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This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.

Science --- Zoology --- Immunology. Immunopathology --- Medical microbiology, virology, parasitology --- Human medicine --- immunologie --- vaccins --- HIV infecties --- medische virologie --- geneeskunde --- virologie --- vaccinatie --- proefdieren

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This book provides an in-depth explanation of the advantages and current limitations of recombinant plant-made vaccines for use in veterinary medicine, including for livestock, pets, and wild animals. Written by top scientists in the field, it discusses the background to and latest scientific advances in plant-made vaccines for the most commonly targeted veterinary infections. With the recent high-profile research into recombinant plant-made therapeutics for Ebola and Zika viruses, it is likely that the products will be commercialized and widely used in the future. Plant-made therapeutics have a variety of advantages over those made in traditional systems; however, their most fruitful application may be in veterinary medicine, due to less stringent regulations and a greater need for low-cost products.

Human biochemistry --- Immunology. Immunopathology --- Medical microbiology, virology, parasitology --- Veterinary medicine --- Agriculture. Animal husbandry. Hunting. Fishery --- Biotechnology --- vaccins --- diergeneeskunde --- medische biochemie --- biomedische wetenschappen --- landbouw --- biotechnologie --- vaccinatie

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Quatrième de couverture : "Nous vivons actuellement un profond bouleversement des stratégies thérapeutiques en cancérologie, comme en témoigne le prix Nobel de médecine 2018 attribué à James P. Allison et Tasuku Honjo pour leurs travaux sur le traitement du cancer par "inhibition de la régulation immunitaire négative". Les découvertes récentes en immunologie et la preuve de leur pertinence clinique conduisent à repenser la maladie cancéreuse, jusqu'à sa définition même. Le présent peut être vu en cancérologie comme un moment charnière entre une période où la cancérologie s'est centrée sur la tumeur et une période qui s'ouvre, recentrée sur l'hôte. L'objectif de cet ouvrage est de faire le point sur les différents acteurs de la réponse immunitaire, de revenir aux "fondamentaux", afin de comprendre les mécanismes engagés par les différentes immunothérapies, pourquoi ces thérapies sont efficaces, mais aussi potentiellement toxiques. Cet ouvrage a pour ambition d'éclairer la relation hôte-tumeur et le fonctionnement du système immunitaire face au cancer, mais également de donner les clefs pour comprendre les nouvelles approches (CAR-T, enzymes immunosuppressives, etc.) qui sont en cours de développement thérapeutique et, pour certaines d'entre elles, déjà au stade des essais cliniques. Rédigé par des équipes de référence impliquées dans la recherche fondamentale et appliquée en immunologie des tumeurs, ce livre correspond à une actualité et à un besoin. Il intéressera particulièrement chercheurs et personnels soignants en oncologie et immunologie."

Neoplastic Stem Cells --- Antibodies, Neoplasm --- Immunotherapy --- Neoplasms --- Cancer Vaccines --- Biomarkers, Tumor --- Cancer --- Vaccins anticancéreux --- Marqueurs tumoraux --- therapy --- Immunothérapie --- Thérapeutique --- Cellules cancéreuses. --- Cellules souches. --- Immunothérapie. --- Biologie. --- Immunothérapie. --- Anticorps antitumoraux. --- Cancer cells --- Immune response --- Carcinogenesis --- Cellules cancéreuses. --- Immunological aspects. --- immunology --- Vaccins anticancéreux. --- Marqueurs tumoraux. --- Thérapeutique. --- Antibodies, Neoplasm. --- Immunothérapie anticancéreuse. --- Biomarkers, Tumor. --- therapy.

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This book gathers selected peer-reviewed papers presented at the Second International Conference on Infectious Diseases and Nanomedicine (ICIDN), held in Kathmandu, Nepal on December 15–18, 2015. It also includes invited papers from the leading experts in the related fields. The book highlights the importance of “Interdisciplinary Collaborative Research for Innovation in the Biomedical Sciences,” the motto of the ICIDN conference. In particular, it addresses interdisciplinary scientific approaches for systematic understanding of the biology of major human infectious diseases and their treatment regimes by applying the tools and techniques of nanotechnology. It also provides cutting-edge information on infectious diseases and nanomedicine, focusing on various aspects of emerging infectious diseases: cellular and molecular microbiology; epidemiology and infectious disease surveillance; antimicrobials, vaccines and alternatives; drug design, drug delivery and tissue engineering; nanomaterials and biomedical materials.

Chemical structure --- Chemistry --- General biochemistry --- Immunology. Immunopathology --- Medical microbiology, virology, parasitology --- Clinical chemistry --- Infectious diseases. Communicable diseases --- vaccins --- moleculen --- klinische chemie --- medische chemie --- nanotechniek --- biochemie --- chemie --- besmettelijke ziekten --- vaccinatie --- atomen --- moleculaire biologie

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The dangerous decline in vaccinations in many developed countries is at the heart of a lively debate that confirms how important the subject is today. Vaccinations are among mankind’s most important scientific discoveries, yet they continue to be viewed with suspicion by part of the public – the victims of disinformation campaigns, instrumentalization and unfounded fears. There is, however, also an evolutionary explanation for these irrational beliefs, and countering the growing social opposition will be extremely difficult without grasping it. This book, which sheds new light on the safety and importance of vaccinations, is intended both for parents and those readers who want to understand the role of vaccinations in contemporary society, where the ease of access to knowledge is both a great opportunity and a great responsibility. The chapters follow a historical progression and conclude with a discussion of the most recent cognitive theories on how to overcome this opposition to vaccinations.

Science --- Didactics of medicine --- History of human medicine --- Immunology. Immunopathology --- Hygiene. Public health. Protection --- Medical microbiology, virology, parasitology --- Human medicine --- HO (hoger onderwijs) --- immunologie --- vaccins --- preventieve gezondheidszorg --- popularisering wetenschap --- geneeskunde --- geschiedenis --- gezondheidspromotie --- vaccinatie