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Radioisotopes. --- Stable isotopes. --- Earth sciences. --- Geosciences --- Environmental sciences --- Physical sciences --- Isotopes --- Radioactive isotopes --- Radioactive nuclides --- Radionuclides --- Nuclear engineering --- Radioactive substances --- Radiochemistry

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This is Volume II in a three-volume set on the Behavior of Radionuclides in the Environment, focusing on Chernobyl. Now, so many years after the Chernobyl accident, new data is emerging and important new findings are being made. The book reviews major research achievements concerning the behavior of Chernobyl-derived radionuclides, including their air transport and resuspension, mobility and bioavailability in the soil-water environment, vertical and lateral migration in soils and sediments, soil-to-plant and soil-to-animal transfer, and water-to-aqueous biota transfer. The long-term dynamics of radionuclides in aquatic ecosystems are also discussed, in particular, the heavily contaminated cooling pond of the Chernobyl Nuclear Power Plant, which is in the process of being decommissioned. Lessons learned from long-term research on the environmental behavior of radionuclides can help us understand the pathways of environmental contamination, which, in turn, will allow us to improve methods for modeling and predicting the long-term effects of pollution. This book features a wealth of original data and findings, many of which have never been published before, or were not available internationally. The contributing authors are experts from Ukraine, Russia and Belarus with more than 30 years of experience investigating Chernobyl-derived radionuclides in the environment. The content presented here can help to predict the evolution of environmental contamination following a nuclear accident, and specifically the Fukushima Dai-ichi nuclear power plant accident.

Radioisotopes --- Environmental aspects. --- Radioactive isotopes --- Radioactive nuclides --- Radionuclides --- Isotopes --- Nuclear engineering --- Radioactive substances --- Radiochemistry --- Radiation protection. --- Radiation—Safety measures. --- Water pollution. --- Environmental management. --- Nuclear chemistry. --- Effects of Radiation/Radiation Protection. --- Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution. --- Environmental Management. --- Nuclear Chemistry. --- Aquatic pollution --- Fresh water --- Fresh water pollution --- Freshwater pollution --- Inland water pollution --- Lake pollution --- Lakes --- Reservoirs --- River pollution --- Rivers --- Stream pollution --- Water contamination --- Water pollutants --- Water pollution --- Pollution --- Waste disposal in rivers, lakes, etc. --- Radiation monitoring --- Radiation protection --- Chemistry, Nuclear --- Chemistry, Physical and theoretical --- Environmental stewardship --- Stewardship, Environmental --- Environmental sciences --- Management

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Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.

Medicine --- kinetic analysis --- Siglec-9 --- gallium-68 --- vascular adhesion protein --- VAP-1 --- infection --- inflammation --- osteomyelitis --- animal model --- Staphylococcus aureus --- multiple myeloma --- positron emission tomography/computed tomography --- radiopharmaceuticals --- 18F-fluorodeoxyglucose --- tetrazine ligation --- PET --- SPECT --- indium-11 --- fluorine-18 --- positron emission tomography (PET), defluorination --- isotopic exchange --- silicon-based fluoride acceptor --- bioorthogonal chemistry --- tetrazine --- inverse electron-demand Diels-Alder ligation --- opioid --- naloxone --- overdose --- fentanyl --- carfentanil --- [11C]carfentanil --- positron emission tomography --- receptor occupancy --- pharmacokinetics --- [18F]AlF --- NOTA --- NODAGA --- PODS --- thiol-reactive --- linker --- affibody molecule --- bioconjugation --- EGFR --- tumor imaging --- vulnerable plaque --- molecular imaging --- PET imaging --- nanobody --- single-domain antibody --- sub-millimetre resolution --- AlF-radiolabelling --- preclinical radiopharmaceutical dosimetry --- image-based internal dosimetry --- OLINDA --- MCT1/MCT4 lactate transporter inhibitor --- [18F]FACH --- radiation safety --- sigma-1 receptor availability --- orthotopic xenograft of glioblastoma in mouse --- small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) --- (S)-(−)-[18F]fluspidine --- imaging-based biomarker --- SV2A protein --- PET radiotracers --- synaptic loss --- radiochemistry --- preclinical development --- clinical outcomes --- monocarboxylate transporters (MCTs) --- FACH --- 18F-labeled analog of FACH --- α-CCA --- blood-brain barrier (BBB) --- positron emission tomography (PET) imaging --- peptides --- proteolysis --- metabolic stability

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Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.

kinetic analysis --- Siglec-9 --- gallium-68 --- vascular adhesion protein --- VAP-1 --- infection --- inflammation --- osteomyelitis --- animal model --- Staphylococcus aureus --- multiple myeloma --- positron emission tomography/computed tomography --- radiopharmaceuticals --- 18F-fluorodeoxyglucose --- tetrazine ligation --- PET --- SPECT --- indium-11 --- fluorine-18 --- positron emission tomography (PET), defluorination --- isotopic exchange --- silicon-based fluoride acceptor --- bioorthogonal chemistry --- tetrazine --- inverse electron-demand Diels-Alder ligation --- opioid --- naloxone --- overdose --- fentanyl --- carfentanil --- [11C]carfentanil --- positron emission tomography --- receptor occupancy --- pharmacokinetics --- [18F]AlF --- NOTA --- NODAGA --- PODS --- thiol-reactive --- linker --- affibody molecule --- bioconjugation --- EGFR --- tumor imaging --- vulnerable plaque --- molecular imaging --- PET imaging --- nanobody --- single-domain antibody --- sub-millimetre resolution --- AlF-radiolabelling --- preclinical radiopharmaceutical dosimetry --- image-based internal dosimetry --- OLINDA --- MCT1/MCT4 lactate transporter inhibitor --- [18F]FACH --- radiation safety --- sigma-1 receptor availability --- orthotopic xenograft of glioblastoma in mouse --- small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) --- (S)-(−)-[18F]fluspidine --- imaging-based biomarker --- SV2A protein --- PET radiotracers --- synaptic loss --- radiochemistry --- preclinical development --- clinical outcomes --- monocarboxylate transporters (MCTs) --- FACH --- 18F-labeled analog of FACH --- α-CCA --- blood-brain barrier (BBB) --- positron emission tomography (PET) imaging --- peptides --- proteolysis --- metabolic stability