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Staphylococcus aureus infections. --- Staphylococcal infections

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Le staphylocoque doré est une des bactéries la plus présente dans notre environnement et elle peut causer diverses pathologies. L'Homme a mis au point des molécules biocides afin de contrer les bactéries pathogènes qui constitue la classe des antibiotiques. A cause de la résistance bactérienne, les antibiotiques ont des applications de plus en plus limitées et il est nécessaire de trouver des alternatives. Une alternative est l'utilisation de peptide antimicrobien et un peptide antimicrobien en particulier est la Pro3-TL. Néanmoins, ces peptides ne peuvent pas être administrés directement par voie orale, il est donc nécessaire d'encapsuler ceux-ci dans des microgels afin de les protéger des enzymes de la sphère intestinale. Par soucis environnemental, ces microgels sont synthétisés en CO2 supercritique qui est une technique permettant de se passer de solvant. Néanmoins, un agent de stabilisation doit être préalablement synthétisé afin de permettre la bonne dispersion de ces microgels. Cet agent de stabilisation possède une partie poly(oxyde d'éthylène) (PEO) et une partie poly(acrylate de perfluorodécyle) (PFDA) avec, entre ces deux parties, un groupement photo-clivable qui aura sont importance dans la suite. Une fois ces microgels synthétisés, des tests antibactériens vont être effectués afin de déterminer la cinétique de relargage du peptide au travers les pores du microgels. Dans un deuxième temps, grâce au clivage du bloc fluoré, il est possible de réalisé une amination réductrice, à la surface des microgels, entre l'amine terminale d'un peptide et l'aldéhyde formée à la surface des microgels lors du clivage de la partie fluorée. Il sera donc possible de cibler spécifiquement les staphylocoques dorés en greffant un peptide de ciblage à leur surface.

Microgels --- Staphylococcus Aureus --- Supercritical carbon dioxide --- Antibacterial peptide --- Physique, chimie, mathématiques & sciences de la terre > Chimie

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The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. The volumes will appear online before they are published in a printed book. Articles are selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments. Volume 19 focusses on Purinergic receptors, also termed purinoceptors. These are plasma membrane proteins present in nearly all mammalian tissues. They participate in a number of cell functions that include proliferation and migration of neural stem cells, vascular reactivity, apoptosis and cytokine secretion and have been associated with learning and memory, feeding conduct, movement and sleep. They facilitate relaxation of smooth muscle of the gut in response to adenosine (P1 receptors) or ATP (P2 receptors). The chapters in this volume are authored by experts in the field. They deal with aspects of structure and biological activity of selected receptor proteins. The first chapter in this volume reviews the current research on the Mechanism of channel gating and regulation of the activity of calcium-activated chloride channel ANO1. This is followed by a chapter dealing with Structure and function of the two-component cytotoxins of Staphylococcus aureus and a chapter on Membrane Fusion and Infection involving the Influenza virus Hemagglutinin. The fourth chapter reviews the impact of arrhythmogenic mutations through the structural determination of the L-type voltage-gated calcium channel. Then there is a chapter that discusses some open questions pertaining to histone post-translational modifications and nucleosome organization in transcriptional regulation. The next chapter deals with regulation of the extracellular SERPINA5 (protein C inhibitor) penetration through cellular membranes. This is followed by a chapter on coding of Class I and II aminoacyl-tRNA synthetases; a chapter on regulation of nephrin phosphorylation in diabetes and chronic kidney injury and a chapter on The Structure-Forming Juncture in oxidative protein folding and the events in the ER. Finally the last chapter deals with the polyspecificity of anti-lipid antibodies and its relevance to the development of autoimmunity. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.  .

Chemical structure --- General biochemistry --- Staphylococcus --- moleculaire structuur --- stamcellen --- biochemie --- eiwitten --- moleculaire biologie

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The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. The volumes will appear online before they are published in a printed book. Articles are selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments. The chapters in volume 18 are authored by experts in the field. They deal with aspects of structure and/or biological activity of selected proteins. The chapters review current research of the following topics: the Mechanism of channel gating and regulation of the activity of calcium-activated chloride channel ANO1, Structure and function of the two-component cytotoxins of Staphylococcus aureus, Membrane Fusion and Infection involving the influenza virus hemagglutinin, The impact of arrhythmogenic mutations through the structural determination of the L-type voltage-gated calcium channel, Discussion of some open questions pertaining to histone post-translational modifications and nucleosome organization in transcriptional regulation, Regulation of the extracellular SERPINA5 (protein C inhibitor) penetration through cellular membranes, Coding of Class I and II aminoacyl-tRNA synthetases, Nephrin phosphorylation in diabetes and chronic kidney injury, The structure-forming juncture in oxidative protein folding and the events in the ER, The polyspecificity of anti-lipid antibodies and its relevance to the development of autoimmunity. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.

Chemical structure --- General biochemistry --- Staphylococcus --- moleculaire structuur --- biochemie --- eiwitten --- moleculaire biologie

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This Brief presents a chemical perspective on frozen vegetables, also known as “ready-to-use” foods. It elucidates the chemical properties and modifications of vegetables from harvest and treatment to the end of their long shelf-life. Particular attention is given to the microbiological colonization of vegetables during the freezing treatments and to the chemical and physical modifications associated. The authors explore the undesired effects of this colonization through the lens of the antibiotic-resistant Staphylococci found in hermetically-package frozen vegetables. With this informative and instructive Brief, readers will understand the importance of the frozen storage technologies. .

Chemistry. --- Food --- Nutrition. --- Microbiology. --- Food Science. --- Food Microbiology. --- Biotechnology. --- Staphylococcus. --- Frozen vegetables. --- Vegetables, Frozen --- Micrococcaceae --- Frozen foods --- Food science. --- Microbiology. --- Alimentation --- Nutrition --- Health --- Physiology --- Diet --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Foods --- Dinners and dining --- Home economics --- Table --- Cooking --- Dietaries --- Gastronomy --- Science --- Health aspects --- Sanitary microbiology --- Bacteriology --- Food—Biotechnology. --- Nutrition   . --- Microbial biology --- Biology --- Microorganisms