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Chemical structure --- Organic chemistry --- General biochemistry --- moleculaire structuur --- organische chemie --- protein-engineering --- biochemie --- eiwitten --- moleculaire biologie

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This snapshot volume is designed to provide a smooth entry into the field of protein folding. Presented in a concise manner, each section introduces key concepts while providing a brief overview of the relevant literature. Outlook subsections will pinpoint specific aspects related to emerging methodologies, concepts and trends.

Chemical structure --- Organic chemistry --- General biochemistry --- moleculaire structuur --- organische chemie --- protein-engineering --- biochemie --- eiwitten --- moleculaire biologie

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Chemical structure --- General biochemistry --- Hydrobiology --- Hunting. Fishery. Aquaculture --- moleculaire structuur --- aquacultuur --- hydrobiologie --- protein-engineering --- biochemie --- water --- eiwitten --- klonen --- wetenschappen --- moleculaire biologie

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In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.

Chemical structure --- Genetics --- Biomembranes --- Histology. Cytology --- General biochemistry --- Molecular biology --- Human medicine --- celmembranen --- membranen (biologie) --- protein-engineering --- proteomics --- biochemie --- biologie --- geneeskunde --- eiwitten --- moleculaire biologie --- proteïnen --- steroïden

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This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

Chemical structure --- Genetics --- General biochemistry --- Molecular biology --- Human genetics --- Neuropathology --- Human medicine --- genen --- neurologie --- medische genetica --- protein-engineering --- stamcellen --- biochemie --- geneeskunde --- eiwitten --- moleculaire biologie --- enzymen