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Our understanding of the ‘tree of life’, with powerful implications for human genetics, human health and our own human nature, has recently completely changed. This book is about a new method of telling the story of life on earth – through molecular phylogenetics. It involves a fairly simple method – the reading of the deep history of life by looking at the variation in protein molecules found in living organisms. For instance, we now know that roughly eight per cent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection. In The Tangled Tree, acclaimed science writer David Quammen chronicles these discoveries through the lives of the researchers who made them – such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about ‘mosaic’ creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health. Quammen explains how molecular studies of evolution have brought startling recognitions about the tangled tree of life – including where we humans fit into it. Thanks to new technologies, we now have the ability to alter even our genetic composition – through sideways insertions, as nature has long been doing. The Tangled Tree is a brilliant exploration of our transformed understanding of evolution and of life’s history itself.
Evolutionary genetics --- Genetic transformation --- Evolution (Biology)
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The book focuses on the evolutionary impact of horizontal gene transfer processes on pathogenicity, environmental adaptation and biological speciation. Newly acquired genetic material has been considered as a driving force in evolution for prokaryotic genomes for many years, with recent technical developments advancing this field further. However, the extent and implications of gene transfer between prokaryotes and eukaryotes still raise controversies. This multi-authored volume introduces various means by which DNA can be exchanged, covers gene transfer between prokaryotes and their viruses as well as between bacteria and eukaryotes, such as fungi, plants and animals, and addresses the role of horizontal gene transfer in human diseases. Aspects discussed also include the relevance for virulence and drug resistance development on one hand, and for the occurrence of naturally derived antibiotics and other secondary metabolites on the other hand. This book offers new insights to anyone interested in genome evolution and the exchange of DNA between the different domains of life, the genetic toolkit for adaptation and the emergence of multidrug resistant bacteria. .
Genetic transformation. --- Genetics. --- Drug interactions. --- Evolution (Biology). --- Microbial ecology. --- Medical genetics. --- Genetic engineering. --- Genetics and Genomics. --- Drug Resistance. --- Evolutionary Biology. --- Microbial Ecology. --- Gene Function. --- Genetic Engineering. --- Interactions, Drug --- Drugs --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Environmental microbiology --- Microorganisms --- Ecology --- Microbiology --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Side effects --- Genetic aspects --- Drug resistance. --- Evolutionary biology. --- Resistance to drugs --- Pharmacology
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