- Central nervous system --- Head --- Oncology. --- Toxicology. --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology