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Book
Systems and synthetic immunology
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ISBN: 9811533504 9811533490 Year: 2020 Publisher: Singapore : Springer Singapore : Imprint: Springer,

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Abstract

Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology. The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.

Keywords

Immunology. --- Systems biology. --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Immunobiology --- Life sciences --- Serology --- Biomedical engineering. --- Cytokines. --- Growth factors. --- Genetic engineering. --- Systems Biology. --- Biomedical Engineering/Biotechnology. --- Cytokines and Growth Factors. --- Genetic Engineering. --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides --- Cellular immunity --- Immune response --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Regulation --- Sistema immunitari --- Biologia --- Enginyeria genètica --- Intervenció genètica --- Manipulació genètica --- Recombinació genètica --- ADN recombinant --- Clonatge --- Clonatge molecular --- Enginyeria de proteïnes --- Enginyeria genètica animal --- Enginyeria genètica vegetal --- Teràpia genètica --- Fecundació in vitro --- Organismes transgènics --- Ciències biològiques --- Ciències de la vida --- Adaptació (Biologia) --- Anatomia --- Biodiversitat --- Bioelectrònica --- Bioenginyeria --- Bioespeleologia --- Biofísica --- Biogeografia --- Biolingüística --- Biologia aquàtica --- Biologia computacional --- Biologia de la conservació --- Biologia de poblacions --- Biologia del desenvolupament --- Biologia econòmica --- Biologia espacial --- Biologia experimental --- Biologia humana --- Biomatemàtica --- Biometria --- Bioquímica --- Biotecnologia --- Cèl·lules --- Citologia --- Criobiologia --- Cronobiologia --- Ecologia --- Embriologia --- Evolució (Biologia) --- Exobiologia --- Fecundació --- Filogènia --- Fisiologia --- Fotobiologia --- Generació espontània --- Genètica --- Geobiologia --- Immunologia --- Metabolisme --- Microbiologia --- Mimetisme (Biologia) --- Morfogènesi --- Mort (Biologia) --- Neurobiologia --- Ontogènesi --- Parasitologia --- Partenogènesi --- Protoplasma --- Psicobiologia --- Radiobiologia --- Regeneració (Biologia) --- Reproducció --- Sexualitat (Biologia) --- Simbiosi --- Variació (Biologia) --- Vitalisme --- Biomassa --- Ciències naturals --- Evolució --- Història de la biologia --- Il·lustració biològica --- Vida (Biologia) --- Sistema immunològic --- Cèl·lules immunocompetents --- Medul·la òssia --- Sistema limfàtic


Book
Combined Discrete and Continual Approaches in Biological Modelling
Authors: ---
ISBN: 3030415287 3030415279 Year: 2020 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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Abstract

Basic laws of nature are rather simple, but observed biological structures and their dynamic behaviors are unbelievably complicated. This book is devoted to a study of this “strange” relationship by applying mathematical modeling to various structures and phenomena in biology, such as surface patterns, bioadhesion, locomotion, predator-prey behavior, seed dispersal, etc. and revealing a kind of self-organization in these phenomena. In spite of diversity of biological systems considered, two main questions are (1) what does self-organization in biology mean mathematically and (2) how one can apply this knowledge to generate new knowledge about behavior of particular biological system? We believe that this kind of “biomimetics” in computer will lead to better understanding of biological phenomena and possibly towards development of technical implications based on our modeling.

Keywords

Biological models. --- Models, Biological --- Bioinformatics . --- Computational biology . --- Surfaces (Physics). --- Interfaces (Physical sciences). --- Thin films. --- System theory. --- Zoology. --- Plant science. --- Botany. --- Biology—Technique. --- Computer Appl. in Life Sciences. --- Surface and Interface Science, Thin Films. --- Complex Systems. --- Plant Sciences. --- Biological Techniques. --- Botanical science --- Phytobiology --- Phytography --- Phytology --- Plant biology --- Plant science --- Biology --- Natural history --- Plants --- Animals --- Systems, Theory of --- Systems science --- Science --- Films, Thin --- Solid film --- Solid state electronics --- Solids --- Surfaces (Technology) --- Coatings --- Thick films --- Surface chemistry --- Surfaces (Physics) --- Physics --- Bioinformatics --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Philosophy --- Data processing --- Floristic botany --- Models matemàtics --- Biologia --- Bioinformàtica --- Informàtica biològica --- Ciències de la informació --- Biologia computacional --- Ciències biològiques --- Ciències de la vida --- Adaptació (Biologia) --- Anatomia --- Biodiversitat --- Bioelectrònica --- Bioenginyeria --- Bioespeleologia --- Biofísica --- Biogeografia --- Biolingüística --- Biologia aquàtica --- Biologia de la conservació --- Biologia de poblacions --- Biologia del desenvolupament --- Biologia econòmica --- Biologia espacial --- Biologia experimental --- Biologia humana --- Biomatemàtica --- Biometria --- Bioquímica --- Biotecnologia --- Cèl·lules --- Citologia --- Criobiologia --- Cronobiologia --- Ecologia --- Embriologia --- Evolució (Biologia) --- Exobiologia --- Fecundació --- Filogènia --- Fisiologia --- Fotobiologia --- Generació espontània --- Genètica --- Geobiologia --- Immunologia --- Metabolisme --- Microbiologia --- Mimetisme (Biologia) --- Morfogènesi --- Mort (Biologia) --- Neurobiologia --- Ontogènesi --- Parasitologia --- Partenogènesi --- Protoplasma --- Psicobiologia --- Radiobiologia --- Regeneració (Biologia) --- Reproducció --- Sexualitat (Biologia) --- Simbiosi --- Variació (Biologia) --- Vitalisme --- Biomassa --- Ciències naturals --- Evolució --- Història de la biologia --- Il·lustració biològica --- Vida (Biologia) --- Models (Matemàtica) --- Models experimentals --- Models teòrics --- Mètodes de simulació --- Anàlisi de sistemes --- Mètode de Montecarlo --- Modelització multiescala --- Models economètrics --- Models lineals (Estadística) --- Models multinivell (Estadística) --- Models no lineals (Estadística) --- Programació (Ordinadors) --- Simulació per ordinador --- Teoria de màquines --- Models biològics


Book
Practical Immunocytochemistry in Diagnostic Cytology
Authors: ---
ISBN: 3030466566 3030466558 Year: 2020 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This book provides current information for a judicious use of conventional and molecular ICC markers performed in cytologic samples to help in the cost-effective diagnosis of superficial and deep-seated masses. By providing both an eminently practical information for appropriate technical preparation of cytologic samples and a systematic exposure of the immunophenotypic and biomolecular characteristics of normal and pathological cells, the reported morphological-molecular findings highlight the characteristics of different lesions that are useful for the practical solution of a particular differential diagnosis. Chapters include description of the cytomorphology followed by a practical ICC staining pattern for each entity. Cytologic materials include serous effusions, exfoliative cytology, fine needle aspiration cytology of superficial and deep-seated masses, and squash preparation from central nervous system masses. Practical Immunocytochemistry in Diagnostic Cytology serves as a valuable resource towards understanding critical differences between tests performed on tissue samples and those carried out on cytologic samples.


Book
Retinal Development : Methods and Protocols
Author:
ISBN: 1071601741 107160175X Year: 2020 Publisher: New York, NY : Springer US : Imprint: Humana,

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This volume details commonly used molecular and cellular techniques and specialized methodologies for studying retina neuronal subtypes and electrophysiology. Chapters describe techniques for anatomical studies of retinal ganglion cell morphology, gap-junction-mediated neuronal connection, multi-electrode array recording on mouse retinas, and paired recording to study the electrical coupling between photoreceptors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Retinal Development: Methods and Protocols aims to provide readers with a set of practical experimental tools to study retinal development, regeneration, and function of mature retinal neurons. Many of the protocols and strategies described in one organism can be easily adapted to applications in different model systems.


Book
Biophysics of Membrane Proteins : Methods and Protocols
Authors: ---
ISBN: 1071607243 1071607235 Year: 2020 Publisher: New York, NY : Springer US : Imprint: Humana,

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This volume provides recent advances in the field of biophysics of membrane proteins. Chapters are divided into several parts: detailing biochemistry and functional analysis, experimental and theoretical structural determinations, membrane protein dynamics, and conformation studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biophysics of Membrane Proteins: Methods and Protocols aims to provide comprehensive protocols with notes to help further the understanding of key membrane protein structure and function for students, academics, and industrial researchers.


