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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Nanoparticles --- nanomaterials --- Drug delivery --- Toxicology and safety --- environmental control --- material --- imaging --- antibiotics --- Cancer --- magnetic nanoparticles

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[This book focus on the most recent advances related to the design and processing methods of different nanobiomaterials, films, and fibers; surface functionalization strategies, including biological performance assessment and cytocompatibility; and their applications in tissue engineering strategies.]

antibacterial activity --- tissue engineering --- biomaterials fabrication --- regeneration --- Gadolinium chelate --- MRI --- cell sheet --- drug delivery --- magnetic nanoparticles --- graphene --- silk fibroin --- titania nanotubes --- biointegration --- anodic oxidation --- protein --- nanotechnology --- bone regeneration --- osteoclastogenesis --- dental stem cells --- mimetic peptide --- epithelial-mesenchymal interactions --- cornea endothelial cells --- wound healing --- antibacterial properties --- nanomaterials --- medicine --- RANK-RANKL-OPG --- nanofibers --- odontogenic cells --- lysophosphatidic acid --- photocatalytic activity --- dental enamel regeneration --- dental implant

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The use of biocatalysts, including enzymes and metabolically engineered cells, has attracted a great deal of attention in the chemical and bio-industry, because biocatalytic reactions can be conducted under environmentally-benign conditions and in more sustainable ways. The catalytic efficiency and chemo-, regio-, and stereo-selectivity of enzymes can be enhanced and modulated using protein engineering. Metabolic engineering seeks to enhance cellular biosynthetic productivity of target metabolites via controlling and redesigning metabolic pathways using multi-omics analysis, genome-scale modeling, metabolic flux control, and reconstruction of novel pathways. The aim of this book is to cover the recent advances in biocatalysis and metabolic engineering for biomanufacturing of biofuels, chemicals, biomaterials, and pharmaceuticals. Reviews and original research articles on the development of new strategies to improve the catalytic efficiency of enzymes, biosynthetic capability of cell factories, and their applications in production of various bioproducts and chemicals are included.

n/a --- fluorescein diacetate --- Methylosinus sporium strain 5 --- soluble methane monooxygenase --- tunable expression system --- FTIR spectroscopy --- mevalonate kinase 1 --- poly(ethylene glycol) --- tetraethylene glycol --- review --- mevalonate (MVA) --- biofilm --- 5-hydroxymethylfurfural --- polymer functionalization --- microbial production --- microbial cell factory --- bio-hydrogen --- redox enzymes --- specific recognition --- fed-batch fermentation --- monoterpene --- Vitreoscilla --- Pvgb --- bioreactor --- 3-hydroxypropionic acid --- cascade reactions --- synthetic biology --- aerobic methane bioconversion --- starch hydrolysis --- CYP153A --- MEP pathway --- cross-linked enzyme aggregate --- interfacial activation --- expression vectors --- Combi-CLEAs --- polyethyleneimine --- bovine serum albumin --- polyurethane foam --- 12-hydroxydodecanoic acid --- MEV pathway --- amyloglucosidase --- total enzymatic activity --- Nylon 12 --- biocatalytic reaction --- Myceliophthora --- whole-cell biotransformation --- magnetic nanoparticles --- lipase immobilization --- Methanosarcina mazei --- biocatalysis --- acetate --- vgb --- C–H activation --- artificial self-sufficient P450 --- whole cell --- bioplastics --- Corynebacterium glutamicum --- chemicals addition --- enzyme modulation --- Eversa --- enzyme stabilization --- biocatalysts --- prokaryotic microbial factory --- synthetic metabolic pathways --- mannose --- immobilization --- (?)-?-bisabolol --- hydrogenase --- O2 activation --- string film reactor --- fatty acid synthesis --- ?-aminododecanoic acid --- transesterification --- mass transfer performance --- dodecanoic acid --- metabolic engineering --- glyoxal oxidase --- small molecules --- Candida antarctica Lipase B --- C-H activation