Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis.  This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases.  The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

Neuropathology --- neurologie --- COPD (chronic obstructive pulmonary disease) --- Alzheimer-ziekte --- enzymen

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book considers chronic obstructive pulmonary disease (COPD) not as a simple inflammation of the lung but as a systemic inflammatory disease. Beginning with epidemiological studies, etiology, diagnosis and treatment, it elaborates further, illustrating some comorbidities and associations with other respiratory diseases. As such it provides numerous improved and more comprehensive treatment methods, including drug therapies as well as some non-drug therapies. There are also chapters describing the pathogenesis, genetic abnormalities and newly discovered pathogenetic mechanisms that are expected to be studied further in the future. Edited and written by pioneering researchers, each chapter summarizes the latest trends, describes future prospects and explores the unresolved and critical questions. Chronic Obstructive Pulmonary Disease - A Systemic Inflammatory Disease is a valuable resource to beginning researchers, physicians engaged in clinical practice, supervisors, and basic researchers whose work includes COPD.

Physiology of the respiratory system --- Pathology of the respiratory system --- COPD (chronic obstructive pulmonary disease) --- toxicologie --- pneumologie

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the advances in our understanding of the pathogenesis and treatment of these diseases, including the substantial advances in the topical delivery of inhaled medicines. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of respiratory medicine.

Physiology of the respiratory system --- Toxicology --- Pharmacology. Therapy --- Pathology of the respiratory system --- Pathological dermatology --- COPD (chronic obstructive pulmonary disease) --- farmacologie --- multimedia --- dermatologie --- toxicologie --- pneumologie --- astma

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book considers chronic obstructive pulmonary disease (COPD) not as a simple inflammation of the lung but as a systemic inflammatory disease. Beginning with epidemiological studies, etiology, diagnosis and treatment, it elaborates further, illustrating some comorbidities and associations with other respiratory diseases. As such it provides numerous improved and more comprehensive treatment methods, including drug therapies as well as some non-drug therapies. There are also chapters describing the pathogenesis, genetic abnormalities and newly discovered pathogenetic mechanisms that are expected to be studied further in the future. Edited and written by pioneering researchers, each chapter summarizes the latest trends, describes future prospects and explores the unresolved and critical questions. Chronic Obstructive Pulmonary Disease - A Systemic Inflammatory Disease is a valuable resource to beginning researchers, physicians engaged in clinical practice, supervisors, and basic researchers whose work includes COPD.

Pneumology/Respiratory System. --- Diseases, Obstructive. --- Chronic obstructive pulmonary disease --- COPD (Disease) --- Lung diseases, Obstructive --- Obstructive lung diseases --- Medicine. --- Respiratory organs --- Medicine & Public Health. --- Diseases. --- Lungs --- Diseases --- Obstructions --- Pneumology. --- Respiratory organs—Diseases.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book explains how analysis of the heterogeneity of chronic obstructive pulmonary disease (COPD) enhances understanding of the condition and leads to improved, personalized treatment. State of the art knowledge is presented on a range of issues related to the heterogeneity of COPD, such as phenotypes (clinical, physiologic, radiologic, etc.), genotypes, and the tools to be used for dissecting heterogeneity (CT, MRI, biomarkers, etc.). Especially modern radiologic imaging holds promise in this context, and its role is described in detail with the aid of numerous illustrations. The implications of the heterogeneity for personalized treatment are clearly identified, with description of an appropriate tailored treatment strategy for each subgroup of patients. Information is provided on both current and emerging strategies, including bronchoscopic lung volume reduction and approaches to the management of pulmonary hypertension and comorbidities. This book will be a great asset in clinical practice and research for all who have an interest in COPD, a leading cause of morbidity and mortality worldwide.

Medicine. --- Radiology. --- Respiratory organs --- Pathology. --- Medicine & Public Health. --- Pneumology/Respiratory System. --- Diagnostic Radiology. --- Disease (Pathology) --- Respiratory diseases --- Radiological physics --- Clinical sciences --- Medical profession --- Diseases. --- Lungs --- Diseases, Obstructive. --- Chronic obstructive pulmonary disease --- COPD (Disease) --- Lung diseases, Obstructive --- Obstructive lung diseases --- Diseases --- Obstructions --- Pneumology. --- Radiology, Medical. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Medical sciences --- Medicine --- Medicine, Preventive --- Respiratory organs—Diseases. --- Physics --- Radiation