Book
Antifreeze Proteins Volume 2 : Biochemistry, Molecular Biology and Applications
Authors: ---
ISBN: 3030419487 3030419479 Year: 2020 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This second volume, written in four parts, offers the reader a thorough review on molecular, structural and applied aspects of antifreeze proteins. The first part treats the structure-function relationship and the physicochemical properties of antifreeze proteins; the second part provides insight into molecular mechanisms affected by antifreeze proteins; the third part presents some of the potential applications in various professional sectors and in the last part the book content is summarized and future research directions and ideas are discussed. Together with the first volume on the environment, systematic and evolution of antifreeze proteins, this book represents a unique, comprehensive work and a must-have for students and scientists in biochemistry, molecular biology, biotechnology and physical chemistry.


Book
My Thoughts on Biological Evolution
Author:
ISBN: 9811561656 9811561648 Year: 2020 Publisher: Singapore : Springer Singapore : Imprint: Springer,

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This book, written by Motoo Kimura (1924–94), is a classic in evolutionary biology. In 1968, Kimura proposed the “neutral theory of molecular evolution”, which became the theoretical basis of modern evolutionary studies. After publishing his work in 1983 in the book “Neutral Theory of Molecular Evolution”, Kimura wrote this book in 1988 for the general public. It was originally written in Japanese and is translated here for the first time. In the book, Kimura first summarizes the development of evolutionary theory since Lamarck and Darwin. He then shows how the search for mechanisms of evolution developed into population genetics and describes how the study of molecular evolution matured by taking in the fruits of molecular biology. Kimura proceeds to carefully explain his neutral evolution theory at the molecular level. Finally, he presents his view of the world from an evolutionary perspective. The book has long served as an in-depth introduction to evolutionary biology for students and young researchers in Japan. There has been remarkably rapid progress in the field of bioscience at the molecular level over the past 30 years. Nevertheless, the book remains an important contribution that laid the foundations for what followed in molecular evolutionary studies.


Book
Cell Biology and Translational Medicine, Volume 9 : Stem Cell-Based Therapeutic Approaches in Disease
Author:
ISBN: 3030549178 303054916X Year: 2020 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the ninth volume of a continuing series.


Book
Macrophage Migration Inhibitory Factor : Methods and Protocols
Authors: ---
ISBN: 1493999354 1493999362 Year: 2020 Publisher: New York, NY : Springer US : Imprint: Humana,

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This volume looks at--and discusses the techniques of--a range of areas in biology in which macrophage migration inhibitory factor (MIF) is studied. Topics covered in this book include methods to quantify MIF in cell supernatants and human samples, using ELISA and western blot; detection and analysis of intracellular MIF using flow cytometry; genotyping of human MIF polymorphisms, detection of MIF expression in a marine invertebrate using rapid amplification of cDNA RACE; studying the MIF receptor CD74 in tissues using immunohistochemistry; and studying MIF in models of disease such as asthma, Plasmodium infection, and gout. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Macrophage Migration Inhibitory Factor: Methods and Protocols is a valuable resource that will help researchers gain a new understanding of MIF biology in health and disease. .


Book
Antifreeze Proteins Volume 1 : Environment, Systematics and Evolution
Authors: ---
ISBN: 3030419290 3030419282 Year: 2020 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This first volume provides a comprehensive overview on evolutionary, environmental and systematic aspects of antifreeze proteins. It shortly explains the physical properties of ice and further intelligibly describes the biology of the antifreeze proteins in different organisms. It offers a detailed insight into their history of evolution. In addition the book discusses the status of the current knowledge and ongoing research and highlights also those parts, where further investigation needs to be done. Together with the second volume on the biochemistry and molecular biology of antifreeze proteins, this book represents a unique, comprehensive work and a must-have for students and scientists in biochemistry, evolution, physiology and physical chemistry.

Keywords

Antifreeze proteins. --- Proteins --- Proteins . --- Evolutionary biology. --- Biophysics. --- Biological physics. --- Protein Science. --- Evolutionary Biology. --- Biological and Medical Physics, Biophysics. --- Biological physics --- Biology --- Medical sciences --- Physics --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Proteïnes --- Biofísica --- Termoregulació --- Equilibri tèrmic (Biologia) --- Regulació de la temperatura corporal --- Regulació del calor animal --- Regulació tèrmica (Biologia) --- Temperatura corporal --- Sistemes de control biològic --- Biologia física --- Física biològica --- Biologia --- Física --- Absorció (Fisiologia) --- Biologia molecular --- Biònica --- Biomagnetisme --- Biomecànica --- Enginyeria biomèdica --- Física mèdica --- Interfícies biològiques --- Reologia (Biologia) --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica

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