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The propagation of hepatitis C from acute to chronic infection and afterward to end-stage liver diseases (hepatic fibrosis, cirrhosis, and hepatocellular carcinoma) involves a highly orchestrated series of molecular and cellular events, including a plethora of genes and cell signaling cascades. The treatment paradigms was revolutionized after the development and approval of all oral interferon-free direct-acting antivirals achieving higher sustained virologic response rates in treated individuals. This book pragmatically overviews the intricate interplay between viral and host factors during hepatitis C virus infection progression, as well as other hepatitis C-associated clinical implications. Hepatitis C - From Infection to Cure also provides up-to-date information about hepatitis C cures for clinicians, physicians, and healthcare providers with an ample understanding of the current treatment horizon, as well as other investigational and emerging treatment strategies. The authors with their valuable scientific contributions belong to many eminent institutes around the world and are much experienced in hepatitis C virology, pathology, and therapeutics.

MEDICAL / Hepatology. --- Medicine --- Hepatology --- Gastroenterology --- Health Sciences

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The main objective of this volume is to diffuse the latest information related to hearing loss, which is among the most prevalent chronic disabilities worldwide. Nowadays, it is clear that the identification and rehabilitation of hearing impairment, when possible, have to be adequately and promptly managed because hearing loss can seriously interfere with psychosocial development, family dynamics, and social interactions. This book has been edited with a strong educational perspective (all chapters include an extensive introduction to their corresponding topic and an extensive glossary of terms). This book contains various materials suitable for graduate students in audiology, ENT, hearing science, and neurosciences.

Ear --- Hearing disorders --- Diseases. --- Diagnosis. --- Otology --- Medicine --- Otorhinolaryngology --- Health Sciences

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This book focuses on metagenomics for gut microbiomes. The host is deprived of various benefits derived from the numerous gut microbes for food metabolism and health. However, polysaccharides such as cellulose, xylans, resistant starch, and inulin that are found in vegetables in our diet are digested by certain species that colonize the intestines. In contrast, metagenomic studies that reiterate microbiome intrinsic factors from particular communities and lifestyles and are extremely important for bacterial communities traveling over a long distance have entered a new era. Predominantly to understand the behavior of organisms and their action in a host, next-generation sequencing will provide a new insight into analyzing the livestock industry, agriculture, and human health risks and will consider for future development novel therapies for various diseases through identification of advanced tools. Hence, the book will give more precise information on the role of gut microbiomes in the host.

Gastrointestinal system --- Microbiology. --- Prebiotics --- Probiotics --- Medicine --- Gastroenterology --- Health Sciences

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The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Endothelium --- Diseases. --- Epithelium --- Medicine --- Cardiology and Cardiovascular Medicine --- Health Sciences

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I am very proud and excited to introduce to you this book, which provides many interesting indications on how to better understand and handle the world of optical coherence tomography (OCT). Reading the chapters, you will be aware that this device is extremely important not just in the clinical practice of retinal diseases, but is also very useful as a surgical tool. Moreover, application of OCT has crossed the borders of the retina and is currently being applied to corneal diseases and glaucoma. I am confident you will find enough useful information to improve your practice using OCT and to provide a better quality of care for your patients.

Ophthalmology. --- Medicine --- Eye --- Diseases --- Ophthalmic Pathology --- Ophthalmology --- Health Sciences