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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

thermodynamic modeling --- molecular dynamics simulation --- poorly soluble drugs --- amorphous solid dispersions --- dissolution enhancement --- crystallization tendency --- continuous processing --- stability --- milling --- granulation --- thermal analysis --- amorphous --- ball milling --- pharmaceutical glass --- dissolution --- rebamipide --- poloxamer --- classification --- polyelectrolytes --- amorphisation --- self-assembly --- dissolution rate --- miscibility --- bioavailability --- solubility --- evaporation --- mesoporous --- polyelectrolyte excipient matrix --- polymer --- bicaludamide --- phase diagram --- Weibull dissolution model --- spectroscopic techniques --- anticancer drugs --- manufacturing methods --- nucleation --- molecular complex --- nanoaggregates --- enrofloxacin --- accelerated stability test --- solubility enhancement --- amorphous solid dispersion --- tadalafil --- process development --- amorphous polymeric salt --- Wood’s apparatus --- hot melt extrusion --- solid dispersions --- intrinsic dissolution rate --- solid dispersion --- interaction --- crystallization --- spray drying --- characterization --- ciprofloxacin